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http://dx.doi.org/10.6114/jkood.2014.27.3.072

Oral Administration Effects of Herbal Extracts on Atopic Dermatitis in Balb/c Mice Sensitized by Ovalbumin  

Kim, Kyung-Jin (Department of Ophthalmology, Otolaryngology and Dermatology, College of Korean Medicine, Gachon University)
Kim, Gyung-Jun (Department of Ophthalmology, Otolaryngology and Dermatology, College of Korean Medicine, Gachon University)
Publication Information
The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology / v.27, no.3, 2014 , pp. 72-83 More about this Journal
Abstract
Objective: This study was to evaluate whether herbal mixture (HM-A : Houttuynia cordata Thunberg, Rubus coreanus, Rehmannia glutinosa, Prunus yedoensis, HM-B : Houttuynia cordata Thunberg, Rubus coreanus, Rehmannia glutinosa, Angelica gigas nakai) supresses the development of atopic dermatitis in Balb/c mice sensitized by ovalbumin. Methods: Mice were sensitized by intraperitoneal injection of ovalbumin plus aluminum hydroxide hydrate, followed by epicutaneous sensitization for 6 weeks. After induced atopic dermatitis, HM-A and HM-B were orally administrated for two weeks(once a two days) as a 50 mg/kg concentration. After all mice were sacrificed at the end of the experiment, skin and blood were harvested. Results: Oral administration group was reduced the infiltration of eosinophils, mast cells and total T cells on the skin areas as well as blood analysis. Also, cutaneous expression of IL-4,13,17 decreased. Blood IgE level was decreased. Conclusion: These drugs could be potential candidates for the atopic dermatitis.
Keywords
Atopic dermatitis; Houttuynia cordata Thunberg; Rubus coreanus; Rehmannia glutinosa; Prunus yedoensis; Angelica gigas nakai; Ovalbumin; Balb/c Mice;
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Times Cited By KSCI : 9  (Citation Analysis)
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