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http://dx.doi.org/10.6114/jkood.2014.27.3.106

Protective Effects of Complex Diet of Korean red ginseng and fish oil on UV-induced Photoaging  

Mun, Yeun-Ja (BK21-plus Team, Professional Graduate School of Oriental Medicine, Wonkwang University)
Jeon, Byoung-Kook (BK21-plus Team, Professional Graduate School of Oriental Medicine, Wonkwang University)
Kim, Tae-Hyun (Department of Herbal Resources, Professional Graduate School of Oriental Medicine, Wonkwang University)
Lee, Jin-Ho (BK21-plus Team, Professional Graduate School of Oriental Medicine, Wonkwang University)
Choi, Hyung-Wook (Department of Herbal Resources, Professional Graduate School of Oriental Medicine, Wonkwang University)
Lim, Kyu-Sang (Department of Herbal Resources, Professional Graduate School of Oriental Medicine, Wonkwang University)
Woo, Won-Hong (Department of Anatomy, College of Oriental Medicine, Wonkwang University)
Publication Information
The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology / v.27, no.3, 2014 , pp. 106-114 More about this Journal
Abstract
Objective : UV irradiatiion causes skin-aging involving coarse wrinkles, thickning, dyspigmentation, and rough skin surface. This study was aimed to elucidate the anti-winkle activity of complex diet of Korean red ginseng (RG) and fish oil (FO) on UV-induced Photoaging. Methods : To investigated photo-protective effects of Korean red ginseng and fish oil on UV-induced damaged skins, SKH hairless female mice were randomly divided into six groups [control, UV, UV/RG, UV/FO, UV/RG/FO(low), UV/RG/FO(high)]and orally administered three times a week respectively. UV radiation was applied to the backs of the mice three times a week for 8 weeks. Expressions of matrix metalloproteinase (MMP)-3, MMP-13 and tissue inhibitor matrix metalloproteinase (TIMP)-1 in skin were measured by immunohistochemical staining. Results : In this study, UVB-induced epidermal hypertropy was diminished by RG group or FO group or complex group of RG and FO. Expression levels of MMP-3 and MMP-13 were reduced and expression level of TIMP-1 was increased by RG group or FO group or complex group of RG and FO. Especially MMP-3 and MMP-13 were markedly reduced by diet of FO and complex diet of RG and FO compared with untreated group. Conclusions : This results suggest that complex diet of RG and FO have a anti-wrinkle activity on UV-induced photo-aging and intrinsic aging.
Keywords
Korean red ginseng (RG); Fish oil (FO); MMP-3; MMP-13; TIMP-1;
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