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http://dx.doi.org/10.6114/jkood.2014.27.1.068

Acute Oral Toxicity Study of Dictamnus dasycarpus Turcz in SD Rats  

Seok, Ji-Hyun (Toxicological Research Division, National Institute of Food and Drug Safety Evaluation, Ministry of Food and Drug Safety)
Roh, Hang-Sik (Toxicological Research Division, National Institute of Food and Drug Safety Evaluation, Ministry of Food and Drug Safety)
Jeong, Ja-Young (Toxicological Research Division, National Institute of Food and Drug Safety Evaluation, Ministry of Food and Drug Safety)
Ha, Hun-Yong (Department of National Medicine Resources, Semyung University)
Publication Information
The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology / v.27, no.1, 2014 , pp. 68-78 More about this Journal
Abstract
Objectives : This study was carried out to evaluate the acute oral toxicity of Dictamnus dasycarpus Turcz in Sprague-Dawley(SD) rats. Methods : Male and female rats were administered orally with Dictamnus dasycarpus Turcz water extract of 1,000 mg/kg(low dosage group), 2,000 mg/kg(middle dosage group) and 4,000 mg/kg(high dosage group). We daily observed number of deaths, clinical signs and gross findings for 7 days. After 7 days, we measured body and organs weight. Also we analyzed hematological changes. Results : No dead SD rats and no clinical signs were found during the experiment period. Also other specific changes were not found between control and treated groups in hematology. But we found out subtle changes in body weight and individual organ weight of the female group. In addition specific changes were observed in serum biochemical value of female group. Conclusions : These results suggest that water soluble extract of Dictamnus dasycarpus Turcz has not acute oral toxicity and oral $LD_{50}$ value was over 4,000 mg/kg in SD rats. Also Dictamnus dasycarpus Turcz is expected to be sensitive with respect to the female.
Keywords
Acute; Dictamnus dasycarpus Turcz; herbal medicine; LD50; SD rat; toxicity;
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Times Cited By KSCI : 11  (Citation Analysis)
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