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http://dx.doi.org/10.12701/yujm.2018.35.2.141

Functional recovery after radical prostatectomy for prostate cancer  

Ko, Young Hwii (Department of Urology, Yeungnam University College of Medicine)
Publication Information
Journal of Yeungnam Medical Science / v.35, no.2, 2018 , pp. 141-149 More about this Journal
Abstract
With the enthusiasm regarding robotic application in radical prostatectomy in accordance with the widespread use of serum prostate-specific antigen as a screening test, the number of surgeries performed for complete removal of the gland is increasing continuously. However, owing to the adjacent anatomical location of the prostate to the nerve and urethral sphincter complex, functional recovery, namely improvement from post-prostatectomy incontinence (PPI) and post-prostatectomy erectile dysfunction, still remains a main problem for patients who are reluctant to undergo surgery and tend to choose alternative ways instead. Since the late 1980s, the introduction of radical prostatectomy by open surgical modalities, the depth of the anatomical understanding of the structure surrounding the prostate is getting tremendous, which leads to the development of new surgical modalities and techniques that are consequently aimed at reducing the incidences of PPI and erectile dysfunction. Briefly, recent data from robotic radical prostatectomy, particularly on PPI, are quite acceptable, but by contrast, the reported potency regain rate still remains <20%, which indicates the need for advanced surgical modification to overcome it. In this review, the authors summarized the recent findings on the anatomy and surgical techniques reported up to now.
Keywords
Erectile dysfunction; Post-prostatectomy incontinence; Prostate cancer; Radical prostatectomy; Robotic surgery;
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1 Liss MA, Osann K, Canvasser N, Chu W, Chang A, Gan J, et al. Continence definition after radical prostatectomy using urinary quality of life: evaluation of patient reported validated questionnaires. J Urol 2010;183:1464-8.   DOI
2 Ficarra V, Sooriakumaran P, Novara G, Schatloff O, Briganti A, Van der Poel H, et al. Systematic review of methods for reporting combined outcomes after radical prostatectomy and proposal of a novel system: the survival, continence, and potency (SCP) classification. Eur Urol 2012;61:541-8.   DOI
3 Kaye KW, Milne N, Creed K, van der Werf B. The ‘urogenital diaphragm', external urethral sphincter and radical prostatectomy. Aust N Z J Surg 1997;67:40-4.   DOI
4 Dorschner W, Biesold M, Schmidt F, Stolzenburg JU. The dispute about the external sphincter and the urogenital diaphragm. J Urol 1999;162:1942-5.   DOI
5 Walz J, Burnett AL, Costello AJ, Eastham JA, Graefen M, Guillonneau B, et al. A critical analysis of the current knowledge of surgical anatomy related to optimization of cancer control and preservation of continence and erection in candidates for radical prostatectomy. Eur Urol 2010;57:179-92.   DOI
6 Montorsi F, Guazzoni G, Strambi LF, Da Pozzo LF, Nava L, Barbieri L, et al. Recovery of spontaneous erectile function after nerve-sparing radical retropubic prostatectomy with and without early intracavernous injections of alprostadil: results of a prospective, randomized trial. J Urol 1997;158:1408-10.   DOI
7 Mulhall J, Land S, Parker M, Waters WB, Flanigan RC. The use of an erectogenic pharmacotherapy regimen following radical prostatectomy improves recovery of spontaneous erectile function. J Sex Med 2005;2:532-40.   DOI
8 Raina R, Agarwal A, Ausmundson S, Lakin M, Nandipati KC, Montague DK, et al. Early use of vacuum constriction device following radical prostatectomy facilitates early sexual activity and potentially earlier return of erectile function. Int J Impot Res 2006;18:77-81.   DOI
9 Walz J, Epstein JI, Ganzer R, Graefen M, Guazzoni G, Kaouk J, et al. A critical analysis of the current knowledge of surgical anatomy of the prostate related to optimisation of cancer control and preservation of continence and erection in candidates for radical prostatectomy: an update. Eur Urol 2016;70:301-11.   DOI
10 Myers RP, Cahill DR, Kay PA, Camp JJ, Devine RM, King BF, et al. Puboperineales: muscular boundaries of the male urogenital hiatus in 3D from magnetic resonance imaging. J Urol 2000;164:1412-5.   DOI
11 Sridhar AN, Abozaid M, Rajan P, Sooriakumaran P, Shaw G, Nathan S, et al. Surgical techniques to optimize early urinary continence recovery post robot assisted radical prostatectomy for prostate cancer. Curr Urol Rep 2017;18:71.   DOI
12 Kohler TS, Pedro R, Hendlin K, Utz W, Ugarte R, Reddy P, et al. A pilot study on the early use of the vacuum erection device after radical retropubic prostatectomy. BJU Int 2007;100:858-62.   DOI
13 Friedlander DF, Alemozaffar M, Hevelone ND, Lipsitz SR, Hu JC. Stepwise description and outcomes of bladder neck sparing during robot-assisted laparoscopic radical prostatectomy. J Urol 2012;188:1754-60.   DOI
14 Ma X, Tang K, Yang C, Wu G, Xu N, Wang M, et al. Bladder neck preservation improves time to continence after radical prostatectomy: a systematic review and meta-analysis. Oncotarget 2016;7:67463-75.
15 Ko YH, Coelho RF, Chauhan S, Sivaraman A, Schatloff O, Cheon J, et al. Factors affecting return of continence 3 months after robot-assisted radical prostatectomy: analysis from a large, prospective data by a single surgeon. J Urol 2012;187:190-4.   DOI
16 Reeves F, Preece P, Kapoor J, Everaerts W, Murphy DG, Corcoran NM, et al. Preservation of the neurovascular bundles is associated with improved time to continence after radical prostatectomy but not long-term continence rates: results of a systematic review and meta-analysis. Eur Urol 2015;68:692-704.   DOI
17 Takenaka A, Tewari AK, Leung RA, Bigelow K, El-Tabey N, Murakami G, et al. Preservation of the puboprostatic collar and puboperineoplasty for early recovery of urinary continence after robotic prostatectomy: anatomic basis and preliminary outcomes. Eur Urol 2007;51:433-40.   DOI
18 Rocco F, Carmignani L, Acquati P, Gadda F, Dell'Orto P, Rocco B, et al. Early continence recovery after open radical prostatectomy with restoration of the posterior aspect of the rhabdosphincter. Eur Urol 2007;52:376-83.   DOI
19 Patel VR, Coelho RF, Palmer KJ, Rocco B. Periurethral suspension stitch during robot-assisted laparoscopic radical prostatectomy: description of the technique and continence outcomes. Eur Urol 2009;56:472-8.   DOI
20 Dorschner W, Stolzenburg JU, Neuhaus J. Structure and function of the bladder neck. Adv Anat Embryol Cell Biol 2001;159:III-XII, 1-109.
21 Porpiglia F, Bertolo R, Manfredi M, De Luca S, Checcucci E, Morra I, et al. Total anatomical reconstruction during robot-assisted radical prostatectomy: implications on early recovery of urinary continence. Eur Urol 2016;69:485-95.   DOI
22 Borin JF, Skarecky DW, Narula N, Ahlering TE. Impact of urethral stump length on continence and positive surgical margins in robot-assisted laparoscopic prostatectomy. Urology 2007;70:173-7.
23 Patel VR, Samavedi S, Bates AS, Kumar A, Coelho R, Rocco B, et al. Dehydrated human amnion/chorion membrane allograft nerve wrap around the prostatic neurovascular bundle accelerates early return to continence and potency following robot-assisted radical prostatectomy: propensity score-matched analysis. Eur Urol 2015;67:977-80.   DOI
24 Ogaya-Pinies G, Palayapalam-Ganapathi H, Rogers T, Hernandez-Cardona E, Rocco B, Coelho RF, et al. Can dehydrated human amnion/chorion membrane accelerate the return to potency after a nerve-sparing robotic-assisted radical prostatectomy? Propensity score-matched analysis. J Robot Surg 2018;12:235-43.   DOI
25 Park SW, Kim TN, Nam JK, Ha HK, Shin DG, Lee W, et al. Recovery of overall exercise ability, quality of life, and continence after 12-week combined exercise intervention in elderly patients who underwent radical prostatectomy: a randomized controlled study. Urology 2012;80:299-305.   DOI
26 Mandel P, Preisser F, Graefen M, Steuber T, Salomon G, Haese A, et al. High chance of late recovery of urinary and erectile function beyond 12 months after radical prostatectomy. Eur Urol 2017;71:848-50.   DOI
27 Mulhall JP. Defining and reporting erectile function outcomes after radical prostatectomy: challenges and misconceptions. J Urol 2009;181:462-71.
28 Sridhar AN, Cathcart PJ, Yap T, Hines J, Nathan S, Briggs TP, et al. Recovery of baseline erectile function in men following radical prostatectomy for high-risk prostate cancer: a prospective analysis using validated measures. J Sex Med 2016;13:435-43.   DOI
29 Salonia A, Adaikan G, Buvat J, Carrier S, El-Meliegy A, Hatzimouratidis K, et al. Sexual rehabilitation after treatment for prostate cancer-part 2: recommendations from the fourth International Consultation for Sexual Medicine (ICSM 2015). J Sex Med 2017;14:297-315.   DOI
30 Ahlering TE, Skarecky DW. Preserving sexual function after robotic radical prostatectomy: avoiding thermal energy near nerves. BJU Int 2014;114:131-2.   DOI
31 Montorsi F, Brock G, Lee J, Shapiro J, Van Poppel H, Graefen M, et al. Effect of nightly versus on-demand vardenafil on recovery of erectile function in men following bilateral nervesparing radical prostatectomy. Eur Urol 2008;54:924-31.   DOI
32 Bannowsky A, Schulze H, van der Horst C, Hautmann S, Junemann KP. Recovery of erectile function after nerve-sparing radical prostatectomy: improvement with nightly low-dose sildenafil. BJU Int 2008;101:1279-83.   DOI
33 Padma-Nathan H, McCullough AR, Levine LA, Lipshultz LI, Siegel R, Montorsi F, et al. Randomized, double-blind, placebo-controlled study of postoperative nightly sildenafil citrate for the prevention of erectile dysfunction after bilateral nervesparing radical prostatectomy. Int J Impot Res 2008;20:479-86.   DOI
34 Pace G, Del Rosso A, Vicentini C. Penile rehabilitation therapy following radical prostatectomy. Disabil Rehabil 2010;32:1204-8.   DOI
35 Aydogdu O, Gokce MI, Burgu B, Baltaci S, Yaman O. Tadalafil rehabilitation therapy preserves penile size after bilateral nerve sparing radical retropubic prostatectomy. Int Braz J Urol 2011;37:336-44.   DOI
36 Siegel R, Ma J, Zou Z, Jemal A. Cancer statistics, 2014. CA Cancer J Clin 2014;64:9-29.   DOI
37 Ferlay J, Soerjomataram I, Dikshit R, Eser S, Mathers C, Rebelo M, et al. Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer 2015;136:E359-86.   DOI
38 Song C, Kang T, Lee MS, Ro JY, Lee SE, Lee E, et al. Clinicopathological characteristics of prostate cancer in Korean men and nomograms for the prediction of the pathological stage of the clinically localized prostate cancer: a multi-institutional update. Korean J Urol 2007;48:125-30.   DOI
39 Song K, Song C, Ahn H. Continuing trends of the clinical parameter migration in patients with prostate cancer in Korea. Korean J Urol 2007;48:574-8..   DOI
40 Klingler HC, Marberger M. Incontinence after radical prostatectomy: surgical treatment options. Curr Opin Urol 2006; 16:60-4.
41 Bannowsky A, van Ahlen H, Loch T. Increasing the dose of vardenafil on a daily basis does not improve erectile function after unilateral nerve-sparing radical prostatectomy. J Sex Med 2012;9:1448-53.   DOI
42 Montorsi F, Brock G, Stolzenburg JU, Mulhall J, Moncada I, Patel HR, et al. Effects of tadalafil treatment on erectile function recovery following bilateral nerve-sparing radical prostatectomy: a randomised placebo-controlled study (REACTT). Eur Urol 2014;65:587-96.   DOI
43 Nakano Y, Miyake H, Chiba K, Fujisawa M. Impact of penile rehabilitation with low-dose vardenafil on recovery of erectile function in Japanese men following nerve-sparing radical prostatectomy. Asian J Androl 2014;16:892-6.   DOI
44 Seo YE, Kim SD, Kim TH, Sung GT. The efficacy and safety of tadalafil 5 mg once daily in the treatment of erectile dysfunction after robot-assisted laparoscopic radical prostatectomy: 1-year follow-up. Korean J Urol 2014;55:112-9.   DOI
45 Natali A, Masieri L, Lanciotti M, Giancane S, Vignolini G, Carini M, et al. A comparison of different oral therapies versus no treatment for erectile dysfunction in 196 radical nervesparing radical prostatectomy patients. Int J Impot Res 2015;27:1-5.   DOI
46 Peterson AC, Chen Y. Patient reported incontinence after radical prostatectomy is more common than expected and not associated with the nerve sparing technique: results from the Center for Prostate Disease Research (CPDR) database. Neurourol Urodyn 2012;31:60-3.   DOI
47 Canat L, Guner B, Gurbuz C, Atis G, Caskurlu T. Effects of three-times-per-week versus on-demand tadalafil treatment on erectile function and continence recovery following bilateral nerve sparing radical prostatectomy: results of a prospective, randomized, and single-center study. Kaohsiung J Med Sci 2015;31:90-5.   DOI
48 Liu C, Lopez DS, Chen M, Wang R. Penile rehabilitation therapy following radical prostatectomy: a meta-analysis. J Sex Med 2017;14:1496-503.   DOI