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http://dx.doi.org/10.1016/j.net.2018.04.007

Dosimetric characterization and commissioning of a superficial electronic brachytherapy device for skin cancer treatment  

Park, Han Beom (Department of Nuclear and Quantum Engineering, Korea Advanced Institute of Science and Technology)
Kim, Hyun Nam (Department of Nuclear and Quantum Engineering, Korea Advanced Institute of Science and Technology)
Lee, Ju Hyuk (Department of Nuclear and Quantum Engineering, Korea Advanced Institute of Science and Technology)
Lee, Ik Jae (Department of Radiation Oncology, Gangnam Severance Hospital, Yonsei University College of Medicine)
Choi, Jinhyun (Department of Radiation Oncology, Gangnam Severance Hospital, Yonsei University College of Medicine)
Cho, Sung Oh (Department of Nuclear and Quantum Engineering, Korea Advanced Institute of Science and Technology)
Publication Information
Nuclear Engineering and Technology / v.50, no.6, 2018 , pp. 937-943 More about this Journal
Abstract
Background: This work presents the performance of a novel electronic brachytherapy (EBT) device and radiotherapy (RT) experiments on both skin cancer cells and animals using the device. Methods and materials: The performance of the EBT device was evaluated by measuring and analyzing the dosimetric characteristics of X-rays generated from the device. The apoptosis of skin cancer cells was analyzed using B16F10 melanoma cancer cells. Animal experiments were performed using C57BL/6 mice. Results: The X-ray characteristics of the EBT device satisfied the accepted tolerance level for RT. The results of the RT experiments on the skin cancer cells show that a significant apoptosis induction occurred after irradiation with 50 kVp X-rays generated from the EBT device. Furthermore, the results of the animal RT experiments demonstrate that the superficial X-rays significantly delay the tumor growth and that the tumor growth delay induced by irradiation with low-energy X-rays was almost the same as that induced by irradiation with a high-energy electron beam. Conclusions: The developed new EBT device has almost the same therapeutic effect on the skin cancer with a conventional linear accelerator. Consequently, the EBT device can be practically used for human skin cancer treatment in the near future.
Keywords
Carbon Nanotube; Electronic Brachytherapy; Miniature X-ray Tube; Radiotherapy Experiments; Skin Cancer;
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