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PREPARATION OF N-(3-BROMO-2,4,6-TRIMETHYLACETANILIDE)IMINODIACETIC ACID AND ITS ${99M}^TC$-COMPLEX FOR HEPATOBILIARY IMAGING  

CHOI OK-JA (Korea Atomic Energy Research Institute)
HONG YOUNG-DON (Korea Atomic Energy Research Institute)
GWON HUI-JEONG (Korea Atomic Energy Research Institute)
CHOI SANG-MU (Korea Atomic Energy Research Institute)
CHOI SUN-JU (Korea Atomic Energy Research Institute)
Publication Information
Nuclear Engineering and Technology / v.37, no.4, 2005 , pp. 391-394 More about this Journal
Abstract
N-(3-bromo-2,4,6-trimethylacetanilide)iminodiacetic acid (BrTIDA) was synthesized using nitrilotriacetic anhydride prepared in situ, and lyophilized vials were prepared which contained 20 mg of BrTIDA and 0.4 mg of $SnCl_2$. To evaluate the clinical efficacy of the in-house prepared lyophilized kit, a technetium-99m complex of BrTIDA was prepared; its in vivo pharmacokinetic behavior was evaluated via animal studies to assess the hepatocytic function and the functional status of the cystic duct and the gallbladder. Serial static image scans of rabbits and the biodistribution in mice injected with $^{99m}Tc-BrTIDA$ revealed that none of the tissues except for the hepatobiliary system showed radioactivity concentrations, and a rapid clearance from the organs was observed. In conclusion, a lyophilized kit and its prepared $^{99m}Tc-BrTIDA$ can be applied as a hepatobiliary imaging agent for the evaluation of the functional status of the hepatocytes and the patency of the biliary duct.
Keywords
Cholescintigraphy; Hepatobiliary Imaging; BrTIDA; Nitrilotriacetic Anhydride;
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