Browse > Article
http://dx.doi.org/10.12812/ksms.2012.14.1.043

A Study on Toxicity Bio-markers of a Mouse using Combustion Gas SO2 generated from Fire  

Rie, Dong-Ho (Fire Disaster Protection Research Center, University of Incheon)
Cho, Nam-Wook (korea Institute of Construction Technology(KICT))
Choi, Soon-Young (Fire Disaster Protection Research Center, University of Incheon)
Publication Information
Journal of the Korea Safety Management & Science / v.14, no.1, 2012 , pp. 43-51 More about this Journal
Abstract
This study was carried out to observe the impacts of a mouse's inhalation of toxic gas SO2 generated from combustion on its organs by different concentrations. As for research methods: First, after concentrations of SO2 generation from combustion had been set to three: low (10.4 ppm), middle (24.9 ppm) and high (122 ppm) through Gas Toxicity Testing Method (KS F 2271) and SO2 combustion gas was exposed to eight mice in each concentration. Five mice that were able to move based on LD50, a criterion, which sets the down time of a mouse's average behaviors to over 9 minutes, were randomly selected in each concentration, and they were set up as the subjects of the study on toxicity bio-markers. Second, tissues were taken from heart, liver, lungs, spleen and the thymus gland of the mice selected in each concentration and a pathological examination of them was carried out. As a result, microvascular congestion appeared in the heart, and cell necrosis, cortex congestion and tubule medulla congestion, etc. in each concentration were observed in addition to vascular congestion in liver, lungs, spleen and the thymus gland. Also, it was found that the higher the concentrations of SO2 exposure is, the greater, the changes in the organs get. Through this study, SO2 of various toxic gases generated from fire turned out to affect the tissues of each organ of a mouse, it is expected that the toxic gases may greatly affect human body in case of actual fire, and this study is evaluated as having a significance as a basic data on inhalation toxicity assessment of toxic substances generated in combustion.
Keywords
Fire; Combustion gas; Toxic gas; Toxicity bio-markers; SO2; Mouse;
Citations & Related Records
Times Cited By KSCI : 2  (Citation Analysis)
연도 인용수 순위
1 김만철, 김병석, "초고층 건축물 소방안전관리의 기본방향에 관한 연구", 대한안전경영과학회지, 13(2), (2011): 67-75.
2 소방방재청, "2011 상반기 화재발생현황 분석", 소방방재청, (2011): 1-4.
3 곽성근, "기능․난연성 무기재료 개발 및 이를 이용한 건축 재료에 관한 연구", 경일대학교 석사학위논문, (2009): 1-2.
4 이인구, 조남욱, 이봉재, 이동호, "Smoke density chamber를 적용한 건축물 마감재의 연소가스 독성 평가", 한국화재소방학회 학술대회 논문집, (4), (2011): 248-251.
5 조남욱, 이종천, 이동호, "연소독성지수와 마우스 행동정시시간 비교 연구" 한국화재소방학회논문지, 25(4), (2011): 35-41
6 KS F 2271, 건축물의 내장재료 및 구조의 난연성 시험방법, 한국표준협회, (1998).
7 이장원, 이봉우, 권성필, 이병호, 김희수, 김현중, "콘칼로리미터를 이용한 건축 바닥재의 연소거동과 가스 유해성 평가", Mokchae Konghak, 36(1), (2008): 45-53.
8 신동일, 원동빈, "방염물질의 화재시 가스유해성 예측 및 평가 Tool", Theories and Applications of Chem. Eng, 13(1), (2007): 1209
9 박영주, 이해평, 김해림, 이원석, 양영숙, 이미리, "건축용 외장재의 연소가스 독성평가", 한국화재소방학회 학술대회 논문집, (4), (2011): 441-446
10 한국산업안전보건공단(www.kosha.or.kr), MSDS (물질안전보건자료).
11 M. Yoshida, J. Adachi, T. Watabiki, Y. Tatsuno, N. Ishida, "A study on house fire victims: age, carboxyhemoglobin, hydrogen cyanide and hemolysis", Forensic Science International, 52(1), (1991): 13-20.   DOI
12 Leopoldo C Cancio, "Current concepts in the pathophysiology and treatment of inhalation injury", Trauma, (7), (2005): 19-35.   DOI
13 Anderson RA, Watson AA, Harland WA, "Fire deaths in the Glasgow area: I General considerations and pathology" Med Sci Law, 21(3), (1981): 175-83.
14 WHO, "Environmental Health Criteria 10", Carbon disulphide, Geneva, (1979).
15 Wood R, "Neurobehavier toxicity of carbon dislfide", Neurobehav Toxicol Teratol , 3, (1981): 397-405.
16 김치년, 조영봉, 문영한, 노재훈, "이황화탄소의 요중대사물질에 관한 연구. 대한산업의학회지, 4(2), (1992): 133-143.