Browse > Article
http://dx.doi.org/10.5808/GI.2015.13.4.152

Building the Frequency Profile of the Core Promoter Element Patterns in the Three ChromHMM Promoter States at 200bp Intervals: A Statistical Perspective  

Lent, Heather (Bioinformatics Laboratory, School of Engineering, Ewha Womans University)
Lee, Kyung-Eun (Bioinformatics Laboratory, School of Engineering, Ewha Womans University)
Park, Hyun-Seok (Bioinformatics Laboratory, School of Engineering, Ewha Womans University)
Abstract
Recently, the Encyclopedia of DNA Elements (ENCODE) Analysis Working Group converted data from ChIP-seq analyses from the Broad Histone track into 15 corresponding chromatic maps that label sequences with different kinds of histone modifications in promoter regions. Here, we publish a frequency profile of the three ChromHMM promoter states, at 200-bp intervals, with particular reference to the existence of sequence patterns of promoter elements, GC-richness, and transcription starting sites. Through detailed and diligent analysis of promoter regions, researchers will be able to uncover new and significant information about transcription initiation and gene function.
Keywords
chromatin state; epigenetics; epigenomics; genetic promoter regions;
Citations & Related Records
Times Cited By KSCI : 1  (Citation Analysis)
연도 인용수 순위
1 ENCODE Project Consortium. The ENCODE (ENCyclopedia Of DNA Elements) Project. Science 2004;306:636-640.   DOI
2 ENCODE Project Consortium. An integrated encyclopedia of DNA elements in the human genome. Nature 2012;489:57-74.   DOI
3 Ernst J, Kellis M. Discovery and characterization of chromatin states for systematic annotation of the human genome. Nat Biotechnol 2010;28:817-825.   DOI
4 Ernst J, Kheradpour P, Mikkelsen TS, Shoresh N, Ward LD, Epstein CB, et al. Mapping and analysis of chromatin state dynamics in nine human cell types. Nature 2011;473:43-49.   DOI
5 Park HS, Galbadrakh B, Kim YM. Recent progresses in the linguistic modeling of biological sequences based on formal language theory. Genomics Inform 2011;9:5-11.   DOI
6 Datta S, Mukhopadhyay S. A composite method based on formal grammar and DNA structural features in detecting human polymerase II promoter region. PLoS One 2013;8:e54843.   DOI
7 Yamashita R, Sugano S, Suzuki Y, Nakai K. DBTSS: DataBase of transcriptional start sites progress report in 2012. Nucleic Acids Res 2012;40:D150-D154.   DOI
8 Yamashita R, Sathira NP, Kanai A, Tanimoto K, Arauchi T, Tanaka Y, et al. Genome-wide characterization of transcriptional start sites in humans by integrative transcriptome analysis. Genome Res 2011;21:775-789.   DOI