Browse > Article
http://dx.doi.org/10.5808/GI.2013.11.1.7

Perspectives of International Human Epigenome Consortium  

Bae, Jae-Bum (Division of Structural and Functional Genomics, Center for Genome Sciences, Korea National Institute of Health)
Abstract
As the International Human Epigenome Consortium (IHEC) launched officially at the 2010 Washington meeting, a giant step toward the conquest of unexplored regions of the human genome has begun. IHEC aims at the production of 1,000 reference epigenomes to the international scientific community for next 7-10 years. Seven member institutions, including South Korea, Korea National Institute of Health (KNIH), will produce 25-200 reference epigenomes individually, and the produced data will be publically available by using a data center. Epigenome data will cover from whole genome bisulfite sequencing, histone modification, and chromatin access information to miRNA-seq. The final goal of IHEC is the production of reference maps of human epigenomes for key cellular status relevant to health and disease.
Keywords
chromatin; DNA methylayion; histones; methylome; microRNAs;
Citations & Related Records
연도 인용수 순위
  • Reference
1 Jones PA, Martienssen R. A blueprint for a Human Epigenome Project: the AACR Human Epigenome Workshop. Cancer Res 2005;65:11241-11246.   DOI   ScienceOn
2 American Association for Cancer Research Human Epigenome Task Force; European Union, Network of Excellence, Scientific Advisory Board. Moving AHEAD with an international human epigenome project. Nature 2008;454:711-715.   DOI   ScienceOn
3 NIH roadmap epigenomics. Bethesda: National Center for Biotechnology Information. Accessed 2013 Jan 30. Available from: http://www.roadmapepigenomics.org.
4 International Human Epigenome Consortium (IHEC). International Human Epigenome Consortium. Accessed 2013 Jan 30. Available from: http://www.IHEC-epigenomes.net.
5 Bernstein BE, Stamatoyannopoulos JA, Costello JF, Ren B, Milosavljevic A, Meissner A, et al. The NIH Roadmap Epigenomics Mapping Consortium. Nat Biotechnol 2010;28:1045-1048.   DOI   ScienceOn
6 Blueprint Epigenome. Nijmegen: Blueprint Epigenome. Accessed 2013 Jan 30. Available from: http://www.blueprint- epigenome.eu/.
7 Challis D, Yu J, Evani US, Jackson AR, Paithankar S, Coarfa C, et al. An integrative variant analysis suite for whole exome next-generation sequencing data. BMC Bioinformatics 2012;13:8.   DOI   ScienceOn
8 Lian CG, Xu Y, Ceol C, Wu F, Larson A, Dresser K, et al. Loss of 5-hydroxymethylcytosine is an epigenetic hallmark of melanoma. Cell 2012;150:1135-1146.   DOI   ScienceOn
9 Rakyan VK, Down TA, Balding DJ, Beck S. Epigenome-wide association studies for common human diseases. Nat Rev Genet 2011;12:529-541.   DOI   ScienceOn
10 Lister R, Pelizzola M, Dowen RH, Hawkins RD, Hon G, Tonti-Filippini J, et al. Human DNA methylomes at base resolution show widespread epigenomic differences. Nature 2009;462:315-322.   DOI   ScienceOn
11 Lister R, Pelizzola M, Kida YS, Hawkins RD, Nery JR, Hon G, et al. Hotspots of aberrant epigenomic reprogramming in human induced pluripotent stem cells. Nature 2011;471:68-73.   DOI   ScienceOn
12 Maurano MT, Humbert R, Rynes E, Thurman RE, Haugen E, Wang H, et al. Systematic localization of common disease- associated variation in regulatory DNA. Science 2012; 337:1190-1195.   DOI   ScienceOn
13 Sandhu KS, Li G, Poh HM, Quek YL, Sia YY, Peh SQ, et al. Large-scale functional organization of long-range chromatin interaction networks. Cell Rep 2012;2:1207-1219.   DOI   ScienceOn
14 Flusberg BA, Webster DR, Lee JH, Travers KJ, Olivares EC, Clark TA, et al. Direct detection of DNA methylation during single-molecule, real-time sequencing. Nat Methods 2010;7: 461-465.   DOI   ScienceOn
15 Wu SC, Zhang Y. Active DNA demethylation: many roads lead to Rome. Nat Rev Mol Cell Biol 2010;11:607-620.   DOI   ScienceOn
16 Meyer KD, Saletore Y, Zumbo P, Elemento O, Mason CE, Jaffrey SR. Comprehensive analysis of mRNA methylation reveals enrichment in 3' UTRs and near stop codons. Cell 2012;149:1635-1646.   DOI   ScienceOn
17 Zhang J, Poh HM, Peh SQ, Sia YY, Li G, Mulawadi FH, et al. ChIA-PET analysis of transcriptional chromatin interactions. Methods 2012;58:289-299.   DOI   ScienceOn