Polymorphisms in RAS Guanyl-releasing Protein 3 are Associated with Chronic Liver Disease and Hepatocellular Carcinoma in a Korean Population |
Oh, Ah-Reum
(Medical Genomics Laboratory, Graduate School of Life Science and Biotechnology, Pochon CHA University)
Lee, Seung-Ku (Medical Genomics Laboratory, Graduate School of Life Science and Biotechnology, Pochon CHA University) Kim, Min-Ho (Medical Genomics Laboratory, Graduate School of Life Science and Biotechnology, Pochon CHA University) Cheong, Jae-Youn (Department of Gastroenterology, Genomic Research Center for Gastroenterology, Ajou University School of Medicine) Cho, Sung-Won (Department of Gastroenterology, Genomic Research Center for Gastroenterology, Ajou University School of Medicine) Yang, Kap-Seok (Macrogen Inc.) Kwack, Kyu-Bum (Medical Genomics Laboratory, Graduate School of Life Science and Biotechnology, Pochon CHA University) |
1 | Jung, H.Y., Park, J.S., Park, Y.J., Kim, Y.J., Kimm, K.C., and Koh, I.S. (2004). HapAnalyzer: minimum haplotype analysis system for association studies. Genomics & Informatics 2, 107-109 과학기술학회마을 |
2 | Laurent-Puig, P., and Zucman-Rossi, J. (2006). Genetics of hepatocellular tumors. Oncogene 25, 3778-3786 DOI ScienceOn |
3 | Levy-Lahad, E., and Friedman, E. (2007). Cancer risks among BRCA1 and BRCA2 mutation carriers. Br. J. Cancer 96, 11-15 DOI ScienceOn |
4 | Lee, S.K., Kim, H.G., Kang, J.J., Oh, W., Oh, B.E., and Kwack, K. (2007). Characterization of single nucleotide polymorphisms in 55disease-associated genes in a Korean population. Genomics & informatics 5, 152-160 과학기술학회마을 |
5 | Park, B.L., Kim, Y.J., Cheong, H.S., Lee, S.O., Han, C.S., Yoon, J.H., Park, J.H., Chang, H.S., Park, C.S., Lee, H.S., and Shin, H.D. (2007). HDAC10 promoter polymorphism associated with development of HCC among chronic HBV patients. Biochem. Biophys. Res. Commun. 363, 776-781 DOI ScienceOn |
6 | Parkin, D.M., Bray, F., Ferlay, J., and Pisani, P. (2001). Estimating the world cancer burden: Globocan 2000. Int. J. Cancer 94, 153-156 DOI ScienceOn |
7 | Tsuboi, Y., Ichida, T., Sugitani, S., Genda, T., Inayoshi, J., Takamura, M., Matsuda, Y., Nomoto, M., and Aoyagi, Y. (2004). Overexpression of extracellular signal-regulated protein kinase and its correlation with proliferation in human hepatocellular carcinoma. Liver Int. 24, 432-436 DOI ScienceOn |
8 | Wang, Q., Lin, Z.Y., and Feng, X.L. (2001). Alterations in metastatic properties of hepatocellular carcinoma cell following H-ras oncogene transfection. World J. Gastroenterol. 7, 335-339 DOI |
9 | Aiba, Y., Oh-hora, M., Kiyonaka, S., Kimura, Y., Hijikata, A., Mori, Y., and Kurosaki, T. (2004). Activation of RasGRP3 by phosphorylation of Thr-133 is required for B cell receptor- mediated Ras activation. Proc. Natl. Acad. Sci. U. S. A. 101, 16612-16617 DOI ScienceOn |
10 | Bar-Sagi, D., and Hall, A. (2000). Ras and Rho GTPases: a family reunion. Cell 103, 227-38 DOI ScienceOn |
11 | Bruix, J., Boix, L., Sala, M., and Llovet, J.M. (2004). Focus on hepatocellular carcinoma. Cancer Cell 5, 215-219 DOI ScienceOn |
12 | Caselmann, W.H. (1998). Pathogenesis of hepatocellular carcinoma. Digestion 59 Suppl 2, 60-63 |
13 | Greenblatt, M.S., Bennett, W.P., Hollstein, M., and Harris, C.C. (1994). Mutations in the p53 tumor suppressor gene: clues to cancer etiology and molecular pathogenesis. Cancer Res. 54, 4855-4878 |
14 | Coughlin, J.J., Stang, S.L., Dower, N.A., and Stone, J.C. (2005). RasGRP1 and RasGRP3 regulate B cell proliferation by facilitating B cell receptor-Ras signaling. J. Immunol. 175, 7179-84 DOI |
15 | Crepieux, P., Kwon, H., Leclerc, N., Spencer, W., Richard, S., Lin, R., and Hiscott, J. (1997). I kappaB alpha physically interacts with a cytoskeleton-associated protein through its signal response domain. Mol. Cell. Biol. 17, 7375-7385 DOI |
16 | Edmondson, H.A., Henderson, B., and Benton, B. (1976). Liver-cell adenomas associated with use of oral contraceptives. N. Engl. J. Med. 294, 470-472 DOI ScienceOn |
17 | Ito, Y., Sasaki, Y., Horimoto, M., Wada, S., Tanaka, Y., Kasahara, A., Ueki, T., Hirano, T., Yamamoto, H., Fujimoto, J., Okamoto, E., Hayashi, N., and Hori, M. (1998). Activation of mitogen-activated protein kinases/extracellular signal-regulated kinases in human hepatocellular carcinoma. Hepatology 27, 951-958 DOI ScienceOn |
18 | Roberts, D.M., Anderson, A.L., Hidaka, M., Swetenburg, R.L., Patterson, C., Stanford, W.L., and Bautch, V.L. (2004). A vascular gene trap screen defines RasGRP3 as an angiogenesis-regulated gene required for the endothelial response to phorbol esters. Mol. Cell. Biol. 24, 10515-10528 DOI ScienceOn |
19 | Puthalakath, H., Huang, D.C., O'Reilly, L.A., King, S.M., and Strasser, A. (1999). The proapoptotic activity of the Bcl-2 family member Bim is regulated by interaction with the dynein motor complex. Mol. Cell. 3, 287-296 DOI ScienceOn |
20 | Shields, J.M., Pruitt, K., McFall, A., Shaub, A., and Der, C.J. (2000). Understanding Ras: 'it ain't over 'til it's over'. Trends Cell Biol. 10, 147-154 DOI ScienceOn |
21 | Bosch, F.X., Ribe, J., Diaz, M., and Cleries, R. (2004). Primary liver cancer: worldwide incidence and trends. Gastroenterology 127, S5-S16 DOI |
22 | Schmidt, C.M., McKillop, I.H., Cahill, P.A., and Sitzmann, J.V. (1997). Increased MAPK expression and activity in primary human hepatocellular carcinoma. Biochem Biophys. Res. Commun. 236, 54-58 DOI ScienceOn |
23 | Vojtek, A.B., and Der, C.J. (1998). Increasing complexity of the Ras signaling pathway. J. Biol. Chem. 273, 19925- 19928 DOI ScienceOn |
24 | Tangye, S.G., and Hodgkin, P.D. (2004). Divide and conquer: the importance of cell division in regulating B-cell responses. Immunology 112, 509-520 DOI ScienceOn |
25 | Arbuthnot, P., and Kew, M. (2001). Hepatitis B virus and hepatocellular carcinoma. Int. J. Exp. Pathol. 82, 77-100. DOI ScienceOn |
26 | Lewis, C.M. (2002). Genetic association studies: design, analysis and interpretation. Brief Bioinform 3, 146-153 DOI ScienceOn |
27 | Khosravi-Far, R., and Der, C.J. (1994). The Ras signal transduction pathway. Cancer Metastasis Rev. 13, 67-89 DOI |
28 | Kirk, G.D., Lesi, O.A., Mendy, M., Szymanska, K., Whittle, H., Goedert, J.J., Hainaut, P., and Montesano, R. (2005). 249(ser) TP53 mutation in plasma DNA, hepatitis B viral infection, and risk of hepatocellular carcinoma. Oncogene 24, 5858-5867 DOI ScienceOn |
29 | Cha, C., and Dematteo, R.P. (2005). Molecular mechanisms in hepatocellular carcinoma development. Best Pract. Res. Clin Gastroenterol 19, 25-37 DOI ScienceOn |
30 | Lorenzo, P.S., Kung, J.W., Bottorff, D.A., Garfield, S.H., Stone, J.C., and Blumberg, P.M. (2001). Phorbol esters modulate the Ras exchange factor RasGRP3. Cancer Res. 61, 943-9 |
31 | Nonomura, A., Ohta, G., Hayashi, M., Izumi, R., Watanabe, K., Takayanagi, N., Mizukami, Y., and Matsubara, F. (1987). Immunohistochemical detection of ras oncogene p21 product in liver cirrhosis and hepatocellular carcinoma. Am. J. Gastroenterol. 82, 512-518 |
32 | Mitin, N., Rossman, K.L., and Der, C.J. (2005). Signaling interplay in Ras superfamily function. Curr. Biol. 15(14), R563-R574 DOI ScienceOn |
33 | Rebhun, J.F., Castro, A.F., and Quilliam, L.A. (2000). Identification of guanine nucleotide exchange factors (GEFs) for the Rap1 GTPase. Regulation of MR-GEF by M-Ras-GTP interaction. J. Biol. Chem. 275, 34901-34908 DOI ScienceOn |
34 | Wu, L.M., Zhang, F., Xie, H.Y., Xu, X., Chen, Q.X., Yin, S.Y., Liu, X.C., Zhou, L., Xu, X.B., Sun, Y.L., and Zheng, S.S. (2008). MMP2 promoter polymorphism (C-1306T) and risk of recurrence in patients with hepatocellular carcinoma after transplantation. Clin. Genet. 73, 273-278 DOI ScienceOn |
35 | Pang, R., Yuen, J., Yuen, M.F., Lai, C.L., Lee, T.K., Man, K., Poon, R.T., Fan, S.T., Wong, C.M., Ng, I.O., Kwong, Y.L., and Tse, E. (2004). PIN1 overexpression and beta- catenin gene mutations are distinct oncogenic events in human hepatocellular carcinoma. Oncogene 23, 4182- 4186 DOI ScienceOn |
![]() |