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http://dx.doi.org/10.14475/kjhpc.2015.18.2.120

Relationship between Vitamin D Level and Survival in Terminally III Cancer Patients  

Choi, Sun Young (Department of Family Medicine, Catholic Kwandong University College of Medicine, International ST. Mary's Hospital)
Choi, Youn Seon (Korea University College of Medicine, Guro Hospital)
Hwang, In Cheol (Gachon University of Medicine and Science, Gil Medical Center)
Lee, June Young (Department of Biostatistics, Korea University College of Medicine)
Publication Information
Journal of Hospice and Palliative Care / v.18, no.2, 2015 , pp. 120-127 More about this Journal
Abstract
Purpose: We aimed to investigate how serum vitamin D levels are related to survival of terminally ill cancer patients. Methods: From May 2012 through June 2013, a retrospective chart review was performed on 96 hospice patients. Univariate and multivariate logistic regression analyses were conducted to identify factors associated with severe vitamin D deficiency and Coxcy and Coxional hazard analyses were used to evaluate effects on survival. Results: The mean vitamin D level in patients was $8.60{\pm}7.16ng/ml$. Vitamin D was severely deficient (<10 ng/ml) in 75 patients (78.2%), deficient (10~20 ng/ml) in 13 patients (13.5%), relatively insufficient (21~29 ng/ml) in five patients (8.3%) and sufficient ((t ng/ml) in three patients (3.1%). Hyperbilirubinemia (${\geq}1.2g/dl$) was the only factor associated with severe vitamin D deficiency according to the multiple logistic regression analysis (Odds ratio, OR=18.48, P<0.05). Although hyperbilirubinemia showed a strong association with survival (Hazard ratio, HR=2.25, P<0.01), no association was found between severe vitamin D deficiency and survival (HR=1.15, P>0.05) in Cox's proportional hazard analysis. Conclusion: Although serum vitamin D levels were severely low in terminally ill cancer patients, we found no association between severe vitamin D deficiency and patient survival.
Keywords
Vitamin D; Terminal care; Survival analysis; Hospices;
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