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http://dx.doi.org/10.15207/JKCS.2022.13.04.573

Evaluation of the efficacy of modified Samultang in female menopausal animal models using ovarian resection rats  

Hwang, Seonghee (School of Biofood and Nutrition, Semyung University)
Park, Sunyoung (College of Korean Medicin, Semyung University)
Shin, Yong Kook (School of Industrial Bio-Pharmaceutical Science, Semyung University)
Publication Information
Journal of the Korea Convergence Society / v.13, no.4, 2022 , pp. 573-582 More about this Journal
Abstract
In order to develop samultang with reduced side effects, modified samultang using omija was oral administered to rats with ovarian resection, and changes in evaluation indicators of functional efficacy in women's menopause were measured. In weight gain, relative weight of uterus and vagina, blood lipid-related indicators, and changes in blood estradiol, there was no statistically significant improvement effect in modified Samultang compared to the control group. However, the expression of estrogen receptor alpha and beta in intrauterine tissue tended to increase, and the expression of phosphorylated ERK, which is known to be involved in estrogen receptor signaling, showed a significant increase in activation in ERK and AKT. The expression amount of phosphorylation AKT was not significant, but showed an increasing tendency. Even though the test substance was administered in a relatively small dose, it is judged that the test substance modified Samultang has the ability to activate estrogen receptor. In the future, it is expected that it can be used as a useful natural mixture to show the efficacy of samultang with fewer gastrointestinal disorders.
Keywords
Modified Samultang; the evaluation index of functional efficacy in female menopause; the expression of estrogen receptor; the expression of phosphorylated ERK; the expression of phosphorylated AKT;
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