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http://dx.doi.org/10.15207/JKCS.2021.12.8.179

Brief Review on the Processes for RNA-Platform Vaccine Production  

Roh, Hyungmin (Department of Chemical and Environmental Technology, Inha Technical College)
Oh, Kyeongseok (Department of Chemical and Environmental Technology, Inha Technical College)
Publication Information
Journal of the Korea Convergence Society / v.12, no.8, 2021 , pp. 179-186 More about this Journal
Abstract
Among the Covid-19 vaccine platforms, mRNA-platform vaccines are summarized qualitatively in this paper. Manufacturing mRNA vaccines consist of serial processes; the preparation process of DNA template, the transcription of mRNA, nanoemulsion process, and the fill and finish unit combined with formulation stages. It is noticeable that major players are collaborated for producing mRNA vaccines. In particular, the nanoemulsion process is recognized to the key process requiring formulated lipid materials to protect modified mRNA until they arrive in intracellular cytosol. It is known that the nanoemulsion process adapts well-designed microfluidic devices. We expect that the nanoemulsion process will stimulate pharmaceutical industries to develop diverse applications.
Keywords
COVID-19; mRNA vaccine; nanoemulsion; microfluidic device; bioprocess;
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