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http://dx.doi.org/10.15207/JKCS.2021.12.2.295

Effect of Celeriac Extract on the LPS-Induced Production of Pro-inflammatory Cytokines by RAW 264.7 cells  

Lee, Jae-Hyeok (Department of Emergency Medical Rescue, Nambu University)
Jeong, Hyun-Ju (Department of Nursing, Nambu University)
Park, Jeong-Sook (Department of Nursing, Nambu University)
Publication Information
Journal of the Korea Convergence Society / v.12, no.2, 2021 , pp. 295-300 More about this Journal
Abstract
This study was conducted to investigate the effect of Celeriac Extract on the production of pro-inflammatory cytokines. Inflammation is caused by pro-inflammatory cytokines TNF-α, IL-6, IL-1β and mediators such as free radicals. We investigated the effect of Celeriac Extract (1ug/mL, 10ug/mL, 100ug/mL) on the production of proinflammatory cytokines such as TNF-α, IL-6, IL-1β and NO by lipopolysaccharide (LPS)-stimulated RAW 264.7 cells. These results demonstrated that Celeriac Extract inhibited the production of TNF-α, IL-6 and NO, without cytotoxicity significantly. Therefore, these findings suggest that Celeriac Extract may attenuate inflammatory responses via inhibition of production of pro-inflammatory cytokines and NO.
Keywords
Celeriac; Inflammation; Cytokine; NO; TNF-${\alpha}$;
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