Browse > Article
http://dx.doi.org/10.15207/JKCS.2020.11.10.155

Relationship between Body Mass Index and Insulin Resistance and Beta Cell Function by Obesity Type in Obese Middle-Aged Men  

Shin, Kyung-A (Dept. of Clinical Laboratory Science, Shinsung University)
Publication Information
Journal of the Korea Convergence Society / v.11, no.10, 2020 , pp. 155-162 More about this Journal
Abstract
This study wanted to confirm the relevance between body mass index(BMI) and insulin resistance and beta-cell function based on abdominal obesity in obese middle-aged men. This study targeted 797 obese middle-aged men who had undergone health checkups at general hospitals in Gyeonggi-do from January 2018 to June 2020. There were 327 in the group with abdominal obesity and 470 in the group without abdominal obesity. Glucose(p<0.001), HbA1c(p=0.003), insulin(p<0.001), HOMA-IR(p<0.001) was different between groups. BMI was a factor affecting insulin resistance and beta cell function regardless of the with or without of abdominal obesity. BMI was associated with the onset of disease of insulin resistance and beta cell functional degradation regardless of the with or without of abdominal obesity. Therefore, it is considered necessary to manage the indicators of the BMI through exercise programs and regular checkups for health management of middle-aged obese men.
Keywords
Body mass index; Insulin resistance; Beta cell function; Obesity type; Convergence;
Citations & Related Records
연도 인용수 순위
  • Reference
1 R. M. Krauss, M. Winston, R. N. Fletcher & S. M. Grundy. (1998). Obesity: impact of cardiovascular disease. Circulation, 98(14), 1472-1476. DOI: https://doi.org/10.1161/01.cir.98.14.1472   DOI
2 T. L. Visscher & J. C. Seidell. (2001). The public health impact of obesity. Annual Review of Public Health, 22, 355-375. DOI: 10.1146/annurev.publhealth.22.1.355   DOI
3 T. Okura et al. (2018). Body mass index ${\geq}$23 is a risk factor for insulin resistance and diabetes in Japanese people: A brief report. Public Library of Science One, 13(7), e0201052. DOI: 10.1371/journal.pone.0201052
4 P. Poirier et al. (2006). Obesity and cardiovascular disease: pathophysiology, evaluation, and effect of weight loss: an update of the 1997 American Heart Association Scientific Statement on Obesity and Heart Disease from the Obesity Committee of the Council on Nutrition, Physical Activity, and Metabolism. Circulation, 113(6), 898-918. DOI: 10.1161/CIRCULATIONAHA.106.171016   DOI
5 G. A. Colditz et al. (1990). Weight as a risk factor for clinical diabetes in women. American Journal of Epidemiology, 132(3), 501-513. DOI: 10.1093/oxfordjournals.aje.a115686   DOI
6 G. H. Brody, T. Yu, E. Chen, K. B. Ehrlich & G. E. Miller. (2018). Racial discrimination, body mass index, and insulin resistance: A longitudinal analysis. Health Psychology, 37(12), 1107-1114. DOI: 10.1037/hea0000674   DOI
7 K. Ah Kim & M. S. Lee. (2010). Role and mechanism of pancreatic $\beta$-cell death in diabetes: The emerging role of autophagy. Journal of Diabetes Investigation, 1(6), 232-238. DOI: 10.1111/j.2040-1124.2010.00054.x   DOI
8 F. X. Pi-Sunyer. (1993). Medical hazards of obesity. Annals of Internal Medicine, 119(7 Pt 2), 655-660. DOI: 10.7326/0003-4819-119-7_part_2-199310011-00006   DOI
9 P. Abelson & D. Kennedy. (2004). The obesity epidemic. Science, 304(5676), 1413. DOI: 10.1126/science.304.5676.1413   DOI
10 P. T. James, R. Leach, E. Kalamara & M. Shayeghi. (2001). The worldwide obesity epidemic. Obesity Research, 9(Suppl 4), 228S-233S. DOI: 10.1038/oby.2001.123   DOI
11 F. X. Pi-Sunyer. (1999). Comorbidities of overweight and obesity: current evidence and research issues. Medicine & Science in Sports & Exercise, 31(11 Suppl), 602-608. DOI: 10.1097/00005768-199911001-00019
12 F. W. Booth, S. E. Gordon, C. J. Carlson & M. T. Hamilton. (2000). Waging war on modern chronic diseases: primary prevention through exercise biology. Journal of Applied Physiology, 88(2), 774-787. DOI: 10.1152/jappl.2000.88.2.774   DOI
13 E. J. Rhee et al. (2018). Association between abdominal obesity and increased risk for the development of hypertension regardless of physical activity: A nationwide population-based study. Journal of Clinical Hypertension (Greenwich), 20(10), 1417-1426. DOI: 10.1111/jch.13389   DOI
14 A. Pascot et al. (2000). Contribution of visceral obesity to the deterioration of the metabolic risk profile in men with impaired glucose tolerance. Diabetologia, 43(9), 1126-1135. DOI: 10.1007/s001250051503   DOI
15 A. Rodriguez-Campello et al. (2017). Sex-related differences in abdominal obesity impact on ischemic stroke risk. European Journal of Neurology, 24(2), 397-403. DOI: 10.1111/ene.13216   DOI
16 R. C. Bonadonna & R. A. De Fronzo. (1991). Glucose metabolism in obesity and type 2 diabetes. Diabetes and Metabolism, 17(1 Pt 2), 112-135.
17 World Health Organization. (2000). The Asia-Pacific perspective: redefining obesity and its treatment. Sydney : Health Communications Australia.
18 S. Lee et al. (2006). Cutoff values of surrogate measures of insulin resistance for metabolic syndrome in Korean non-diabetic adults. Journal of Korean Medical Science, 21(4), 695-700. DOI: 10.3346/jkms.2006.21.4.695   DOI
19 Y. Song et al. (2007). Insulin sensitivity and insulin secretion determined by homeostasis model assessment and risk of diabetes in a multiethnic cohort of women: the women's health initiative observational study. Diabetes Care, 30(7), 1747-1752. DOI: 10.2337/dc07-0358   DOI
20 G. Chen et al. (2010). Overweight, obesity, and their associations with insulin resistance and $\beta$-cell function among Chinese: a cross-sectional study in China. Metabolism, 59(12), 1823-1832. DOI: 10.1016/j.metabol.2010.06.009   DOI
21 E. J. Sung, S. Sunwoo, S. W. Kim & Y. S. Kim. (2001). Obesity as a risk factor for non-insulin-dependent diabetes mellitus in Korea. Journal of Korean Medical Science, 16(4), 391-396. DOI: 10.3346/jkms.2001.16.4.391   DOI
22 D. T. Finegood, I. M. Hramiak & J. Dupre. (1990). A modified protocol for estimation of insulin sensitivity with the minimal model of glucose kinetics in patients with insulin-dependent diabetes. Journal of Clinical Endocrinology and Metabolism, 70(6), 1538-1549. DOI: 10.1210/jcem-70-6-1538   DOI
23 M. P. Hermans, J. C. Levy, R. J. Morris & R. C. Turner. (1999). Comparison of tests of beta-cell function across a range of glucose tolerance from normal to diabetes. Diabetes, 48(9), 1779-1786. DOI: 10.2337/diabetes.48.9.1779   DOI
24 Q. Qiao & R. Nyamdorj. (2010). Is the association of type II diabetes with waist circumference or waist-to-hip ratio stronger than that with body mass index? European Journal of Clinical Nutrition, 64(1), 30-34. DOI: 10.1038/ejcn.2009.93   DOI
25 S. A. Chang et al. (2004). Body mass index is the most important determining factor for the degree of insulin resistance in non-obese type 2 diabetic patients in Korea. Metabolism, 53(2), 142-146. DOI: 10.1016/s0026-0495(03)00314-7   DOI
26 S. Funakoshi et al. (2008). Analysis of factors influencing pancreatic beta-cell function in Japanese patients with type 2 diabetes: association with body mass index and duration of diabetic exposure. Diabetes Research and Clinical Practice, 82(3), 353-358. DOI: 10.1016/j.diabres.2008.09.010   DOI
27 Y. Matsuzawa. (1997). Pathophysiology and molecular mechanisms of visceral fat syndrome: the Japanese experience. Diabetes/Metabolism Research and Reviews, 13(1), 3-13. DOI:10.1002/(sici)1099-0895(199703)13:1<3::aid-dmr178>3.0.co;2-n   DOI
28 A. E. Butler, J. Janson, S. Bonner-Weir, R. Ritzel, R. A. Rizza & P. C. Butler. (2003). Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes. Diabetes, 52(1), 102-110. DOI: 10.2337/diabetes.52.1.102   DOI
29 M. Sun et al. (2013). Characterization of $\beta$-cell function and insulin resistance in overweight Chinese adolescents with normal glucose tolerance. Experimental and Therapeutic Medicine, 6(2), 547-551. DOI: 10.3892/etm.2013.1164   DOI
30 S. Deng et al. (2004). Structural and functional abnormalities in the islets isolated from type 2 diabetic subjects. Diabetes, 53(3), 624-632. DOI: 10.2337/diabetes.53.3.624   DOI
31 D. R. Matthews, J. P. Hosker, A. S. Rudenski, B. A. Naylor, D. F. Treacher & R. C. Turner. (1985). Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia, 28(7), 412-419. DOI: 10.1007/BF00280883   DOI
32 B. G. Baez-Duarte et al. (2010). $\beta$-cell function is associated with metabolic syndrome in Mexican subjects. Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy, 3, 301-309. DOI: 10.2147/DMSOTT.S12375   DOI
33 L. X. Cubeddu & I. S. Hoffmann. (2012). Impact of traits of metabolic syndrome on $\beta$-cell function and insulin resistance in normal fasting, normal glucose tolerant subjects. Metabolic Syndrome and Related Disorders, 10(5), 344-350. DOI: 10.1089/met.2012.0040   DOI
34 M. Kasuga. (2006). Insulin resistance and pancreatic beta cell failure. Journal of Clinical Investigation, 116(7), 1756-1760. DOI: 10.1172/JCI29189   DOI
35 L. Mu, Y. Zhao, Y. Lai, R. Li & J. Qiao. (2018). Insulin resistance and $\beta$-cell dysfunction and the relationship with cardio-metabolic disorders among women with polycystic ovary syndrome. Clinical Endocrinology (Oxford), 89(6), 779-788. DOI: 10.1111/cen.13832   DOI
36 E Ferrannini. (1998). Insulin resistance versus insulin deficiency in non-insulin-dependent diabetes mellitus: problems and prospects. Endocrine Reviews, 19(4), 477-490. DOI: 10.1210/edrv.19.4.0336   DOI
37 J. O. Chung, D. H. Cho, D. J. Chung & M. Y. Chung. (2012). Associations among body mass index, insulin resistance, and pancreatic $\beta$-cell function in Korean patients with new-onset type 2 diabetes. Korean Journal of Internal Medicine, 27(1), 66-71. DOI: 10.3904/kjim.2012.27.1.66   DOI
38 M. G. Park et al. (2016). The relationship between body mass index and homeostasis model assessment index and the impact of vitamin D: based on 2010 Korean National Health and Nutrition Survey. Korean Journal of Family Practice, 6(5), 457-463. DOI: 10.21215/kjfp.2016.6.5.457   DOI
39 D. A. Garca-Estevez, D. Araujo-Vilar, A. Saavedra-Gonzalez, G. Fiestras-Janeiro & J. Cabezas-Cerrato. (2004). Analysis of the relationship between body mass index, insulin resistance, and beta-cell function: a cross-sectional study using the minimal model. Metabolism, 53(11), 1462-1466. DOI: 10.1016/j.metabol.2004.06.014   DOI
40 P. W. Wilson, R. B. D'Agostino, L. Sullivan, H. Parise & W. B. Kannel. (2002). Overweight and obesity as determinants of cardiovascular risk: the Framingham experience. Archives of internal medicine, 162(16), 1867-1872. DOI: 10.1001/archinte.162.16.1867   DOI