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http://dx.doi.org/10.15207/JKCS.2019.10.2.331

Treatment with ultra-dilutions of Arnica montana increases COX-2 expression and PGE2 secretion in mouse chondrocytes  

Kim, Yun Kyu (Department of Medicine, University of Ulsan College of Medicine)
Yeo, Myeong Gu (Department of Integrative Medical Sciences, Nambu University)
Publication Information
Journal of the Korea Convergence Society / v.10, no.2, 2019 , pp. 331-337 More about this Journal
Abstract
Objective: We studied the effects of 4x, 30x, 30c, and 200c homeopathic dilutions of A. montana on inflammation in primary cultured mouse chondrocytes. Methods: Examined expression of Coll-2 and COX-2, and secretion of PGE2. Results: Treatment with 4x, 30x, and 30c A. montana decreased mRNA expression of Coll-2 and 30x A. montana increased mRNA expression of COX-2, while treatment with 30x and 30c A. montana increased protein expression of COX-2. Treatment with the 30c A. montana increased release of PGE2. Conclusion: Treatment with A. montana induces dedifferentiation and inflammatory responses, including increased COX-2 expression and PGE2 secretion.
Keywords
Convergence; Arnica montana; Homeopathic medicine; COX-2; PGE2;
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Times Cited By KSCI : 2  (Citation Analysis)
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