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http://dx.doi.org/10.15207/JKCS.2018.9.8.225

Anti-fungal, anti-oxidant, and anti-inflammatory effects of supercritical fluid extracts from Ulmus davidiana  

Seo, Ju-Hee (Department of Cosmetology Science, Nambu University)
Lee, Yong-Jo (Department of Cosmetology Science, Nambu University)
Jo, Young-Ick (Nano Bio Research Center, JBF)
Ko, Jung-Yun (Nano Bio Research Center, JBF)
Mun, Myung-Jae (Nano Bio Research Center, JBF)
Park, Kwang-Hyun (Department of Oriental Pharmaceutical Development, Nambu University)
Choi, Sun Eun (Department of Cosmetology Science, Nambu University)
Publication Information
Journal of the Korea Convergence Society / v.9, no.8, 2018 , pp. 225-233 More about this Journal
Abstract
The Ulmus davidiana have been used in traditional oriental medicine as remedies for inflammation, ulcers, cancers, bacterial infections and scabies. In this study, the anti-fungal, anti-oxidant, and anti-inflammatory activitiesof a supercritical extract of U. davidiana were investigated in vitro. To explore the anti-oxidant and anti-inflammatory characteristics of the supercritical extract, ABTS radical scavenging activity, and the inhibition of nitric oxide production in LPS-stimulated RAW 264.7 cells were examined, respectively. In addition, the anti-fungal activities of the extract were assessed. The results showed a concentration-dependent increase in ABTS radical scavenging activity. Cells stimulated with LPS produced more nitric oxide than normal control cells; however, cells treated with the supercritical fluid extract decreased this production in a concentration-dependent manner. Finally, the supercritical fluid extracts showed significant anti-fungal activity. These results suggest that extracts of the U. davidiana might be used to develop potent anti-fungal, anti-oxidant, and anti-inflammatory agents, and may be useful as ingredients for related new functional cosmetic materials.
Keywords
Ulmus davidiana; supercritical fluid; anti-fungal; anti-oxidative; anti-inflammatory;
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