Browse > Article
http://dx.doi.org/10.15207/JKCS.2018.9.8.101

Effects of Barley Noodles Contained Mulberry Leave Extracts on Blood Glucose Regulation in Diabetic Mice  

Park, Chung-Mu (Dept. of Clinical Laboratory Science, Dong-Eui University)
Yoon, Hyun-Seo (Dept. of Dental Hygiene, Dong-Eui University)
Publication Information
Journal of the Korea Convergence Society / v.9, no.8, 2018 , pp. 101-108 More about this Journal
Abstract
This study aimed to investigate the blood glucose regulatory effect of barley noodles contained mulberry leaves water extract (MLWE) in diabetic mice in order to provide fundamental data as a functional food. ICR mice were divided into six groups as follows: normal control, positive control, barley control, mulberry control, barley+MLWE 2.5% and barley+MLWE 5% groups. High fat/high carbohydrate diet was fed for 4 weeks and diabetes mellitus was induced by i.p. injection of streptozotocin and nicotinamide. After diabetes induction, experimental diet was supplemented for 2 weeks and simultaneous measurement of body weight, blood glucose (including glucose tolerance test), liver function and blood lipid profile was conducted. As a result, there was less decrease in body weight compared to the positive control group in the groups that supplemented barley and MLWE together than the group ingesting barley and MLWE alone. In addition, regulatory effects on blood glucose, liver function and blood lipid concentration were also stronger in barley and MLWE concurrently supplemented groups. Consequently, combination of barley and MLWE was effective in the regulation of body weight, blood glucose, liver function, and blood lipid in diabetic mice. Therefore, this recipe could be a promising strategy for beneficial effects in the patients of diabetes mellitus.
Keywords
Diabetes Mellitus; Mulberry Leaves; Barley; Blood Glucose; Mixed formula;
Citations & Related Records
Times Cited By KSCI : 7  (Citation Analysis)
연도 인용수 순위
1 J.S. Lee. (2015). A Study on Application Service for Dietary Habit Improvement of Patients with Chronic Disease - Focused on Patients with Hypertension and Diabetes. Korea Society of Design Trend, 48, 71-82. DOI : 10.21326/ksdt.2015..48.006   DOI
2 J. H. Choi, J. H. Kang & H.M. Lee. (2014). Lifestyle, Diet, Self-care, and Diabetes Fatalism of Diabetic Patients with and without Diabetic Foot. Korean Society of Community Nutrition, 19(3), 241-249. DOI : 10.5720/kjcn.2014.19.3.241   DOI
3 J. H. Kang. (2005). Clinical Trial of Functional Food for Weight Control. Food industry and nutrition, 10(3), 1-4.
4 J. H. Ryu & J. O. Rho. (2013). Need for Development of a List of Meals for Diabetic Patients and Development of Barley-Based Diabetic Meals. Family and Environment Research, 51(5), 551-561. DOI : 10.6115/fer.2013.51.5.551   DOI
5 H. K. Son, Y. M. Lee, Y. H. Park & J. J. Lee. (2016). Effect of Young Barley Leaf Powder on Glucose Control in the Diabetic Rats. Korean Society of Community Living Science, 27(1), 19-29. DOI : 10.7856/kjcls.2016.27.1.19   DOI
6 Angeli JP, Ribeiro LR, Angeli JL, Mantovani MS. (2009). Protective effects of b-glucan extracted from barley against benzo[a]pyrene-induced DNA damage in hepatic cell HepG2. Exp Toxicol Pathol, 61(1), 83-89. DOI : 10.1016/j.etp.2008.05.003   DOI
7 Y. S. Yoo, K. S. Lee, K.H. Cho, Kim, C.H. Park, S.H. Lee, J.H. Lee & D.H. Kim. (2009). Effect of barley on variation of blood glucose and lipid metabolism. Korean J. of Family Medicine, 30(10), 790-795. DOI : 10.4082/kjfm.2009.30.10.790   DOI
8 O.G. Kim, J.C. Jeong. (2006). Effects of the Mori folium Extract in Streptozotocin-Induced Diabetic Rats. Korean J. Orient. Int. Med. 27(4), 811-821.
9 Shimizu R, Sakazaki F, Okuno T, Nakamuro K, Ueno H. (2012). Difference in glucose intolerance between C57BL/6J and ICR strain mice with streptozotocin/nicotinamide-induced diabetes.. Biomedical Research, 33(1), 63-66. DOI : 10.2220/biomedres.33.63   DOI
10 Hunyadi A, Veres K, Danko B, Kele Z, Weber E, Hetenyi A, Zupko I, Hsieh TJ. (2013). In vitro anti-diabetic activity and chemical characterization of an apolar fraction of Morus alba leaf water extract. Phytother. Res., 27(6), 847-851. DOI : 10.1002/ptr.4803   DOI
11 E.H. Jang. (2017). Quality of Life Factors and Comparative Analysis in Workers with Diabetes Mellitus in terms of Convergence : using the Korean National Health and Nutrition Examination Survey, 2007-2015. J of the Korea Convergence Society, 8(12), 167-178. DOI : 10.15207/JKCS.2017.8.12.167   DOI
12 M. Y. Shon, S. Y. Choi, H. S. Cho, N. J. Sung. (2004). Effects of Cereal and Red Ginseng Flour on Blood Glucose and Lipid Level in Streptozotocin - Induced Diabetic Rats. J. Korean Society of Food Science and Nutrition, 33(9), 1463-1468. DOI : 10.3746/jkfn.2004.33.9.1463   DOI
13 E.O. Choi, D.H. Kwon, M.Y. Kim, H. Hwang-Bo, H.J. Kim, K.I. Ahn, J.W. Jeong, K.W. Lee, K.Y. Kim, S.G. Kim, Y.W. Choi, S.H. Hong, C. Park, Y.H. Choi. (2016). Single Dose Oral Toxicity Test of Ethanol Extracts of Schisandrae fructus and Mori folium, and their Mixture in ICR Mice. J. Life Science, 26(10), 1207-1213. DOI : 10.5352/JLS.2016.26.10.1207   DOI
14 K. M. Yang, S. R. Shin & J. H. Jang. (2006). Effect of Combined Extract of Safflower Seed with Herbs on Blood Glucose Level and Biochemical Parameters in Streptozotocin - induced Diabetic Rats. J. Korean Society of Food Science and Nutrition, 35(2), 150-157. DOI : 10.3746/jkfn.2006.35.2.150   DOI
15 KUSMIATI, F.X.R. DHEWANTARA. (2016). Cholesterol-Lowering Effect of Beta Glucan Extracted from Saccharomyces cerevisiae in Rats. Sci Pharm, 84(1), 153-166. DOI : 10.3797/scipharm.ISP.2015.07   DOI
16 P. Sharma, H.S. Gujral. (2010). Antioxidant and polyphenol oxidase activity of germinated barley and its milling fractions. Food Chemistry, 120(3), 673-678. DOI : 10.1016/j.foodchem.2009.10.059   DOI
17 Final Comprehensive Global Monitoring Framework for NCDs [Internet]. WHO: [cited 2017 Feb 10]. Available from : https://www.idf.org/sites/default/files/GMF_Final%20Table%20of%20Targets.pdf.).
18 S. K. Jang & J. S. Lee. (2017). Prevalence and Management of Dyslipidemia, Hypertension, Diabetes Among Adults in Gangwon-do, Korea: the 2013-2014 KNHSP. J of the Korea Academia-Industrial, 18(3), 625-636. DOI : 10.5762/KAIS.2017.18.1.625   DOI
19 Diabetes Fact Sheet in Korea 2018. (2018). Korean Diabetes Association, pp.1-40.
20 D.J. Kim. (2011). The Epidemiology of Diabetes in Korea. Diabetes Metab J. 35(4), 303-308. DOI : 10.4093/dmj.2011.35.4.303   DOI
21 H.S. Kim. (2003). A Survey of Blood Glucose Testing, Medication, Diet, and Exercise Adherence in Korean Patients with Type2 Diabetes. J of Fundamentals of Nursing, 10(2), 181-186.
22 J. N. Yoo, G .J. Yoo & B. K. Yoo. (2005). Exenatide: a New Agent for the Treatment of type 2 Diabetes Mellitus as Adjunctive Therapy. Kor. J. Clin. Pharm., 15(2), 165-172.