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http://dx.doi.org/10.11625/KJOA.2019.27.4.513

Anti-oxidant and Anti-inflammatory Effects of Ethanol Extracts from Aerial Part of Coriandrum sativum L.  

Nan, Li (전북대학교 농업생명과학대학 작물생명과학과)
Lee, Chang-Hyun (전북대학교 농업생명과학대학 작물생명과학과)
Choi, You-Na (전북대학교 농업생명과학대학 작물생명과학과)
Choo, Byung-Kil (전북대학교 농업생명과학대학 작물생명과학과)
Publication Information
Korean Journal of Organic Agriculture / v.27, no.4, 2019 , pp. 513-528 More about this Journal
Abstract
Coriandrum sativum L., an annual herbaceous plant of Apiaceae family. The present study evaluated the anti-oxidant activities and anti-inflammatory effects of ethanol extracts of C. sativum. The anti-oxidant activities of C. sativum were measured by total contents of polyphenol, flavonoid, DPPH and ABTS radical scavenging and reducing power activity. And anti-inflammatory effects of C. sativum were measured by LPS-induced RAW 264.7 cells. The results showed that the contents of total polyphenol and flavonoid were 76.03 ± 1.36 mg of gallic acid equivalents/g and 182.23 ± 4.32 mg of rutin equivalents/g at concentration 1 mg/mL of C. sativum. The DPPH radical scavenging activity was found to be 52.8% at 500 ㎍/mL. The ABTS radical scavenging activity was shown in 58.3% after exposure to 1,000 ㎍/mL. Reducing power activity was found to be 66.8% at 2,000 ㎍/mL. The inhibitory effect of NO production was found to be 65% concentration 500 ㎍/mL. In the generation quantity of inflammatory cytokines such as TNF-α and IL-1β in cell culture medium, the expression levels of inflammatory proteins in cells were showed decrease with the increase of concentration. Therefore, we suggest that the C. sativum should be a potential source of alternative anti-inflammatory drug with good anti-inflammatory effects.
Keywords
anti-inflammation; antioxidant; cytokine; coriandrum sativum; $NF-{\kappa}B$ signaling pathway;
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