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Anti-allergic effects of So-Cheong-Ryong-Tang in ovalbumin-induced allergic rhinitis model  

Kim, Ilhwan (Department of Preventive Medicine, College of Korean Medicine, Kyunghee University)
Ku, Jinmo (Department of Preventive Medicine, College of Korean Medicine, Kyunghee University)
Hur, Hansol (Department of Preventive Medicine, College of Korean Medicine, Kyunghee University)
Na, Changhyeok (Department of Preventive Medicine, College of Korean Medicine, Kyunghee University)
Jang, Bo-Hyoung (Department of Preventive Medicine, College of Korean Medicine, Kyunghee University)
Shin, Yong-Cheol (Department of Preventive Medicine, College of Korean Medicine, Kyunghee University)
Ko, Seong-Gyu (Department of Preventive Medicine, College of Korean Medicine, Kyunghee University)
Publication Information
Journal of Society of Preventive Korean Medicine / v.18, no.3, 2014 , pp. 69-80 More about this Journal
Abstract
Objective : Allergic rhinitis (AR) is an allergic inflammation of the nasal airways. Socheongryong-Tang traditionally has been used in Korea for treatment of allergy diseases. In the present study, we investigated whether SCRT suppresses the progression of AR in vivo and in vitro. Method : In this study, we investigated the effect of oral administration of SCRT on the Ovalbumin(OVA)-induced allergic rhinitis mouse models. Additionally, to find a possible explanation for the anti-inflammation effects of SCRT, we evaluated the inflammatory cytokine levels in LPS-stimulated mouse inflammation cell (RAW264.7) and mouse splenocyte. Results : The finding of this study demonstrated that SCRT reduced mast cells and inflammation cells infiltration in OVA-induced nasal cavity. Additionally, SCRT inhibited the production of inflammatory cytokines in splenocyte. However SCRT don't inhibited the production of inflammatory cytokines in RAW264.7 cells. Conclusion : Taken together, our results showed that oral administration of SCRT beneficial effects in allergic rhinitis, suggesting that SCRT might be a useful candidate for the treatment of allergic rhinitis.
Keywords
allergic rhinitis; inflammation; ovalbumin; mast cells; RAW264.7 cells; Socheongryong-Tang;
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