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A Case Study on Drug Prescription for Vascular Dementia in Western and Oriental Medicine  

Choi, Seong-Hun (Department of Anatomy and Histology, College of Oriental Medicine, Daeggu Haany University)
Cheon, Woo-Hyun (Department of Neurology, College of Oriental Medicine, Daeggu Haany University)
Baek, Kyung-Min (Department of Internal Medicine, College of Oriental Medicine, Daeggu Haany University)
Han, Chang-Hyun (TKM Information Research Division, Korea Institute of Oriental Medicine)
Jeon, Won-Kyung (Center for Herbal Medicine Improvement Research, Korea Institute of Oriental Medicine)
Gam, Cheol-Ou (Department of Internal Medicine, College of Oriental Medicine, Dong Eui University)
Lee, Young-Joon (Department of Preventive Medicine, College of Oriental Medicine, Daeggu Haany University)
Publication Information
Journal of Society of Preventive Korean Medicine / v.15, no.3, 2011 , pp. 39-49 More about this Journal
Abstract
Objectives : Vascular dementia is the second common cause of dementia after Alzheimer's disease. It assumed that the ratio of prescription drugs on vascular dementia are quite different from each hospital in Western medicine or Oriental medicine, respectively. The aim of this research is to collect and analyze the ratio of prescription drugs on vascular dementia in Western medicine or Oriental medicine in university hospitals. Methods : We collected and analyzed the data related to prescriptions on vascular dementia in the department of neurology in three university hospitals(A, B, C) and in the department of internal medicine in two Oriental medicine hospitals(Daegu Haany Oriental Hospital, Dong Eui Oriental Hospital). Results : In the department of neurology in A university hospital, donepezil(69.1%), memantine(14.0%), rivastigmine(12.3%), galantamine(4.5%) were prescribed in order. In B university hospital, galantamine(57.8%) donepezil(33.3%), rivastigmine(6.7%), donepezil with memantine(4.4%) were prescribed. In C university hospital, donepezil(62.0%), rivastigmine(25.0%), galantamine(7.0%) memantine(6.0%) were prescribed. The average frequencies of prescribed medication in the department of neurology in A, B, C university hospitals were donepezil(54.8%), galantamine(23.1%), rivastigmine(14.7%), memantine(7.4%). In Oriental medicine hospitals, various prescriptions have been used for vascular dementia. Among them, Ansincheongnoetang (安神淸腦湯) and Gamijihangeumja(加味地黃飮子) were often prescribed in Daegu Haany Oriental Hospital, and Bojungikgitang(補中益氣湯) in Dong Eui Oriental Hospital, too. Conclusions : Cholinesterase inhibitors such as donepezil, galantamine, rivastigmine and NMDA receptor inhibitor like memantine have been used as a drug of choice for vascular dementia in all surveyed university hospitals. In oriental hospitals, various prescriptions have been used for vascular dementia.
Keywords
Vascular dementia; Cholinesterase inhibitor; Prescription; Memantine;
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Times Cited By KSCI : 1  (Citation Analysis)
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1 Roman GC. Vascular dementia : distinguishing characteristics, treatment and prevention. J Am Geriatr Soc. 2003 ; 51 : 296-304.   DOI   ScienceOn
2 대한치매학회. 치매 임상적 접근. 서울 ; 아카데미아. 2006 : 413-425.
3 최성훈, 구세광, 전우현, 백경민, 한창현, 전원경, 이영준. 피질하 혈관성치매의 진단, 치료 및 예방 : 1례 보고와 함께. 대한예방한의학회지. 2010 ; 14(3) : 63-75.
4 Rockwood K. Vascular cognitive impairment and vascular dementia. J Neurol Sci. 2002 ; 203-204 : 23-7.
5 Vinters HV, Ellis WG, Zarow C, Zaias BW, Jagust WJ, Mack WJ, et al. Neuropathologic substrates of ischemic vascular dementia. J Neuropathol Exp Neurol. 2000 ; 60 : 658-659.
6 김상찬, 김선희, 노승현, 박선동, 변성희, 서부일, 서영배, 외. 방제학. 서울: 영림사. 1999 : 462-464.
7 조맹제. 국내 치매 노인 유병률 현황과 위험요인. 보건복지포럼. 2009 ; 156 : 43-48.
8 Orgogozo JM, Rigaud AS, Stoffler A, Mobius HJ, Forette F. Efficacy and safety of memantine in patients with mild to moderate vascular dementia : a randomized, placebo-controlled trial(MMM 300). Stroke. 2002 ; 33 : 1834-1839.   DOI   ScienceOn
9 대전대학교 한방병원처방집. 대전 : 한국출판사. 1997 : 118.
10 이상룡, 김보경. 安神淸腦湯이 알츠하이머질환 병태 모델의 생화학적 변화 및 기억에 미치는 영향. 동의생리병리학회지. 2001 ; 15(5) : 708-722.
11 최인선, 민성순, 김종환, 서상호, 박상은, 김영균, 권정남. 補中益氣湯 및 그 加味方을 투여한 중풍환자에 대한 임상적 고찰. 대한한방내과학회지. 2004 ; 25(3) : 388-397.
12 Onor ML, Trevisiol M, Aguglia E. Rivastigmine in the treatment of Alzheimer's disease : an update. Clin Interv Aging. 2007 ; 2(1) : 17-32.   DOI   ScienceOn
13 Roman GC, Wilkinson DG, Doody RS, Black SE, Salloway SP, Schindler RJ. Donepezil in vascular dementia : combined analysis of two large-scale clinical trials. Dement Geriatr Cogn Disord. 2005 ; 20(6) : 338-44.   DOI   ScienceOn
14 Black S, Roman GC, Geldmacher DS, Salloway S, Hecker J, Burns A, Perdomo C, Kumar D, Pratt R ; Donepezil 307 Vascular Dementia Study Group. Efficacy and tolerability of donepezil in vascular dementia : positive results of a 24-week, multicenter, international, randomized, placebo-controlled clinical trial. Stroke. 2003 ; 34 (10) : 2323-30.   DOI   ScienceOn
15 Heinrich M, Lee TH. Galanthamine from snowdrop-the development of a modern drug against Alzheimer's disease from local Caucasian knowledge. J Ethnopharmacol. 2004 ; 92(2-3) : 147-62.   DOI
16 Santos MD, Alkondon M, Pereira EF et al. The nicotinic allosteric potentiating ligand galantamine facilitates synaptic transmission in the mammalian central nervous system. Mol Pharmacol. 2002 ; 61 : 1222-1234.   DOI   ScienceOn
17 Erkinjuntti T, Kurz A, Gauthier S et al. Efficacy of galantamine in probable vascular dementia and Alzheimer's disease combined with cerebrovascular disease : A randomised trial. Lancet 2002 ; 359 : 1283-1290.   DOI   ScienceOn
18 Moretti R, Torre P, Antonello RM et al. Rivastigmine in subcortical vascular dementia : An open 22-month study. J Neurol Sci 2002 ; 203-204 : 141-146.
19 Lancelot E, Beal MF. Glutamate toxicity in chronic neurodegenerative disease. Prog Brain Res. 1998 ; 116 : 331-347.