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The Toxicokinetic Characteristics of Korean Traditional Medicines  

Park, Yeong-Chul (GLP Center, Catholic University of Daegu)
Shin, Heon-Tae (Dept. of Preventive Medicine, Dongshin University, College of Oriental Medicine)
Lee, Sun-Dong (Dept. of Preventive medicine, School of Oriental Medicine, Sangji University)
Publication Information
Journal of Society of Preventive Korean Medicine / v.15, no.2, 2011 , pp. 1-19 More about this Journal
Abstract
Toxicokinetics of Korean Traditional Medicines(TKM) is the description of what rate TKM will enter the body and what happens to it once it is in the body in terms of toxicology. However, it is not easy to understand TKM toxicokinetics because of various factors such as a mixture of 2-30 kinds of herbal materials containing thousands of chemicals, and complex chemical properties. For these reasons, little is known about toxicokinetics of TKM. This study was aimed to characterize and review the absorption, distribution and metabolism of korean traditional medicines in a view of toxicokinetics. For this aim, some of korean traditional medicines were reviewed on a basis of drug-drug interaction, biotransformation and intestinal metabolisms by bacteria. As the factors affecting mainly on toxicokinetics of TKM, individual herbal material's degree of lipophilicity and metabolic rate, and decoction components according to different kinds of herbal materials were considered. Other factors such as intestinal pH and bacterial activity for metabolism affecting on TKM toxicokinetics, especially in small intestine. It would be a better way for improving the adverse or poor effects caused by TCM if the factors affecting on toxicokinetics of TKM is considered.
Keywords
Korean traditional medicines; toxicokinetics; intestinal metabolism; biotransformation;
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