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What is Epigenetics? -Focusing on Basic Concepts and Mechanisms-  

Lee, Sun-Dong (Sangji University, College of Oriental Medicine, Department of Preventive Medicine)
Park, Sung-Kyun (University of Michigan, School of Public Health Environmental Health Sciences)
Ko, Seong-Gyu (Kyung Hee University, College of Oriental Medicine, Department of Preventive Medicine)
Shin, Heon-Tae (Dongshin University, College of Oriental Medicine, Department of Preventive Medicine)
Kim, Myung-Dong (Sangji University, College of Oriental Medicine, Department of Oriental Physiology Medicine)
Publication Information
Journal of Society of Preventive Korean Medicine / v.14, no.2, 2010 , pp. 1-12 More about this Journal
Abstract
The individual differences in disease development and susceptibility have been researched primarily on the subject of genes, environment or the interaction between genes and the environment respectively. However, there have been limitations in explaining complex diseases, and the differences in health and diseases in monozygotic and dizygotic twins. Fortunately, thanks to active research on the relationship between genes and the environment, and epigenetics, there has been much progress in the understanding of body's reactions and changes. Epigenetics is referred to as a study of gene expression through the interactions of DNA methylation, chromatin's histone and the change of structure in tail, RNA editing without any change in DNA sequence. In this paper, we introduce the basic concepts and mechanisms of epigenetics. The result of the epigenetics is heritable ; can regulate gene expressions ; is reversible ; and has many variable forms depending on cell types. The influences of epigenetics occur throughout life, but it is mainly determined in utero during early pregnancies. Diseases occur or the risk rises if these influences continue after birth until adult life when problems occur in excess/lack of nutrition, environmental plasticity, or already inputted data. Therefore, there is a need for change and innovation, especially in interest and investment in health education for young women near pregnancies and correct treatment of epigenetic-related diseases.
Keywords
epigenetics; gene expression and modification; gene; environment; DNA methylation;
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1 Lopez J, Percharde M, Coley HM, Webb A, Crook T. The context and potential of epigenetics in oncology. British Journal of Cancer 2009 ; 100 : 571-577.   DOI   ScienceOn
2 Cardno, A.G. and Gottesman, I.I., II. Twin studies of schizophrenia : From bow-andarrow concordances to Star Wars Mx and functional genomics. Am. J. Med. Genet 2000 ; 97 : 12-17.   DOI   ScienceOn
3 Fish E, Shahrokh D, Bagot R, Caldji C, Bredy T, Szyf M, Meaney M. Epigenetic Programming of Stress through Variations in Maternal Care. Ann. N.Y. Acade. Sci. 2004 ; 1036 : 167-180.
4 Szyf M, Weaver I, Meaney M. Maternal care, the epigenome and phenotype differences in behavior. Reproductive Toxicology 2007 ; 24 : 9-19.   DOI   ScienceOn
5 Fraga M, Esteller M. Epgienetics and aging: the targets and the marks. TRENDS in Genetics 2007 ; 23(8) : 413-418.   DOI   ScienceOn
6 Steinhardt, G. F. Endocrine disruption and hypospadias. Adv. Exp. Med. Biol 2004 ; 545 : 203-215   DOI
7 Zeisel S. Epigenetic mechanisms for nutrition determinants of later health outcomes. Am J Clin Nutr 2009 ; 89(suppl) : 1S-6S.   DOI
8 Langley-Evans S. Nutritional programming of disase : unraveling the mechanism. J. Anat. 2008 ; 1-16.
9 Merico V, Barbieri J, Zuccotti M, Joffe B, Cremer T, Redi CA, Solovei I, Garagna S. Epigenomic differentiation in mouse preimplantation nuclei of biparental, parthenote and cloned embryos. Chromosome Research 2007 ; 15 : 341-360.
10 Fujii, T. Transgenerational effects of maternal exposure to chemicals on the functional development of the brain in the offspring. Cancer Causes Control 1997 ; 8 : 524-528.   DOI   ScienceOn
11 Csaba, G. & Karabelyos, C. Transgenerational effect of a single neonatal benzpyrene treatment (imprinting) on the sexual behavior of adult female rats. Hum. Exp. Toxicol 1997 ; 16 : 553-556.   DOI   ScienceOn
12 Santos F, Hendrich B, Reik W, Dean W. Dynamic Reprogramming of DNA Methylation in the Early Mouse Embryo. Developmental Biology 2002 ; 241 : 172-182.   DOI   ScienceOn
13 Burdge G, Hanson M, Slater-Jefferies J, Lillycrop K. Epigenetic regulation of transcription :A mechanism for inducing variations in phenotype(fetal programming) by differences in nutrition during early life? Br J Nutr 2007 ; 97(6) : 1036-1046.   DOI   ScienceOn
14 Michael K. Skinner, Mohan Manikkam and Carlos Guettero-Bosagna. Epigenetic transgenerationalactions of environmenral factors in disease etiology. Trends in Endocrinology and Metabolism Vol.21 No.4 : 214-220.
15 Zeisel S. Epigenetic mechanisms for nutrition determinants of later health outcomes. Am J Clin Nutr 2009 ; 89(suppl) : 1S-6S.   DOI
16 Langley-Evans S. Nutritional programming of disase: unraveling the mechanism. J. Anat. 2008 ; 1-16.
17 Roseboom TJ, van der Meulen JH, Ravelli AC, Osmond C, Barker DJ, Bleker OP. Effects of prenatal exposure to the Dutch famine on adult disease in later life : an overview. Twin Research 2001 ; 4 : 293-298.   DOI
18 Sergio E Baranzini, Joann Mudge, Jeniifer C. van Velkinburgh, Pouya Khankhanian, Irina Khrebtukova, Neil A. Miller, etc. Genome, epigenome and RNA sequences of monozygotic twins discordant for multiple sclerosis. Nature 2010 ; 464(29) : 1351-1358.   DOI   ScienceOn
19 Cess B. M. Oudejans. Noncoding RNA and DNA as biomarkers : Toward an EpigeneticFetal Barcode for Use in Maternal Plasma. Clinical Chemistry 2008 ; 54(3) : 456-457.   DOI   ScienceOn
20 Sarah Tucker, Alexa Vitins and Craig S Pikaard. Nucleolar dominance and ribosomal RNA gene silencing. Current Opinion in Cell Biology 2010 ; 22 : 351-356.   DOI   ScienceOn
21 Allison L. 대표역자 최원재. 분자생물학입 문서. 월드사이언스 2009, p.13, 14, 18-25, 38-43, 120, 134-5, 313-323, 351-356, 393-426.
22 Nafee TM, Farrell WE, Carroll WD, Fryer AA, Ismail KMK. Epigenetic control of fetal gene expression. BJOG 2008 ; 115 : 158-168.
23 박성균, 이선동. 환경오염물질과 에피제네틱. 한국환경보건학회지. 2009 ; 35(5) : 343-354.   과학기술학회마을
24 Cooper C, Fall C, Egger P, Hobbs R, Eastell R, Barker D. Growth in infancy andbone mass in later life. Ann Rheum Dis 1997 ; 56 : 17-21.
25 Frankel S, Elwood P, Sweetnam P, Yarnell J, Smith GD. Birthweight, body-mass index in middle age, and incident coronary heart disease. Lancet 1996 ; 348 : 1478-80.   DOI   ScienceOn
26 Waterland R, Michels K. Epigenetic Epidemiology of the Developmental Origins Hypothesis. Metab Disord 2007 ; 27 : 363-88.
27 Stanner SA, Yudkin JS. Fetal programming and the Leningrad Siege study. Twin Research 2001 ; 4 : 287-292.   DOI   ScienceOn
28 Bolin C, Basha R, Cox D, Zawia N, Maloney B, Lahiri D, Cardozo-Pelaez F. Exposure to lead (Pb) and the developmental origin of oxidative DNA damage in the aging brain. The FASEB Journal 2006:1-19.
29 Steinke JW, Rich SS, Borish L. 5. Genetics of allergic disease. J Allergy Clin Immunol. 2008 ; 121(2 suppl) : S384-S387quiz S416.   DOI
30 Lucas A. Programming by early nutrition in man. Ciba Foundation Symposium 1991 ; 156 : 38-50.
31 Rich-Edwards JW, Stampfer MJ, Manson JE, et al. Birth weight and risk of cardiovascular disease in a cohort of women followed up since 1976. BMJ 1997 ; 315 : 396-400.
32 Schanen NC. Epigenetics of autism spectrum disorders. Hum Mol Genet. 2006 ; 15(specno 2) : R138-R150.   DOI
33 Campion J, Milagro F., Martinez J. Individuality and epigenetics in obesity. Obesity Reviews 2009 : 1-10.
34 Poulsen P, Esteller M, Vaag A, Fraga M. The Epigenetic Basis of Twin Discordance in Age-Related Diseases. Pediatric Research 2006 ; 61(5) : 38R-42R.
35 Qiu J. Unfinished Symphony. Nature 2006 (news feature) ; 441 : 143-145.   DOI   ScienceOn
36 Wu J, Basha R, Brock B, Cox D, Cardozo- Pelaez F, McPherson C, Harry J, Rice D, Maloney B, Chen D, Lahiri D, Zawia N. Alzheimer's Disease (AD)-Like Pathology in Aged Monkeys after Infantile Exposure to Environmental Metal Lead (Pb) : Evidence for a Developmental Origin and Environmental Link for AD. The Journal of Neuroscience 2008 ; 28(1) : 3-9.   DOI   ScienceOn
37 Esteller M. Epigenetics in Cancer. The New England Journal of Medicine 2008 ; 358 : 1148-59.   DOI   ScienceOn
38 Francis N, Kingston R, Woodcock C. Chromatin Compaction by a Polycomb Group Protein Complex. Science 2004 ; 306 : 1574-1577.   DOI
39 Mutskov V, Raaka BM, Relsenfeld G, Gershengorn MC. The human insulin gene displays transcriptionally active epigenetic marks in islet-derived mesenchymal precursor cells in the absence of insulin expression. Stem Cells 2007 ; 25 : 3223-3233.   DOI   ScienceOn
40 Ling C, Del Guerra S, Lupi R, Rönn T, Gronhall C, Luthman H, Masiello P, Marchetti P, Groop L, Del Prato S. Epigenetic regulation of PPARGC1A in human type 2 diabetic islets and effect on insulin secretion. Diabetologia(2008) 51 : 615-622.   DOI   ScienceOn
41 Petronis A. Epigenetics and twins : three variations on the theme. TRENDS in Genetics 2006 ; 22(7) : 347-350.   DOI   ScienceOn
42 Davis C, Uthus E. DNA Methylation, Cancer Susceptibility, and Nutrient Interactions. The Society for Experimental Biology and Medicine 2004 ; 229 : 988-995.   DOI
43 Tang WY, Ho SM. Epigenetic reprogramming and imprinting in origins of disease. Rev Endocr Metab Disord 2007 ; 8 : 173-182.   DOI   ScienceOn
44 Morange M. The Relations between Genetics and Epigenetics. Ann. N.Y. Acad. Sci. 2002 ; 981 : 50-60. Gosden R, Feinberg A. Genetics and Epigenetics–Nature's Penand- Pencil Set. N Engl J Med 2007 ; 356 :731-733.   DOI   ScienceOn
45 Wong A, Gottesman I, Petronis A. Phenotypic differences in genetically identical organisms : the epigenetic perspective. Human Molecular Genetics 2005 ; 14 : R11-R18.   DOI   ScienceOn
46 Gluckman P, Hanson M, Beedle A. Early Life Events and Their Consequences for Later Disease : A Life History and Evolutionary Perspective. American Journal of Human Biology 2007 ; 19 : 1-19.   DOI   ScienceOn
47 Nakao M. Epigenetics : interaction of DNA methylation and chromatin. Gene 2001 ; 278 : 25-31.   DOI
48 Geiman TM, Robertson KD. Chromatin Remodeling, Histone Modifications, and DNA Methylation–How Does it All Fit Together? Journal of Cellular Biochemistry 2002 ; 87 : 117-125.   DOI   ScienceOn
49 Lichtenstein P, Holm N, Verkasalo P, Iliadou A, Kaprio J, Koskenvuo M, Pukkala E, Skytthe A, Hemminki K. Environmental and Heritable Factors in the Causation of Cancer. The England Journal of Medicine 2000 ; 343(3) : 78-85.   DOI
50 Fraga M, Ballestar E, Paz M, Ropero S, Setien F, Ballestar M, Heine-Suner, Cigudosa J, Urioste M, Benitez J, Boix-Chornet M, Sanchez-Aguilera A, Ling C, Carlsson E, Poulsen P, Vaag A, Stephan Z, Spector T, Wu YZ, Plass C, Esteller M. Epigenetic differences arise during the life of monozygotic twins. PNAS 2005 ; 102(30) : 10604-10609.   DOI   ScienceOn
51 Youngson N, Whitelaw E. Transgenerational Epigenetic Effects. Annu. Rev. Genom. Human Genet. 2008 ; 9 : 233-57.   DOI   ScienceOn
52 Anway M, Skinner M. Epigenetic Transgenerational Actions of Endocrine Disruptors. Endocrinology 2006 ; 147(6)(Supplement) : S43-S49.   DOI
53 Ozanne S, Constancia M. Mechanisms of Disease : the developmental origins of disase and the role of the epigenotype. Nature Clinical Practice 2007 ; 3(7) : 539-546.   DOI   ScienceOn
54 Waterland R, Jirtle R. Transposable Elements :Targets for Early Nutritional Effects on Epigenetic Gene Regulation. Molecular and Cellular Biology 2003 ; 23(15) : 5293-5300.   DOI   ScienceOn
55 Dolinoy D, Huang D, Jirtle R. Maternal nutrient supplementation counteracts bisphenol A-induced DNA hypomethylation in early development. PNAS 2007 ; 104 (32) : 13056-13061.   DOI   ScienceOn
56 Weaver I, Cervoni N, Champagne F, Alessio A, Sharma S, Seckl J, Dymov S, Szyf M, Meaney M. Epigenetic programming by maternal behavior. Nature Neuroscience 2004 ; 7(8) : 847-854.   DOI   ScienceOn
57 Martin C, Zhang Yi. Mechanisms of epigenetic inheritance. Current Opinion in Cell Biology 2007 ; 19 : 266-272.   DOI   ScienceOn
58 Waterland R. Is Epigenetics an Important Link between Early Life Events and Adult Disease? Horm Res 2009 ; 71(suppl 1) : 13-16.
59 Jirtle R, Skinner M. Environmental epigenomics and disase susceptibility. Nature 2007 ; 8 : 253-262.
60 Bertelsen A, Harvald B, Hauge M. A Danish twin study of manic-depressive disorders. Br J Psychiatry 1977 ; 130 : 330-51.   DOI   ScienceOn
61 Wu G, Bazer F, Cudd T, Meininger C, Spencer T. Maternal Nutrition and Fetal Development. The Journal of Nutrition 2004 : 2169-2172.
62 Gluckman P, Hanson M, Cooper C, Thornburg K. Effect of In Utero and Early-Life Conditions on Adult Health and Disease. N Engl J Med 2008 ; 359 : 61-73.   DOI   ScienceOn
63 Waggoner D. Mechanisms of Disease : Epigenesis. Seminars in Pediatric Neurology 2007:7-14.
64 Foley D, Craig J, Morley R, Olsson C, Dwyer T, Smith K, Saffery R. Prospects for Epigenetic Epidemiology. Am J Epidemiol 2009 ; 169 : 389-400.
65 Delcuve G, Rastegar M, Davie J. Epigenetic Control. J. Cell. Physiol 2009 : 243-250.