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Diversity and its Characteristics of Life Phenomenon  

Lee, Sun-Dong (Department of Preventive Medicine, College of Oriental Medicine, Sangji University)
Publication Information
Journal of Society of Preventive Korean Medicine / v.14, no.1, 2010 , pp. 1-12 More about this Journal
Abstract
This research was intended to delve into the diversity of life phenomenon and its characteristics. First of all, this research gave real examples to compare the differences in men's health, disease, and longevity in order to confirm the existence of diversity of life phenomenon. In addition, it also studied the process and mechanism of manifestation of life phenomenon, as well as the influence and problems of existing studies' results and implications. The results are as follow. 1. Differences in health, diseases, and longevity were very big and diverse in researches on different races, nations, ages, socioeconomic status, positions, and even (monozygotic) twins. 2. The basic foundation of all organisms is DNA, and environmental factors change DNA methylation and the structure of chromatin by constantly influencing DNA. Due to this, the manifestation, control, and phenotype of DNA change, resulting in diversified life phenomenon. Therefore, it is the environmental factors, not DNA, that has more influence on the diversity of life. 3. Looking at available studies, the most reasonable perspective on human requires focusing on the diversity of life phenomenon, holistic thinking, and reversible change instead of irreversible determinism. Considerable differences in life phenomenon between entities require a change in malformed perspective on life. Public health and medicine deals with live human beings, a more precise and accurate perspective on life is very important. Because management methods of health and disease, such as structure and approaches of medical research, prevention and cure, must be different by life perspectives.
Keywords
Life phenomenon; Diversity; Characteristics; Epigenetics;
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1 최찬헌, 윤대환, 임진석, 백진웅, 사상체질 불변론에 대한 이론적 검토. 대한예방한의학회지, 2008 ; 12(2) : 115-130   과학기술학회마을
2 이제마, 동의수세보원. 을유문화사, 2002
3 Gluckman PD, Hanson MA, Living with the past ; Evolution, development, and pattern of disease. Science, 2004 ; 305(17) : 1734-36
4 Federoff HJ, Gostin LO, Evolving from reductionism to holism. JAMA, 2009 ; 302(9) : 994-996   DOI   ScienceOn
5 Desiere F, Towards a systems biology understanding of human health ; interplay between genotype, environmental and nutrition. Biotechnol Annu Rev, 2004 ; 10 : 51-84   DOI
6 Toscano WA, Oehike KP, Systems biology : New approaches to old environmental health problems. Int J Environ Res public Health, 2005 ; 2(1) : 4-9   DOI
7 Robinson GE, Beyond nature and nurture. Science, 2004 ; 304 : 397-399   DOI
8 Solidini M, The clinical medicine : Is it science or art? Some epidemiological consideration on medicine. Med Secoli, 2004 ; 16(10) : 133-56
9 Waterland R, Jirtle R. Transposable elements : Targets for early nutritional effects on epigenetic gene regulation. Molecular and Cellular Biology, 2003 ; 23(15) : 5293-5300   DOI   ScienceOn
10 Dolinoy DC, Jirtle R. Environmental epigenetics in human health and disease. Environmental and Molecular Mutagenesis, 2008 ; 49 : 4-8   DOI   ScienceOn
11 박성균, 이선동. 환경오염물질과 에피제네틱스. 환경보건학회지 2009 ; 35(5) : 343-354
12 Jaenisch R, Bird A, Epigenetic regulation of gene expression how the genome integrates intrinsic and environmental signals. Nature Genetics Supplement, 2003 ; 33 : 245-254   DOI   ScienceOn
13 Dolinoy DC, Environmental epigenomic in human health and disease. Environmental and Molecular Mutagenesis, 2008 ; 49 : 4-8   DOI   ScienceOn
14 Vaissiere T, Sawan C, Herceg E, Epigenetic interplay between histone modification and DNA methylation in gene silencing. Mutation Research, 2008 ; 659 : 40-48   DOI   ScienceOn
15 Geiman TM, Robertson KD, Chromatin remodeling, histone, modification, and DNA methylation - How does it all fit together ; Journal of Cellular Biochemistry, 2002 ; 87 : 117-125   DOI   ScienceOn
16 Waterland R, Michels K, Epigenetic epidemiology of the developmental origins hypothesis. Annu Rev Nutr, 2007 ; 27 : 363-88   DOI   ScienceOn
17 Dubos RJ, 적응하는 인간(上下). 이화여자대학교 출판부, 1987
18 Burdge G, Hanson M, Slater-Jefferies J, Lillycrop K. Epigenetic regulation of transcription : A mechanism for inducing variations in phenotype(fetal programming) by differences in nutrition during early life?. Br J Nutr, 2007 ; 97(6) : 1036-1046   DOI   ScienceOn
19 Merico V, Berbieri J, Zuccotti M, Joffe B, Cremer T, Redi CA, Solovei I, Garagna S. Epigenomic differentiation in mouse preimplantation nuclei of biparental, parthenote and cloned embryos. Chromosome Research, 2007 ; 15 : 341-360
20 Gluckman PD, Hanson MA, Cooper C, Thronburg KL, Effect of in utero and early-life conditions on adult health and disease. NEJM, 2008 ; 359(1) : 61-73   DOI   ScienceOn
21 Schanen NC. Epigenetics of autism spectrum disorders. Hum Mol Genet, 2006 ; 15(spec No 2) : R138-R150.
22 Martin C, Ehang Yi, Mechanism of epigenetic inheritance. Current Opinion in Cell Biology, 2007 ; 19 : 266-272   DOI   ScienceOn
23 Gronbaek K, Hother C, A-Jones P, Epigenetic changes in cancer. APMIS, 2007 ; 115 : 1039-1059   DOI
24 Bird A, Perceptions of epigenetics. Nature, 2007 ; 447 : 396-398   DOI   ScienceOn
25 Bolin C, Basha R, Cox D, Zawia N, Maloney B, Lahiri D, Cardozo-Pelaez F, Exposure to lead(Pb) and the developmental origin of oxidative DNA damage in the aging brain. The FASEB Journal, 2006 ; 1-19.
26 Mulero-Navarro S, Esteller M, Epigenetic biomarker for human cancer ; The time is now. Critical Reviews in Oncology Hematology, 2008 ; 68 : 1-11   DOI   ScienceOn
27 Steinke JW, Rich SS, Borish L, S. Genetics of allergic disease. J Allergy Clin Immunol, 2008 ; 121(2 suppl) : S384-S387quiz S416
28 Santos F, Hendrich B, Reik W, Dean W, Dynamic reprogramming of DNA methylation in the early mouse embryo. Developmental Biology, 2002 ; 241 : 172-182   DOI   ScienceOn
29 Bjornsson HT, Fallin MD, Feinberg AP, An integrated epigenetic and genetic approach to common human disease. Trends in Genetics, 2004 ; 20(8) : 350-358   DOI   ScienceOn
30 Egger G, Liang G, Aparicio A, Jones PA, Epigenetics in human disease and prospects for epigenetic therapy. Nature, 2004 ; 429 (27) : 457-463
31 Balch C, Montgomery JS, Paik HI, Kim S, Huang T H-M, Nephew KP, New anti-cancer strategies ; Epigenetic therapies and biomarkers. Frontiers in Bioscience, 2005 ; 10 : 1897-1931   DOI
32 Esteller M, Epigenetic in cancer. NEJM, 2008 ; 358 : 1148-59   DOI   ScienceOn
33 Campio J, Milagro FI, Martinez JA, Individuality and epigenetics in obesity. Obesity Reviews, 2009 : 1-10
34 Ling C, Guerra SD, Lupi R, Ronn T, Gramhall C, Luthman H, Masiello P, Marchett P, Groop L, Del Prato S, Epigenetic regulation of PPARGCIA in human type 2 diabetic islet and effect on insulin secretion. Diabetologia, 2008 ; 51 : 615-622   DOI   ScienceOn
35 Miller G, Chen E, Cole SW, Health psychology ; Developing biological plausible models linking the social world and physical health. Annu Rev Psychol, 2009 ; 60 : 501-24   DOI   ScienceOn
36 Hoover RN, Cancer-nature, nuture or both. NEJM, 2000 ; 343 : 135-136   DOI   ScienceOn
37 Adler NE, Newman K, Socioeconomic disparties in health : Pathways and policies. Health Afairs, 2002 ; 21(2) : 60-72   DOI   ScienceOn
38 Hanefeld J, How have global health initives impacted on health equality?. Pront Educ, 2008 ; 15(1) : 19-23
39 Lichtenstein P, Holm N, Verkasalo P, Iliadou A, Kaprio J, Koskenvuo M, Pukkala E, Skytthe A, Hemminiki K, Environmental and heritable factors in the Causation of cancer. NEJM, 2000 ; 343(3) : 78-85
40 Chakravarti A, Little P, Nature, nuture and human disease. Nature, 2003 ; 421(23) : 412-414
41 Eriksson JE, Epidemiology, genes and the environment ; lession learned from the Helsinki birth Cohort study. Journal of Internal Medicine, 2007 ; 261 : 418-425   DOI   ScienceOn
42 Barros SP, offenbacher S, Epigenetic : Connecting environment and genotype to phenotype and disease. J Dent Res, 2009 ; 88(5) : 400-408   DOI   ScienceOn
43 Wong Albert HC, Gottesman II, Petroanis A, Phenotypic differences in genetically identical organism ; The epigenetic perspective. Human Molecular Genetic, 2005 ; 14(1) : R11-R18
44 Berkman RF, Kawichi I, Social epidemiology. 2000. NY : Oxford Univ. press
45 마이클 마멋 지음, 김보영 옮김, 사회적 지위가 건강과 수명을 결정한다. 에코리브르, 2006
46 윌리엄 코커햄 지음, 박호진역, 의료사회학. 아커넷, 2005.
47 정경균 외 지음, 보건사회학 강좌. 신광출판사, 2004.
48 Mary NH, George AK, Leonard S, 4, Socioeconomic status and health ; Old observations and new thoughts, In Bunker JP, Gomby DS Rehrer Bl eds, Pathways to health ; The role of social factors. Menlo Park, CA ; Heny J Kaiser Family Foundation, 1989. 76-135
49 Vander Heyden J.H.A., Shaap MM, Kunst AE, Borrell EC, Cox B, Leinsalu B, Stirbu I, Kalediene R, Deboosere P, Mackenbach JP, Van Oyen H, Scioeconomic inequalities in lung cancer mortality in 16 European populations. Lung Cancer, 2009 ; 63 : 322-330   DOI   ScienceOn
50 Siegrist J, Marmot M, Health inequalities and the psychosocial environmental-two scientific challenges. Social Science and Medicine, 2004 ; 58 : 1463-1473   DOI   ScienceOn
51 Jo CP, Brace G, Link controlling disease and creating disparities(Topic1. structural patterns of health inequalities). Journal of Gerontology : series B, 2005 : 60B(Special Issue II) : 27-33
52 Bjornelv S, Lydersens HJ, Nilsen TI, Holmen TL, Sex differences in time trends for over weight and obesity in adolesents ; the young-HUNT study, Scand J. Public Health, 2009 ; Sep : 7
53 Mackenbach JP, Stirbu I, Roskam Albert- Jan R, Schaap MM, Menvielle Gwenn, Leinsalu Mall, Kunst AE, Socioeconomic inegualities in health In 22 European counturies. NEJM, 2008 ; 358(23) ; 2468-81   DOI   ScienceOn
54 Damanhori A, Al Khaja KAJ. Sequeira RP, Gender-based treatment outcomes in diabetic hypertension. J Postgrad Med, 2008 ; 54 : 252-8   DOI   ScienceOn
55 Lisa MB, Olena H, Kristen WS, Gender and health inequities ; A comment on the final report of the WHO commission on the social determinants of health social science and medicine. 2009 ; 1-3
56 Anita K, Ingemar K, Qiu C, Tom B, Bengt w, Laura F, Relation of education and occupation-based socioeconomic status to incident Alzheimer's disease, American Journal of Epidemiology, 2004 ; 159(2) : 175-183   DOI   ScienceOn
57 문창진, 보건의료사회학. 신광출판사, 1997
58 Jirtle R, Skinner M. Environmental epigenomics and disease susceptibility. Nature, 2007 ; 8 : 253-262.
59 Waggoner D, Mechanisms of disease : Epigenesis. Seminars in Pediatric Neurology, 2007 : 7-14
60 Waterland R, Michels K, Epigenetic epidemiology of the developmental origins hypothesis. Annu Rev Nutr, 2007 ; 27 : 363-88   DOI   ScienceOn
61 Wilson AG, Epigenetic regulation of gene expression in the inflammatory response and relevance to common disease. J Reviodontol, 2008 ; 79(8) : s1514-1519
62 Mathers JC. Personalized nutrition epigenetics : A basis for understanding individual differences. Procedings of the Nutrition Society, 2008 ; 67 ; 390-394   DOI
63 Hoffman EP, Skipping toward personalized molecular medicine. NEJM, 2007 ; 357(26) : 2719-2722   DOI   ScienceOn
64 Jain KK, Personalized medicine. Curr Opin Mol Ther, 2002. Dec ; 4(6) ; 548-58
65 Lundy B, Race, ethnicity, and health. Can genetic explain disparities ; Perspectives in Biology and Medicine, 2002 ; 45(2) : 159-74   DOI
66 Lavera MC, Racial, culture, and ethnic factors influencing end-of-life care. Journal of Palliative Medicine, 2005 ; 8(1) : s58-s70   DOI   ScienceOn
67 Poulsen P, Kyvik KO, Vaag A, Beck- Nielsen H. Heritability of type II(noninsulin- dependent) diabetes mellitus and abnormal glucose tolerance-a populationbased twin study. Diabetologia, 1999 ; 42 : 139-145   DOI   ScienceOn
68 Eckhardt RB, Genetic research and nutrional individuality. J Nutr, 2001. Feb ; 131(2) : 336s-9s
69 Edward JC, Biochemical individuality : The next generation. Regul Toxicol Pharmacol, 1996. Aug ; 24(1pt2):s58-67   DOI   ScienceOn
70 Cardno AG, Cottesman, I.I. II. Twin studies of schizophrenia : From bow-andarrow concordances to star wars Mx and functional genomics. Am J Med Genet, 2000 ; 97 : 12-17   DOI   ScienceOn
71 Bertelsen A, Harvald B, Hauge M. A Danish twin sudy of manic-depressive disorders. Br J Psychiatry, 1977 ; 130 : 330-51   DOI   ScienceOn
72 Baker SG. Lichtenstein P, Kaprio J. Holm W. Genetic susceptibility to prostate, breast, and colorectal cancer among nordic twins. Biometric, 2005 ; 61(1) : 55-63   DOI   ScienceOn
73 Petronis A, Epigenetics and twins ; three variations on the theme. Trends in genes, 2006 ; 22(7) : 347-350   DOI   ScienceOn
74 Pernille P, Manel E, Allan V, Mario FF, The epigenetic basis of twin discordance in age-related diseases. Pediatric Research, 2007 ; 61(5) : 38R-42R
75 Lijabeth AA, Fundamental molecular biology. Blackwell publishing Ltd, Oxford 2009.
76 Bruce RK, Integration of genetic into medical practice. Growth Hormone and IGF Research, 2004 ; 14 : S146-S149
77 Hardy J, Singleton A, Genomewide Association Studies and Human Disease. NEJM, 2009 ; 360(17) : 1759-68   DOI   ScienceOn
78 Tom Strachan, Andrew P. Human Molecular Genetics. Wiley-Liss publisher, 3rd edition. 2003.