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Method Validation for Monitoring of Agricultural Worker Exposure to Insecticide Fenthion  

Kim, Eun-Hye (Department of Agricultural Biotechnology, Seoul National University)
Lee, Hye-Ri (Department of Agricultural Biotechnology, Seoul National University)
Choi, Hoon (National Institute of Food and Drug Safety Evaluation)
Moon, Joon-Kwan (School of Plant, Life and Environmental Sciences, Hankyong National University)
Hong, Soon-Sung (National Institute of Agricultural Science and Technology)
Jeong, Mi-Hye (National Institute of Agricultural Science and Technology)
Park, Kyung-Hun (National Institute of Agricultural Science and Technology)
Lee, Hyo-Min (Risk Information Division, Risk Prevention Policy Bureau, Korea Food and Drug Administration)
An, Xue Hua (Zhejiang Academy of Agricultural Sciences)
Kim, Jeong-Han (Department of Agricultural Biotechnology, Seoul National University)
Publication Information
The Korean Journal of Pesticide Science / v.15, no.4, 2011 , pp. 357-365 More about this Journal
Abstract
Exposure measurement of agricultural worker to pesticide is one of important part of health risk assessment of pesticide. Therefore exposure matrices, apparatus, instruments and methods must be validated in advance to field experiment. In this study, method validation with an organophosphorus insecticide fenthion was carried out for exposure monitoring of agricultural worker. LOD and LOQ were 0.01 and 0.05 ng, respectively. Calibration curve linearity ($R^2$ > 0.999) and reproducibility (C.V. < 3%) were also excellent. Recovery at LOQ, 10LOQ and 100LOQ levels from gloves, socks, mask, patch, solid sorbent, glass fiber filter was 76~113% (C.V. < 3%). Trapping efficiency was 95~105% while no breakthrough was observed. Method validation for the exposure monitoring was established successfully through several experiments. Such method validation can be usually performed in laboratory and not much different for each pesticide so that, this techniques will be applied widely in research for pesticide exposure monitoring by combination with body surface area and respiration rates.
Keywords
Fenthion; exposure; method validation;
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Times Cited By KSCI : 3  (Citation Analysis)
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