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Thyroid Hormone-like Activity of Metribuzin as a Endocrine Disruptor in Rats and HeLaTRE Cell Culture  

You, Are-Sun (Division of Pesticide Safety Evaluation, Department of Crop Life Safety, National Academy of Agricultural Sciences)
Jeong, Mi-Hye (Division of Pesticide Safety Evaluation, Department of Crop Life Safety, National Academy of Agricultural Sciences)
Lee, Je-Bong (Division of Pesticide Safety Evaluation, Department of Crop Life Safety, National Academy of Agricultural Sciences)
Park, Yoen-Ki (Division of Pesticide Safety Evaluation, Department of Crop Life Safety, National Academy of Agricultural Sciences)
Shin, Jin-Sup (Division of Pesticide Safety Evaluation, Department of Crop Life Safety, National Academy of Agricultural Sciences)
Park, Kyung-Hun (Division of Reclaimed land agriculture Research, Department of Rice and Winter, National Institute of Crop Science)
Publication Information
The Korean Journal of Pesticide Science / v.12, no.4, 2008 , pp. 342-350 More about this Journal
Abstract
This study was carried out to investigate the suitability of the pubertal assay and the enhanced TG 407 as methods for detection of endocrine-mediated effects. Thyroid function was also considered. Male and female Sprague-Dawley rats were gavaged daily with 0, 25, 50, 100 mg/kg metribuzin in corn oil during 30 days. The effects of metribuzin on thyroid gland, the genital organs and thyroid hormone were measured in male and female rats. Dose of metribuzin 50 mg/kg/day increased relative weight of testis, prostate, and seminal vesicle in male rats but relative weight of thyroid gland was not significantly different from control group. Dose of metribuzin 25 mg/kg/day decreased relative weight of thyroid gland in female rats. Another purpose of this study was to investigate the effects of endocrine-disruptors as like thyroid hormone in vitro. Luciferase activity was measured to detect reaction of test chemicals and thyroid hormone response elements in HeLaTRE cell. Dose of metribuzin from 1 to 1,000 nM increased to 106-122% of luciferase activity.
Keywords
metribuzin; thyroid hormone; endocrine disruptor;
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