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Synthesis of 2(5H)-Furanones and 2-Cycloalkenones and Their Fungicidal Activities  

Heo, Jung-Nyoung (Korea Research Institute of Chemical Technology)
Song, Young-Seob (Korea Research Institute of Chemical Technology)
Park, No-Kyun (Korea Research Institute of Chemical Technology)
Choi, Gyung-Ja (Korea Research Institute of Chemical Technology)
Jang, Kyung-Soo (Korea Research Institute of Chemical Technology)
Kim, Bum-Tae (Korea Research Institute of Chemical Technology)
Publication Information
The Korean Journal of Pesticide Science / v.11, no.1, 2007 , pp. 1-7 More about this Journal
Abstract
We have developed an efficient synthesis of 2(5H)-furanones using the microwave-promoted Suzuki-Miyaura coupling reaction and evaluated their fungicidal activities against six fungal pathogens in vivo. In addition, 2-cyclopentenones or 2-cyclohexenones possessing one or two additional methylene groups instead of the oxygen in the 2(5H)-furanone skeleton were also prepared by using the similar method. As the results of in vivo fungicidal screening against 6 plant diseases, a few derivatives displayed specific fungicidal activities against rice blast and tomato late blast. Further studies toward the optimization of the chemical structures are necessary for the development of novel fungicides with high potency.
Keywords
plant disease controlling effect; furanone; cycloalkenone; cyclopentenone; cyclohexenone;
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