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Practical synthesis of a new insecticide, 1-(2,6-difluorobenzoy)-3-(3,5-bistrifluoro-methyl-2-chlorophenyl) urea (DBI-3204)  

Whang, Ill-Sun (Korea Research Institute of Chemical Technology)
Kim, Sun-Ok (Korea Research Institute of Chemical Technology)
Kim, Jung-Ho (Hanwha Chemical Research and Development Center)
Chung, Kun-Hoe (Korea Research Institute of Chemical Technology)
Publication Information
The Korean Journal of Pesticide Science / v.6, no.2, 2002 , pp. 105-109 More about this Journal
Abstract
Synthetic method of a new benzoylphenylurea insecticide, DBI-3204 [1-(2,6-Difluorobenzoyl)-3-(3,5-bistrifluoromethyl-2-chlorophenyl) urea] was established for manufactural production; 2,6-Difluorobenzoylisocyanate was synthesized by the reaction of 2,6-difluorobenzamide with oxalylchloride in 95% yields, the reaction of 3,5-bis(trifluoromethyl)aniline with N-chlorosuccinimde gave 3,5-bis (trifluoromethyl)-2-chloroaniline in 92% yields, and DBI-3204 was got from 2,6-difluorobenzoylisocyanate and 3,5-bis(trifluoromethyl)-2-chloroaniline in 90% yields. All the process was simplified by using the same reaction solvent, carbontetrachloride.
Keywords
insecticide; benzoylphenyl urea; chitin synthase; insect;
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