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http://dx.doi.org/10.5307/JBE.2004.29.5.467

The Biomechanical Characteristics of Isoflavone-Treated Ovariectomized Rat's Femur  

Kang S. (National Institute of Agricultural Engineering, RDA)
Park Y. H. (Institute of Life Science & Natural Resources, Korea University)
Paik M, K. (Department of Food and Nutrition, Hanyang University)
Om A. S. (Department of Food and Nutrition, Hanyang University)
Publication Information
Journal of Biosystems Engineering / v.29, no.5, 2004 , pp. 467-474 More about this Journal
Abstract
This study was to investigate the biomechanical characteristics of isoflavone-treated ovariectomized growing rat's femur. 4-week-old Wistar (female rats were randomly divided into 5 groups and assigned to sham(SH) group, and four ovariectomized groups consisting of one ovariectomized(OVX) group and genisetin(10 mg/kg b.w. )(OVX+G), daidzein(10 mg/kg b.w.)(OVX+D), and 17 $\beta$-estradiol(10 $\mu$g/kg b.w.)(OVX+ES) in AIN-76 modified diet for 8 weeks. The OVX groups gained more body weight than the SH group. Femoral weight was increased by feeding genistein and estradiol, whereas femoral length among groups was not significantly different. The breaking farce, stiffness, deformation, and energy values of the OVX group were lower than those of other groups. The stress, strain, and Young's modulus values of the OVX group were higher than those of other groups.
Keywords
Biomechanics; Isoflavone; Femur; Ovariectomized rat.;
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