Browse > Article
http://dx.doi.org/10.5393/JAMCH.2011.36.2.101

Cross-Sectional Relations of Arterial Stiffness and Inflammatory Markers in Korean Adults Aged 50 Years and Older  

Ryu, So-Yeon (Department of Preventive Medicine, Chosun University Medical School)
Shin, Min-Ho (Department of Preventive Medicine, Chonnam National University Medical School)
Lee, Young-Hoon (Department of Preventive Medicine, Wonkwang University College of Medicine)
Rhee, Jung-Ae (Department of Preventive Medicine, Chonnam National University Medical School)
Choi, Jin-Su (Department of Preventive Medicine, Chonnam National University Medical School)
Park, Kyeong-Soo (Department of Preventive Medicine, Seonam University College of Medicine)
Nam, Hae-Sung (Department of Preventive Medicine, Chungnam National University Medical School)
Jeong, Seul-Ki (Department of Neurology, Chonbuk National University Medical School)
Kweon, Sun-Seog (Department of Preventive Medicine, Chonnam National University Medical School)
Publication Information
Journal of agricultural medicine and community health / v.36, no.2, 2011 , pp. 101-112 More about this Journal
Abstract
Objectives: The aim of this study is to determine arterial stiffness levels as measured by brachial-ankle pulse wave velocity (baPWV) and to identify the association between arterial stiffness and inflammatory markers, in healthy adults over 50 years old. Methods: The study population consisted of 4617 persons over the age of 50 years who participated in the baseline survey of the Dong-gu Study, which was conducted in 2007 and 2008. Arterial stiffness was measured using baPWV. A multiple regression analysis was performed to assess the relationship between conventional cardiovascular risk factors and inflammatory markers, including white blood cell (WBC) counts, high-sensitive C-reactive protein (hs-CRP), and gamma glutamyltransferase (GGT). Results: After adjustment for conventional cardiovascular risk factors including sex, age, smoking status, body mass index, systolic blood pressure, fasting glucose, hypertension or diabetic medication, total cholesterol, triglycerides, uric acid, and alanine aminotransferase, baPWV was significantly associated with WBC counts (${\beta}$=0.158, p<0.0001), hs-CRP (${\beta}$=0.244, p=0.026), and GGT (${\beta}$=0.003, p<0.0001). Conclusion: This study shows that arterial stiffness correlates with inflammatory markers. Arterial stiffness may be used as a composite risk factor to identify persons with higher risk for cardiovascular disease. Additionally, arterial stiffness may be a marker for future cardiovascular disease and a target for prevention.
Keywords
Arterial stiffness; Inflammation; Pulse wave velocity;
Citations & Related Records
Times Cited By KSCI : 4  (Citation Analysis)
연도 인용수 순위
1 Saijo Y, Utsugi M, Yoshioka E, Horikawa N, Sato T, Gong Y, Kishi R. The relationship of gamma glutamyltransferase to C-reactive protein and arterial stiffness. Nutr Metab Cardiovasc Dis 2008;18:211-219   DOI
2 Statistics Korea. 2009 Annual report on the cause death statistics. Daejeon: Statitisc Korea, 2010 (Korean)
3 예방의학 편찬위원회. 예방의학 서울: 계축문화사, 2011, pp291-302
4 Jo YK, Jeon JY, Kim ES, Kekal YS, Eom YB, Im JA. Determinats of arterial stiffness in young adults. J Exp Biomed Sci 2006;12:191-196
5 Cohn JN. Arterial compliance to stratify cardiovascular risk: more precision in therapeutic decision making. Am J Hypertens 2001;14:258S-263S   DOI
6 Slotwiner DJ, Devereux RB, Schwartz JE, Pickering TG, de Simone G, Ganau A, Saba PS, Roman MJ. Relation of age to left ventricular function in clinically normal adults. Am J Cardiol 1998;82(5):621-626   DOI
7 Blacher J, Asmar R, Djane S, London GM, Safar ME. Aortic pulse wave velocity as a marker of cardiovascular risk in hypertensive patients. Hypertension 1999;33(5):1111-1117   DOI   ScienceOn
8 Mortolotto LA, Blacher J, Kondo T, Takazawa K, Safar ME. Assessment of vascular aging and atherosclerosis in hypertensive subjects : second derivative of photoplethsmogram versus pulse wave velocity. Am J Hypertens 2000;13:165-171   DOI
9 Tsai WC, Chen JY, Wang MC, W u HT, Chi CK, Chen YK et al. Association of risk factors with increased pulse wave velocity detected by a novel method using dual-channel photoplethysmography. Am J Hypertens 2005;18:1118-1122   DOI
10 Dart AM, Kingwell BA. Pulse pressure - a review of mechanism and clinical relevance. J Atherosclero Thromb 2006;13:101-107   DOI
11 Fujiwara Y, Chaves P, Takahashi R, Amano H, Kumagai S, Fujuta K, Yoshida H, Wang DG, Varadhan R, Uchida H, Shinkai S. Relationships between brachial-ankle pulse wave velocity and conventional atherosclerotic risk factors in community-dwelling people. Prev Med 2004;39:1135-1142   DOI
12 Jousilahti P, Rastenyte D, Tuomilehto J. Serum gamma-glutamyltransferase, selfreported alcohol drinking, and the risk of stroke. Stroke 2000;31:1851-1855   DOI
13 Laurent S, Cockcrofe J, Van Bortel L, Boutouyrie P, Giannattasia C, Hayoz D, et al. European network for non-invasive investigation of large arteries expert consensus document on arterial stiffness: methodological issues and clinical applications. Eur Heart J 2006;27:2588-2605   DOI
14 Lee DH, Blomhoff R, Jacobs Jr DR. Is serum gamma glutamyltransferase a marker of oxidative stress? Free Radic Res 2004;38:535-539   DOI
15 Karp DR, Shimooku K, Lipsky PE. Expression of gamma-glutamyl transpeptidase protects ramos B cells from oxidationinduced cell death. J Biol Chem 2001;276;3798-3804   DOI
16 Paolicchi A, Dominici S, Pieri L, Maellaro E, Pompella A. Glutathione catabolism as a signaling mechanism. Biochem Pharmacol 2002;64:1027-1035   DOI   ScienceOn
17 Resnick HE, Lindsay RS, McDermott MM, et al. Relationship of high and low ankle-brachial index to all-cause and cardiovascular disease mortality : the Strong Heart Study. Circulation 2004;109:733-739   DOI
18 Papamichael C, Lekakis JP, Stamatelopoulos KS, et al. Ankle-brachial index as a predictor of the extent of coronary atherosclerosis and cardiovascular events in patients with coronary artery disease. Am J Cardiol 2000;86:615-618   DOI
19 Ross R. Atherosclerosis- an inflammatory disease. N Engl J Med 1999;340:115-126   DOI
20 Steinberg D, Parthasarathy S, Carew TE, Khoo JC, Witztum JL. Beyond cholesterol. Modifications of low-density lipoprotein that increase its atherogenicity. N Engl J Med 1989;320:915-924   DOI
21 Pande RL, Perlstein TS, Beckman JA, Creager MA. Association of insulin resistance and inflammation with peripheral arterial disease : The National Health and Nutrition Examination Survey, 1999 to 2004. Circulation 2008;118:33-41   DOI
22 Shoelson SE, Lee J, Goldfine AB. Inflammation and insulin resistance. J Clin Invest 2006;116:1793-1801   DOI
23 Teschke R, Brand A, Strohmeyer T. Induction of hepatic microsomal gamma-glutamyltransferase activity following chronic alcohol consumption. Biochem Biophys Res Commun 1977;75:718-724   DOI
24 Wannamethee G, Ebrahim S, Shaper AG. Gamma-glutamyltranspeptidase : determinants and association with mortality from ischemic heart disease and all causes. Am J Epidemiol 1995;142:699-708   DOI
25 Munakawa M, Ito N, Nunokawa T, Yoshinaga K. Utility of automated brachial arterial ankle pulse wave velocity measurements in hypertensive patients. Am J Hypertens 2003;16:653-657   DOI
26 Lee MS, Park HS, Park JH, Lee JH, Choi SW, Jeong JO, Gu BJ, Kim DH, Kim J, Lee TY, Sung IW. Increased Serum Ferritin Concentration is Associated with Increased Arterial Stiffness Assessed by Pulse Wave Velocity. Korean J Lipid Atherosclerosis 2006;16:281-288(Korean)   과학기술학회마을
27 Kim JS, Kang TS, Kim JB, Se o HS, Park S, Kim C, Ko YG, Choi D, Jang Y, Chung N. Significant association of C-reactive protein with arterial stiffness in treated non-diabetic hypertensive patients. Atherosclerosis 2007;192:401-406   DOI
28 Kweon SS, Shin MH, Park KS, Nam HS, Jeong SK, Ryu SY, Chung EK, Choi JS. Distribution of the ankle-brachial index and associated cardiovascular risk factors in a population of middle-aged and elderly Koreans. J Korean Med Sci 2005;20:373-378   과학기술학회마을   DOI
29 Woo J, Lynn H, Wong SYS, Hong A, Tang YN, Lau WY, et al. Correlates for a low ankle-brachial index in elderly Chinese. Atherosclerosis 2006;186:360-366   DOI
30 Zheng ZJ, Sharrett AR, Chambless LE, et al. Associations of ankle-brachial index with clinical coronary heart disease, stroke, and preclinical carotid and popliteal atherosclerosis: the Atherosclerosis Risk in Community (ARIC) study. Atherosclerosis 1997;131:115-125   DOI
31 Bernstein EF, Fronek A. Current status of non-invasive tests in the diagnosis of peripheral arterial disease. Surg Clin North Am 1982;62:473-487   DOI
32 Yasmin, McEniery CM, Wallace S, Mackenzie IS, Cockcroft JR, Wilkinson IB. C-reactive protein is associated with arterial stiffness in apparently health individuals. Arterioscler Thromb Vasc Biol 2004;24:969-974   DOI
33 Murabito JM, Evans JC, Larson MG, Nieto K, Levy D, Wilson PW. The ankle-brachial index in the elderly and risk of stroke, coronary disease and death : the Framingham Study. Arch Int Med 2003;163:1939-1942   DOI
34 Mitchell GF, Parise H, Benjamin EJ, Larson MG, Keyes MJ, Vita JA, Vasan RS, Levy D. Changes in arterial stiffness and wave reflection with advancing age in healthy men and women: the Framingham Heart Study. Hypertension 2004;43:1239-1245   DOI
35 Tomiyama H, Yamashina A, Arai T, Hirose K, Koji Y, Chikamori T, Hori S, Yamamoto Y, Doba N, Hinohara S. Influences of age and gender on results of noninvasive brachial-ankle pulse wave velocity measurement-a survey of 12517 subjects. Atherosclerosis 2003;166:303-309   DOI
36 Kullo IJ, Seward JB, Bailey KR, Bielak LF, Grossardt BR, Sheedy PF II, Peyser PA, Turner ST. C-reactive protein is related to arterial wave reflection and stiffness in asymptomatic subjects from the community. Am J Hypertens 2005;18:1123-1129   DOI
37 Tomiyama H, Arai T, Koji Y, Yambe M, Hirayama Y, Yamamoto Y, Yamashina A. The relationship between high-sensitive C-reactive protein and pulse wave velocity in healthy Japanese men. Atherosclerosis 2004;174:373-377   DOI
38 Nagano M, Nakamura M, Sato K, Tanaka F, Segawa T, Hiramori K. Association between C-reactive protein levels and pulse wave velocity: a population-based cross-sectional study in a general population. Atherosclerosis 2005;180:189-195   DOI
39 Mattace-Raso F, van der Cammen T, van der Meer I, Sxhalekamp M, Asmar R, Hofman A, Witteman J. C-reactive protein and arterial stiffness in older adults : the Rotterdam Study. Athersclerosis 2004;176:111-116   DOI