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http://dx.doi.org/10.9717/kmms.2021.24.4.583

Alteration of Functional Connectivity in OCD by Resting State fMRI  

Kim, Seungho (Dept. of Medical & Biological Eng., Graduate School, Kyungpook National University)
Lee, Sang Won (Dept. of Psychiatry, School of Medicine, Kyungpook National University and Dept. of Psychiatry, Kyungpook National University Chilgok Hospital)
Lee, Seung Jae (Dept. of Psychiatry, School of Medicine, Kyungpook National University and Dept. of Psychiatry, Kyungpook National University Hospital)
Chang, Yongmin (Dept. of Molecular Medicine, School of Medicine, Kyungpook National University and Dept. of Radiology, Kyungpook National University Hospital)
Publication Information
Journal of Korea Multimedia Society / v.24, no.4, 2021 , pp. 583-592 More about this Journal
Abstract
Obsessive-compulsive disorder (OCD) is a mental disorder in which a person repeated a particular thought or feels. The domain of beliefs and guilt predicted OCD symptoms. Although there were some neuroimaging studies investigating OCD symptoms, resting-state functional magnetic resonance imaging (rs-fMRI) study investigating intra-network functional connectivity associated with guilt for OCD is not reported yet. Therefore, in the current study, we assessed the differences between intra-network functional connectivity of healthy control group and OCD group using independent component analysis (ICA) method. In addition, we also aimed to investigate the correlation between changed functional connectivity and guilt score in OCD. Total 86 participants, which consisted of 42 healthy control volunteers and 44 OCD patients, acquired rs-fMRI data using the 3T MRI. After preprocessing the fMRI data, a functional connectivity was used for group independent component analysis. The results showed that OCD patients had higher score in emotion state in beliefs and lower functional connectivity in fronto-parietal network (FPN) than control group. A decrease of functional connectivity in FPN was negatively correlated with feelings of guilt in OCD. Our results suggest excessive increase in guilt negatively affect to process emotional state and behavior or cognitive processing by influencing intrinsic brain activity.
Keywords
Obsessive-compulsive Disorder (OCD); Resting-state Functional Magnetic Resonance Imaging (rs-fMRI); Functional Connectivity; Independent Component Analysis;
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1 L. Tibi, P. Van Oppen, A. van Balkom, M. Eikelenboom, J. Rickelt, K. Schruers, et al., "The Long-term Association of OCD and Depression and Its Moderators: A Four-year Follow Up Study in a Large Clinical Sample," European Psychiatry, Vol 44, pp. 76-82, 2017.   DOI
2 D. Julien, K.P. O'Connor, F. Aardema, and C. Todorov, "The Specificity of Belief Domains in Obsessive-compulsive Symptom Subtypes," Personality and Individual Differences, Vol. 41, No. 7, pp. 1205-1216, 2006.   DOI
3 S. Rachman, "Obsessions, Responsibility and Guilt," Behaviour Research and Therapy, Vol. 31, No. 2, pp. 149-154, 1993.   DOI
4 J.P. Tangney and K.W. Fischer, Self-conscious Emotions: The Psychology of Shame, Guilt, Embarrassment, and Pride, The Guil-ford Press Publishers, New York, 1995.
5 C. Tilghman-Osborne, D.A. Cole, and J.W. Felton, "Inappropriate and Excessive Guilt: Instrument Validation and Developmental Differences in Relation to Depression," Journal of Abnormal Child Psychology, Vol. 40, pp. 607-620, 2012.   DOI
6 A. Gangemi, F. Mancini, and M. van den Hout, "Feeling Guilty as a Source of Information about Threat and Performance," Behaviour Research and Therapy, Vol. 45, No. 10, pp. 2387-2396, 2007.   DOI
7 F. Mancini, F. D'Olimpio, and L. Cieri, "Manipulation of Responsibility in Non-clinical Subjects: Does Expectation of Failure Exacerbate Obsessive-Compulsive Behaviors?," Behaviour Research and Therapy, Vol. 42, No. 4, pp. 449-457, 2004.   DOI
8 G. Melli, C. Carraresi, A. Poli, D. Marazziti, and A. Pinto, "The Role of Guilt Sensitivity in OCD Symptom Dimensions," Clinical Psychology & Psychotherapy, Vol. 24, pp. 1079-1089, 2017.   DOI
9 F.d. Boisgueheneuc, R. Levy, E. Volle, M. Seassau, H. Duffau, S. Kinkingnehun, et al, "Functions of the Left Superior Frontal Gyrus in Humans: A Lesion Study," Brain, Vol. 129, No. 12, pp. 3315-3328, 2006.   DOI
10 J. Long, L. Luo, Y. Guo, W. You, Q. Li, and B. Li, "Altered Spontaneous Activity and Effective Connectivity of the Anterior Cingulate Cortex in Obsessive-compulsive Disorder," Journal of Comparative Neurology, Vol. 529, No. 2, pp. 296-310, 2021.   DOI
11 W.H. Dittrich and T. Johansen, "Cognitive Deficits of Executive Functions and Decision-Making in Obsessive-Compulsive Disorder," Scandinavian Journal of Psychology, Vol. 54, No. 5, pp. 393-400, 2013.   DOI
12 S. Rachman and R. Shafran, Obsessive-Compulsive Disorder: Theory, Research, and Treatment, The Guilford Press Publishers, New York, 1998.
13 Y. Lee, "A Study of the Reliability and the Validity of the BDI, SDS, and MMPI-D Scales," Korean Journal of Clinical Psychology, Vol. 10, No. 1, pp. 98-113, 1991.
14 A. Hyvarinen, "Fast and Robust Fixed-point Algorithms for Independent Component Analysis," IEEE Transactions on Neural Networks, Vol. 10, No. 3, pp. 626-634, 1999.   DOI
15 V.D. Calhoun, T. Adali, G.D. Pearlson, and J.J. Pekar, "A Method for Making Group Inferences from Functional MRI Data Using Independent Component Analysis," Human Brain Mapping, Vol. 14, No. 3, pp. 140-151, 2001.   DOI
16 E.T. Bullmore, J. Suckling, S. Overmeyer, S. Rabe-Hesketh, E. Taylor, and M.J. Brammer, "Global, Voxel, and Cluster Tests, by Theory and Permutation, for a Difference between Two Groups of Structural MR images of the Brain," IEEE Transactions on Medical Imaging, Vol. 18, No. 1, pp. 32-42, 1999.   DOI
17 W.W. Seeley, V. Menon, A.F. Schatzberg, J. Keller, G.H. Glover, H. Kenna, et al., "Dissociable Intrinsic Connectivity Networks for Salience Processing and Executive Control," Journal of Neuroscience, Vol. 27, No. 9, pp. 2349-2356, 2007.   DOI
18 J.I. Kang, K. Namkoong, S.W. Yoo, K. Jhung, and S.J. Kim, "Abnormalities of Emotional Awareness and Perception in Patients with Obsessive-compulsive Disorder," Journal of Affective Disorders, Vol. 141, No. 2-3, pp. 286-293, 2012.   DOI
19 Y.-W. Kim and H.-B. Kang, "An Analysis on the Changes in ERP According to Type of Stimuli about Fear of Crime," Journal of Korea Multimedia Society, Vol. 20, No. 12, pp. 1856-1864, 2017.   DOI
20 J. Fan, M. Zhong, J. Gan, W. Liu, C. Niu, H. Liao, et al., "Altered Connectivity within and between the Default Mode, Central Executive, and Salience Networks in Obsessive-compulsive Disorder," Journal of Affective Disorders, Vol. 223, pp. 106-114, 2017.   DOI
21 S. Bannon, C.J. Gonsalvez, R.J. Croft, and P.M. Boyce, "Executive Functions in Obsessive-compulsive Disorder: State or Trait Deficits?," Australian & New Zealand Journal of Psychiatry, Vol. 40, pp. 1031-1038, 2006.   DOI
22 R.P. Swinson, M.M. Antony, S. Rachman, and M.A. Richter, Obsessive-Compulsive Disorder: Theory, Research, and Treatment, The Guilford Press Publishers, New York, 2001.
23 J.P. McNamara, A.M. Reid, A.M. Balkhi, R. Bussing, E.A. Storch, T.K. Murphy, et al., "Self-regulation and Other Executive Functions Relationship to Pediatric OCD Severity and Treatment Outcome," Journal of Psychopathology and Behavioral Assessment, Vol. 36, pp. 432-442, 2014.   DOI
24 Y.-H. Chen, S.-F. Li, D. Lv, G.-D. Zhu, Y.-H. Wang, X. Meng, et al., "Decreased Intrinsic Functional Connectivity of the Salience Network in Drug-naive Patients with Obsessive-compulsive Disorder," Frontiers in Neuroscience, Vol. 12, No. 889, pp. 1-7, 2018.
25 C.N. Lacerenza, D.L. Joseph, and J.E. Cassisi, "Are We Assessing Guilt Correctly? An Investigation of the Psychometric Properties of a Prominent Guilt Measure," Motivation and Emotion, Vol. 44, pp. 567-582, 2020.   DOI
26 S. Sharma, S. Vaish, J. Trivedi, and P. Dalal, "Neurocognitive Deficits in Obsessive Compulsive Disorder: A State or Trait Phenomenon?," Journal of Mental Health and Human Behaviour, Vol. 19, No. 2, pp. 78-82, 2014.   DOI
27 W. Fleeson, "Toward a Structure-and Process-integrated View of Personality: Traits as Density Distributions of States," Journal of Personality and Social Psychology, Vol. 80, No. 6, pp. 1011-1027, 2001.   DOI
28 J.P. Ospina, R. Jalilianhasanpour, and D.L. Perez, "The Role of the Anterior and Midcingulate Cortex in the Neurobiology of Functional Neurologic Disorder," Handbook of Clinical Neurology, Vol. 166, pp. 267-279, 2019.   DOI
29 M.A. Thornton, M.E. Weaverdyck, and D.I. Tamir, "The Brain Represents People as the Mental States They Habitually Experience," Nature Communications, Vol. 10, No. 1, pp. 1-10, 2019.   DOI
30 B. Basile, F. Mancini, E. Macaluso, C. Caltagirone, and M. Bozzali, "Abnormal Processing of Deontological Guilt in Obsessive-compulsive Disorder," Brain Structure and Function, Vol. 219, pp. 1321-1331, 2014.   DOI
31 L. Geerligs, M. Rubinov, and R.N. Henson, "State and Trait Components of Functional Connectivity: Individual Differences Vary with Mental State," Journal of Neuroscience, Vol. 35, No 41, pp. 13949-13961, 2015.   DOI
32 O.F. Goncalves, S. Carvalho, J. Leite, A. Fernandes-Goncalves, A. Carracedo, and A. Sampaio, "Cognitive and Emotional Impairments in Obsessive-compulsive Disorder: Evidence from Functional Brain Alterations," Porto Biomedical Journal, Vol. 1, No. 3, pp. 92-105, 2016.   DOI
33 B.J. Harrison, J. Pujol, C. Soriano-Mas, R. Hernandez-Ribas, M. Lopez-Sola, H. Ortiz, et al., "Neural Correlates of Moral Sensitivity in Obsessive-compulsive Disorder," Archives of General Psychiatry, Vol. 69, No. 7, pp. 741-749, 2012.   DOI
34 I. Fajnerova, D. Gregus, A. Francova, E. Noskova, J. Koprivova, P. Stopkova, et al., "Functional Connectivity Changes in Obsessive-compulsive Disorder Correspond to Interference Control and Obsessions Severity," Frontiers in Neurology, Vol. 11, No. 568, pp. 1-13, 2020.   DOI
35 B.P. Brennan, D. Wang, M. Li, C. Perriello, J. Ren, J.A. Elias, et al., "Use of an Individual-level Approach to Identify Cortical Connectivity Biomarkers in Obsessive-compulsive Disorder," Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, Vol. 4, No. 1, pp. 27-38, 2019.   DOI
36 V.D. Calhoun, J. Liu, and T. Adali, "A Review of Group ICA for fMRI Data and ICA for Joint Inference of Imaging, Genetic, and ERP Data," Neuroimage, Vol. 45, No. 1, pp. S163-S172, 2009.   DOI
37 S.G. Myers, P.L. Fisher, and A. Wells, "Belief Domains of the Obsessive Beliefs Questionnaire-44 (OBQ-44) and Their Specific Relationship with Obsessive-compulsive Symptoms," Journal of Anxiety Disorders, Vol. 22, No. 3, pp. 475-484, 2008.   DOI
38 S.-H. Jung, "Analysis of Hyperspectral Dentin Data Using Independent Component Analysis," Journal of Korea Multimedia Society, Vol. 12, No. 12, pp. 1755-1760, 2009.
39 W.H. Jones, A.K. Schratter, and K. Kugler, "The Guilt Inventory," Psychological Reports, Vol. 87, pp. 1039-1042, 2000.   DOI
40 R. Shafran, E. Watkins, and T. Charman, "Guilt in Obsessive-compulsive Disorder," Journal of Anxiety Disorders, Vol. 10, No. 6, pp. 509-516, 1996.   DOI
41 G. Steketee, R.O. Frost, and I. Cohen, "Beliefs in Obsessive-compulsive Disorder," Journal of Anxiety Disorders, Vol. 12, No. 6, pp. 525-537, 1998.   DOI
42 B. Basile and F. Mancini, "Neurobiological Mechanisms Underlying Abnormal Processing of Guilt, Disgust and Intentionality in Obsessive-compulsive Disorder: A Critical Review," Clinical Neuropsychiatry, Vol. 11, No. 6, pp. 187-193, 2014.
43 D.J. Stein, E. Hollander, C.M. DeCaria, and S. Trungold, "OCD: A Disorder with Anxiety, Aggression, Impulsivity, and Depressed Mood," Psychiatry Research, Vol. 36, No. 2, pp. 237-239, 1991.   DOI
44 Y. Takagi, Y. Sakai, Y. Abe, S. Nishida, B.J. Harrison, I. Martinez-Zalacain, et al., "A Common Brain Network among State, Trait, and Pathological Anxiety from Whole-brain Functional Connectivity," Neuroimage, Vol. 172, pp. 506-516, 2018.   DOI