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http://dx.doi.org/10.9717/kmms.2019.22.9.992

Analysis and 3D Reconstruction of a Cerebral Vascular Network Using Image Threshold Techniques in High-resolution Images of the Mouse Brain  

Lee, Junseok (Dept. of Computer Eng., Korea Army Academy at Yeongcheon)
Publication Information
Journal of Korea Multimedia Society / v.22, no.9, 2019 , pp. 992-999 More about this Journal
Abstract
In this paper, I lay the foundation for creating a multiscale atlas that characterizes cerebrovasculature structural changes across the entire brain of a mouse in the Knife-Edge Scanning Microscopy dataset. The geometric reconstruction of the vascular filaments embedded in the volume imaging dataset provides the ability to distinguish cerebral vessels by diameter and other morphological properties across the whole mouse brain. This paper presents a means for studying local variations in the small vascular morphology that have a significant impact on the peripheral nervous system in other cerebral areas, as well as the robust and vulnerable side of the cerebrovasculature system across the large blood vessels. I expect that this foundation will prove invaluable towards data-driven, quantitative investigations into the system-level architectural layout of the cerebrovasculature and surrounding cerebral microstructures.
Keywords
Knife-Edge Scanning Microscope; Whole Mouse Brain; Microvascular;
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1 S. Yulu and J.M. Wardlaw, "Update on Cerebral Small Vessel Disease: A Dynamic Whole-brain Disease," Stroke and Vascular Neurology, Vol. 1, No. 3, pp. 83-92, 2016.   DOI
2 D. Pinter, C. Enzinger, and F. Fazekas, "Cerebral Small Vessel Disease, Cognitive Reserve and Cognitive Dysfunction," Journal of Neurology, Vol. 262, No. 11, pp. 2411-2419, 2015.   DOI
3 J.M. Wardlaw, C. Smith, and M. Dichgans, "Mechanisms of Sporadic Cerebral Small Vessel Disease: Insights From Neuroimaging," The Lancet Neurology, Vol. 12, No. 5, pp. 483-497, 2013.   DOI
4 J.M. Wardlaw, M.S. Dennis, C.P. Warlow, and P.A. Sandercock, "Imaging Appearance of the Symptomatic Perforating Artery in Patients with Lacunar Infarction: Occlusion or Other Vascular Pathology?," Annals of Neurology, Vol. 50, No. 2, pp. 208-215, 2001.   DOI
5 G.E. Mead, S.C. Lewis, J.M. Wardlaw, M.S. Dennis, and C.P. Warlow, "How Well Does the Oxfordshire Community Stroke Project Classification Predict the Site and Size of the Infarct on Brain Imaging?," Journal of Neurology, Neurosurgery and Psychiatry, Vol. 68, No. 5, pp. 558-562, 2000.   DOI
6 B.H. McCormick and D.M. Mayerich, "Three-dimensional Imaging Using Knife-edge Scanning Microscopy," Microscopy and Microanalysis, Vol. 10, No. S02, pp. 1466-1467, 2004.   DOI
7 Y. Choe, L.C. Abbott, D. Han, P.S. Huang, J. Keyser, J. Kwon, et al., "Knife-edge Scanning Microscopy: High-throughput Imaging and Analysis of Massive Volumes of Biological Microstructures," High-Throughput Image Reconstruction and Analysis: Intelligent Microscopy Applications, pp. 11-37, 2008.
8 Y. Choe, D. Mayerich, J. Kwon, D.E. Miller, J.R. Chung, C. Sung, et al., "Knife-edge Scanning Microscopy for Connectomics Research," Proceeding of The 2011 International J oint Conference on Neural Networks, pp. 2258-2265, 2011.
9 M.J. Pesavento, C. Miller, K. Pelton, M. Maloof, C.E. Monteith, V. Vemuri, et al., "Knife-edge Scanning Microscopy for Brightfield Multi-cubic Centimeter Analysis of Microvasculature," Microscopy Today, Vol 25, No. 4, pp. 14-21, 2017.   DOI
10 Y. Choe, D. Mayerich, J. Kwon, D.E. Miller, C. Sung, J.R. Chung, et al., "Specimen Preparation, Imaging, and Analysis Protocols for Knife-edge Scanning Microscopy," Journal of Visualized Experiments, Vol. 58, No. e3248, pp. 1-11, 2011.
11 D. Mayerich, L. Abbott, and B. McCormick, "Knife-Edge Scanning Microscopy for Imaging and Reconstruction of Three-Dimensional Anatomical Structures of the Mouse Brain," Journal of Microscopy, Vol. 231, No. 1, pp. 134-143, 2008.   DOI
12 J.R. Chung, C. Sung, D. Mayerich, J. Kwon, D.E. Miller, T. Huffman, et al., "Multiscale Exploration of Mouse Brain Microstructures Using the Knife-edge Scanning Microscope Brain Atlas," Frontiers in Neuroinformatics, Vol 5, Article 29, pp. 1-17, 2011.   DOI
13 J. Prewitt and M.L. Mendelsohn, "The Analysis of Cell Images," Annals of the New York Academy of Sciences, Vol. 128, No. 1, pp. 1035-1053, 1966.
14 J. Lee, W. An, and Y. Choe, "Mapping the Full Vascular Network in the Mouse Brain at Submicrometer Resolution," Proceeding of 39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, pp. 3309-3312, 2017.
15 T.H. Bar and J.R. Wolff, "The Formation of Capillary Basement Membranes during Internal Vascularization of the Rat's Cerebral Cortex," Zeitschrift fur Zellforschung Und Mikroskopische Anatomie, Vol. 133, No. 2, pp. 231-248, 1972.   DOI
16 MATLAB Release, The Mathworks Inc., Natick, Massachusetts, United States, 2013.
17 O. Hunziker, H. Frey, and U. Schulz, "Morphometric Investigations of Capillaries in the Brain Cortex of the Cat," Brain Research, Vol. 65, No. 1, pp. 1-11, 1974.   DOI
18 M. Mato and S. Ookawara, "A Simple Method for Observation of Capillary Nets in Rat Brain Cortex," Experientia, Vol. 35, No. 4, pp. 501-503, 1979.   DOI
19 H. Michaloudi, C. Batzios, I. Grivas, M. Chiotelli, and G.C. Papadopoulos, "Developmental Changes in the Vascular Network of the Rat Visual Areas 17, 18 and 18a," Brain Research, Vol. 1103, No. 1, pp. 1-12, 2006.   DOI
20 B. Xiong, A. Li, Y. Lou, S. Chen, B. Long, J. Peng, et al., "Precise Cerebral Vascular Atlas in Stereotaxic Coordinates of Whole Mouse Brain," Frontiers in Neuroanatomy, Vol. 11, Article 128, pp. 1-17, 2017.
21 R.C. Gonzalez and R.E. Woods, Image Processing Toolbox User's Guide, The Mathworks Inc., Massachusetts, United States, 2000.
22 A. Georgantzoglou, J.D. Silva, and R. Jena, "Image Processing with Matlab and GPU," MATLAB Applications for the Practical Engineer , IntechOpen, 2014.
23 S. Lim, M.R. Nowak, and Y. Choe, "Automated Neurovascular Tracing and Analysis of the Knife-edge Scanning Microscope Rat Nissl Data Set Using a Computing Cluster," Proceeding of 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, pp. 6445-6448, 2016.
24 W.J. Schroder, K.M. Martin, and L.S. Avila, VTK User's Guide-VTK File Formats, Kitware, Inc., New York, United States, 2000.
25 U. Ayachit, The Paraview Guide: A Parallel Visualization Application, Kitware, Inc., New York, United States, 2015.
26 N.G. Conradi, J. Engvall, and J.R. Wolff, "Angioarchitectonics of Rat Cerebellar Cortex during Pre-and Postnatal Development," Acta neuropathologica, Vol. 50, No. 2, pp. 131-138, 1980.   DOI
27 H.S. Yoon, N. Hewage, C.W. Moon, Y.H. Kim, and H.K. Choi, "Design of 3D Visualization Software Tool based on VTK for Manual Brain Segmentation of MRI," Journal of Korea Multimedia Society, Vol. 8, No. 2, pp. 120-127, 2015.