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http://dx.doi.org/10.48022/mbl.2111.11011

A Study of Whitening Functional Activity Verification from Red Bean (Phaseolus angularis) Shell Extract  

Lee, Soo-Yeon (Division of Bio-Technology and Convergence, Daegu Haany University)
Oh, Min-Jeong (Division of Cosmetics and Biotechnology, Hoseo University)
Yeom, Hyeon-Ji (Division of Cosmetics and Biotechnology, Hoseo University)
Lee, Jin-Young (Division of Cosmetics and Biotechnology, Hoseo University)
Publication Information
Microbiology and Biotechnology Letters / v.50, no.2, 2022 , pp. 277-282 More about this Journal
Abstract
Whitening effect of the extract of Phaseolus angularis (PA) shell was investigated for its potential application as a functional ingredient for cosmetic products. The tyrosinase inhibitory effect, which is related to whitening, was 76.4% at a concentration of 1,000 ㎍/ml. Cell viability of melanoma cells was measured to test toxicity of the PA shell extract at concentrations showing at least 90% viability. In addition, western blot and RT-PCR assays of the PA shell extract showed concentration-dependent decreases of MITF, TRP-1, TRP-2 and tyrosinase protein and inhibitory effect of mRNA expression. These findings suggested that extract from PA shell has great potential as a cosmeceutical ingredient with whitening effect.
Keywords
Phaseolus angularis Shell; whitening effect; melanoma cell; skin pigmentation;
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