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http://dx.doi.org/10.48022/mbl.2202.02001

Oral Administration of Weissella confusa WIKIM51 Reduces Body Fat Mass by Modulating Lipid Biosynthesis and Energy Expenditure in Diet-Induced Obese Mice  

Lim, Seul Ki (Fermentation Regulation Technology Research Group, World Institute of Kimchi)
Lee, Jieun (Industrial Solution Research Group, World Institute of Kimchi)
Park, Sung Soo (Kimchi Functionality Research Group, World Institute of Kimchi)
Kim, Sun Yong (Pharmsville Co., Ltd.)
Park, Sang Min (Pharmsville Co., Ltd.)
Mok, Ji Ye (Pharmsville Co., Ltd.)
Chang, Hyunah (Pharmsville Co., Ltd.)
Choi, Hak-Jong (Kimchi Functionality Research Group, World Institute of Kimchi)
Publication Information
Microbiology and Biotechnology Letters / v.50, no.1, 2022 , pp. 135-146 More about this Journal
Abstract
Obesity is closely associated with profound dyslipidemia, insulin resistance, and fatty liver disease. Recent reports have suggested that alterations in gut microbiota can be linked to diet-induced obesity. In this study, the anti-obesity effects of Weissella confusa WIKIM51 isolated from kimchi were investigated, as evidenced by: i) reduced lipid accumulation and downregulated adipogenesis-related genes in 3T3-L1 adipocytes; ii) suppressed gains in body weight and epididymal fat mass; iii) reduced serum lipid levels, for example, triglyceride and total cholesterol; iv) increased serum adiponectin levels and reduced serum leptin levels; v) downregulated lipogenesis and upregulated β-oxidation-related genes in the epididymal fat; and vi) altered microbial communities. The collective evidence indicate the potential value of W. confusa WIKIM51 as a functional food supplement for the prevention and amelioration of obesity.
Keywords
Weissella confusa; lactic acid bacteria; anti-obesity activity; Kimchi;
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