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http://dx.doi.org/10.4014/mbl.2001.01015

Neuraminidase-inhibition Activity of Nodakenetin from Gongjin-dan Fermented by Lactic Acid Bacteria  

Seo, Ji Hyun (Science Research Park, LG Household and Healthcare Ltd.)
Park, Dong Jun (Science Research Park, LG Household and Healthcare Ltd.)
Lee, So Young (Science Research Park, LG Household and Healthcare Ltd.)
Cho, Ho Song (Science Research Park, LG Household and Healthcare Ltd.)
Jin, Mu Hyun (Science Research Park, LG Household and Healthcare Ltd.)
Publication Information
Microbiology and Biotechnology Letters / v.48, no.3, 2020 , pp. 303-309 More about this Journal
Abstract
The purpose of this study was to identify the changes in the components of unfermented Gongjin-dan (GD) and fermented Gongjin-dan (FGD) and to confirm whether GD or FGD has an inhibitory effect on viral neuraminidase (NA) activity. A major component of FGD was isolated and identified as nodakenetin, which is the aglycone of nodakenin. After fermentation, the nodakenetin content in FGD was approximately 10-fold higher than that in GD. Then, we examined the viral NA-inhibitory activity of GD, FGD, nodakenin, and nodakenetin. At a concentration of 500 ㎍/ml, FGD inhibited viral NA activity by 92% compared to the DMSO-treated control, while GD barely inhibited viral NA activity. In addition, 250 ㎍/ml of nodakenetin inhibited viral NA activity by 68% compared to the control, while nodakenin inhibited viral NA activity by only 4% at the same concentration as nodakenetin. Collectively, these results suggest that FGD has a more remarkable viral NA-inhibitory activity than GD because the content of the anti-viral component nodakenetin was higher in FGD due to the hydrolysis of nodakenin by Lactobacillus plantarum KCTC 3104.
Keywords
Gongjin-dan; fermentation; Lactobacillus plantarum; nodakenin; nodakenetin; neuraminidase;
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