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http://dx.doi.org/10.4014/mbl.1811.11008

Anti-obesity and Anti-diabetic Effects of the Fermented Ethanol Extracts from White Jelly Fungus (Tremella fuciformis Berk) with Lactobacillus rhamnosus BHN-LAB 76  

Yoon, Yeo-Cho (Institute for Development of Bioindustrial Materials, BHNBIO Co., Ltd.)
Kim, Byung-Hyuk (Institute for Development of Bioindustrial Materials, BHNBIO Co., Ltd.)
Kim, Jung-Gyu (Institute for Development of Bioindustrial Materials, BHNBIO Co., Ltd.)
Lee, Jun-Hyeong (Institute for Development of Bioindustrial Materials, BHNBIO Co., Ltd.)
Park, YeEun (Institute for Development of Bioindustrial Materials, BHNBIO Co., Ltd.)
Park, Hye-Suk (Institute for Development of Bioindustrial Materials, BHNBIO Co., Ltd.)
Hwang, Hak-Soo (Kyochon F&B Co., Ltd.)
Kwon, Gi-Seok (Division of Horticulture & Medicinal Plant, Andong National University)
Lee, Jung-Bok (Institute for Development of Bioindustrial Materials, BHNBIO Co., Ltd.)
Publication Information
Microbiology and Biotechnology Letters / v.47, no.3, 2019 , pp. 323-331 More about this Journal
Abstract
White jelly fungus (Tremella fuciformis Berk; TF) has been used as a traditional medicine in Asia; it is known to prevent hypertension, aging, cancer, and arteriosclerosis. This study aimed to investigate the anti-diabetic effects of fermented Tremella fuciformis Berk (FTF) ethanol extracts fermented with L. rhamnosus BHN-LAB 76. We show that FTF increases the ${\alpha}$-glucosidase inhibitory activity and suppress the adipogenesis of 3T3-L1 adipocytes. These inhibitory effects of FTF are accompanied by the regulation of the phosphorylation of AMPK, JNK, and Akt. These data demonstrate that FTF not only inhibits adipogenesis by affecting the adipogenic signaling, but also increases the anti-diabetic effects by regulating the insulin signaling pathway. Therefore, we suggest that the FTF can be used for developing functional food and cosmetics materials.
Keywords
Anti-obesity activity; anti-diabetic activity; biological activity; lactic acid bacteria; Tremella fuciformis Berk;
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