Plumbagin Inhibits Expression of Virulence Factors and Growth of Helicobacter pylori
![]() |
Lee, Min Ho
(Department of Biomedical Laboratory Science, College of Health Sciences, Yonsei University)
Woo, Hyun Jun (Department of Biomedical Laboratory Science, College of Health Sciences, Yonsei University) Park, Min (Department of Biomedical Laboratory Science, College of Health Sciences, Yonsei University) Moon, Cheol (Department of Clinical Laboratory Science, Semyung University) Eom, Yong-Bin (Department of Biomedical Laboratory Science, College of Medical Sciences, Soonchunhyang University) Kim, Sa-Hyun (Department of Clinical Laboratory Science, Semyung University) Kim, Jong-Bae (Department of Biomedical Laboratory Science, College of Health Sciences, Yonsei University) |
1 | Borin BN, Tang W, Krezel AM. 2014. Helicobacter pylori RNA polymerase alpha-subunit C-terminal domain shows features unique to varepsilon-proteobacteria and binds NikR/DNA complexes. Prot. Sci. 23: 454−463. DOI |
2 | Cover TL, Blanke SR. 2005. Helicobacter pylori VacA, a paradigm for toxin multifunctionality. Nat. Rev. Microbiol. 3: 320−332. DOI |
3 | Cover TL, Blaser MJ. 2009. Helicobacter pylori in health and disease. Gastroenterology 136: 1863−1873. DOI |
4 | Dailidiene D, Tan S, Ogura K, Zhang M, Lee AH, Severinov K, et al. 2007. Urea sensitization caused by separation of Helicobacter pylori RNA polymerase beta and beta' subunits. Helicobacter. 12: 103−111. DOI |
5 | de Paiva SR, Figueiredo MR, Aragao TV, Kaplan MA. 2003. Antimicrobial activity in vitro of plumbagin isolated from Plumbago species. Mem. Inst. Oswaldo. Cruz. 98: 959−961. DOI |
6 | Eldhose B, Gunawan M, Rahman M, Latha MS, Notario V. 2014. Plumbagin reduces human colon cancer cell survival by inducing cell cycle arrest and mitochondria-mediated apoptosis. Int. J. Oncol. 45: 1913−1920. DOI |
7 | Ghotaslou R, Leylabadlo HE, Asl YM. 2015. Prevalence of antibiotic resistance in Helicobacter pylori: A recent literature review. World J. Methodol. 5: 164−174. DOI |
8 | Terradot L, Zawilak-Pawlik A. 2010. Structural insight into Helicobacter pylori DNA replication initiation. Gut. Microbes. 1: 330−334. DOI |
9 | Solnick JV, Hansen LM, Syvanen M. 1997. The major sigma factor (RpoD) from Helicobacter pylori and other gram-negative bacteria shows an enhanced rate of divergence. J. Bacteriol. 179: 6196−6200. DOI |
10 | Stein M, Bagnoli F, Halenbeck R, Rappuoli R, Fantl WJ, Covacci A. 2002. c-Src/Lyn kinases activate Helicobacter pylori CagA through tyrosine phosphorylation of the EPIYA motifs. Mol. Microbiol. 43: 971−980. DOI |
11 | Sunil C, Duraipandiyan V, Agastian P, Ignacimuthu S. 2012. Antidiabetic effect of plumbagin isolated from Plumbago zeylanica L. root and its effect on GLUT4 translocation in streptozotocin-induced diabetic rats. Food Chem. Toxicol. 50: 4356−4363. DOI |
12 | Wang YC, Huang TL. 2005. High-performance liquid chromatography for quantification of plumbagin, an anti-Helicobacter pylori compound of Plumbago zeylanica L. J. Chromatogr A. 1094: 99−104. DOI |
13 | Wiedemann T, Loell E, Mueller S, Stoeckelhuber M, Stolte M, Haas R, Rieder G. 2009. Helicobacter pylori cag-Pathogenicity island-dependent early immunological response triggers later precancerous gastric changes in Mongolian gerbils. PLoS One. 4: e4754. DOI |
14 | Wu IT, Chuah SK, Lee CH, Liang CM, Lu LS, Kuo YH, et al. 2015. Five-year sequential changes in secondary antibiotic resistance of Helicobacter pylori in Taiwan. World J. Gastroenterol. 21: 10669−10674. DOI |
15 | Zhang YX, Zhou LY, Song ZQ, Zhang JZ, He LH, Ding Y. 2015. Primary antibiotic resistance of Helicobacter pylori strains isolated from patients with dyspeptic symptoms in Beijing: a prospective serial study. World J. Gastroenterol. 21: 2786−2792. DOI |
16 | Hatakeyama M. 2004. Oncogenic mechanisms of the Helicobacter pylori CagA protein. Nat. Rev. Cancer. 4: 688−694. DOI |
17 | Khaw AK, Sameni S, Venkatesan S, Kalthur G, Hande MP. 2015. Plumbagin alters telomere dynamics, induces DNA damage and cell death in human brain tumour cells. Mutat. Res. Genet. Toxicol. Environ. Mutagen. 793: 86−95. DOI |
18 | IARC Working Group on the Evaluation of Carcinogenic Risks to Humans. 1994. Schistosomes, liver flukes and Helicobacter pylori. IARC Monogr. Eval. Carcinog. Risks Hum. 61: 1−241. |
19 | Kaewbumrung S, Panichayupakaranant P. 2014. Antibacterial activity of plumbagin derivative-rich Plumbago indica root extracts and chemical stability. Nat. Prod. Res. 28: 835−837. DOI |
20 | Kalali B, Mejias-Luque R, Javaheri A, Gerhard M. 2014. H. pylori virulence factors: influence on immune system and pathology. Mediators Inflamm. 2014: 426309. |
21 | Kim SH, Park M, Woo H, Tharmalingam N, Lee G, Rhee KJ, et al. 2012. Inhibitory effects of anthocyanins on secretion of Helicobacter pylori CagA and VacA toxins. Int. J. Med. Sci. 9: 838−842. DOI |
22 | Kimura M, Ishihama A. 1995. Functional map of the alpha subunit of Escherichia coli RNA polymerase: insertion analysis of the amino-terminal assembly domain. J. Mol. Biol. 248: 756−767. DOI |
23 | Krajewska B. 2009. Ureases I. Functional, catalytic and kinetic properties: A review. J. Mol. Catal B Enzym. 59: 9−21. DOI |
24 | Lee JW, Kim N, Kim JM, Nam RH, Chang H, Kim JY, et al. 2013. Prevalence of primary and secondary antimicrobial resistance of Helicobacter pylori in Korea from 2003 through 2012. Helicobacter. 18: 206−214. DOI |
25 | Lee SW, Kim HJ, Kim JG. 2015. Treatment of Helicobacter pylori Infection in Korea: A Systematic Review and Meta-analysis. J. Korean Med. Sci. 30: 1001−1009. DOI |
26 | Nitharwal RG, Verma V, Dasgupta S, Dhar SK. 2011. Helicobacter pylori chromosomal DNA replication: current status and future perspectives. FEBS Lett. 585: 7−17. DOI |
27 | Li YC, He SM, He ZX, Li M, Yang Y, Pang JX, et al. 2014. Plumbagin induces apoptotic and autophagic cell death through inhibition of the PI3K/Akt/mTOR pathway in human non-small cell lung cancer cells. Cancer Lett. 344: 239−259. DOI |
28 | Mathew R, Chatterji D. 2006. The evolving story of the omega subunit of bacterial RNA polymerase. Trends Microbiol. 14: 450−455. DOI |
29 | Nakayama M, Hisatsune J, Yamasaki E, Isomoto H, Kurazono H, Hatakeyama M, et al. 2009. Helicobacter pylori VacA-induced inhibition of GSK3 through the PI3K/Akt signaling pathway. J. Biol. Chem. 284: 1612−1619. DOI |
30 | Odenbreit S, Puls J, Sedlmaier B, Gerland E, Fischer W, Haas R. 2000. Translocation of Helicobacter pylori CagA into gastric epithelial cells by type IV secretion. Science 287: 1497−1500. DOI |
31 | Bornschein J, Malfertheiner P. 2014. Helicobacter pylori and gastric cancer. Dig. Dis. 32: 249−264. DOI |
32 | Padhye S, Dandawate P, Yusufi M, Ahmad A, Sarkar FH. 2012. Perspectives on medicinal properties of plumbagin and its analogs. Med. Res. Rev. 32: 1131−1158. DOI |
33 | Park BS, Lee HK, Lee SE, Piao XL, Takeoka GR, Wong RY, et al. 2006. Antibacterial activity of Tabebuia impetiginosa Martius ex DC (Taheebo) against Helicobacter pylori. J. Ethnopharmacol. 105: 255−262. DOI |
34 | Saadat I, Higashi H, Obuse C, Umeda M, Murata-Kamiya N, Saito Y, et al. 2007. Helicobacter pylori CagA targets PAR1/MARK kinase to disrupt epithelial cell polarity. Nature 447: 330−333. DOI |
35 | Smolka AJ, Backert S. 2012. How Helicobacter pylori infection controls gastric acid secretion. J. Gastroenterol. 47: 609−618. DOI |
![]() |