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http://dx.doi.org/10.4014/mbl.1502.02003

In-vitro Anti-thrombosis Activity of R4-Nuruk Made from Rhizopus oryzae KSD-815  

Kim, Mi-Sun (Department of Food and Nutrition)
Lee, Ye-Seul (Department of Food and Nutrition)
Kim, Jong Sik (Department of Life Science, Andong National University)
Shin, Woo-Chang (Research Institute, Kooksoondang Brewery Co. Ltd.)
Sohn, Ho-Yong (Department of Food and Nutrition)
Publication Information
Microbiology and Biotechnology Letters / v.43, no.2, 2015 , pp. 169-174 More about this Journal
Abstract
Nuruk has been used as fermentation starter in the alcohol industry for some time in Korea. Various bioactivities, such as antiproliferative and anti-obesity, of R4 nuruk made from Rhizopus oryzae KSD-815 have been previously reported. In this study, the hot water and ethanol extract of R4 nuruk and their subsequent organic solvent fractions were prepared, and their antithrombosis activities were evaluated. The ethylacetate fraction showed strong anti-coagulation activity, and the ethylacetate and butanol fraction from hot water extract demonstrated platelet aggregation inhibitory activity, without hemolysis against human RBC. Our results suggest that R4 nuruk has the potential to act as a new anti-thrombosis agent.
Keywords
Anti-coagulation; anti-platelet aggregation; Rhizopus oryzae KSD-815; R4 nuruk;
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Times Cited By KSCI : 17  (Citation Analysis)
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