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http://dx.doi.org/10.4014/mbl.1502.02001

Red Ginseng Ethanol Extract Suppressed Ag I/II-induced Up-expression of Inflammatory Mediators in RAW 264.7 Macrophages  

Choi, Kyung-Min (Department of Research Development, Institute of Jinan Red Ginseng)
Hwang, Seung-Mi (Department of Research Development, Institute of Jinan Red Ginseng)
Lim, Ji-Ye (Department of Research Development, Institute of Jinan Red Ginseng)
Ko, Eun-Sil (Department of Research Development, Institute of Jinan Red Ginseng)
Park, Jong-Hyuk (Imsil Research Institute of Cheese Science)
Moon, Jung-Hye (Imsil Research Institute of Cheese Science)
Lee, Min-Jung (Berry&Bio Food Research Institute)
Jang, Ji-Eun (Berry&Bio Food Research Institute)
Cha, Jeong-Dan (Department of Research Development, Institute of Jinan Red Ginseng)
Publication Information
Microbiology and Biotechnology Letters / v.43, no.2, 2015 , pp. 158-163 More about this Journal
Abstract
In this study, we investigated the effects of 40% ethanol extract of Red Ginseng (RGE) on the productions of inflammatory proteins in Antigen I/II (Ag I/II)-N, a recombinant protein isolated from Streptococcus mutans -stimulated in RAW 264.7 cells. RGE inhibited the expression of Ag I/II-N-induced pro-inflammatory mediators, both mRNA and protein synthesis levels, without any cytotoxic effects. Moreover, RGE significantly inhibited Ag I/II-N induced NF-κB translocation into the nucleus by preventing the degradation of inhibitor κB-α. In conclusion, RGE down regulates the expression of pro-inflammatory genes involved in the synthesis of NO and iNOS in Ag I/II-N-stimulated RAW 264.7 cells by suppressing NF-κB activity.
Keywords
Panax ginseng; red ginseng; ginsenosides; anti-inflammation; inflammatory mediators; cytokines;
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