Anti-inflammatory Effect of Sargassum coreanum Ethanolic Extract through Suppression of NF-κB Pathway in LPS Induced RAW264.7 Cells in Mice
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Kang, Bo-Kyeong
(Department of Food Science & Technology/Institute of Food Science, Pukyong National University)
Kim, Koth-Bong-Woo-Ri (Institute of Fisheries Sciences, Pukyong National University) Kim, Min-Ji (Institute of Fisheries Sciences, Pukyong National University) Bark, Si-Woo (Department of Food Science & Technology/Institute of Food Science, Pukyong National University) Pak, Won-Min (Department of Food Science & Technology/Institute of Food Science, Pukyong National University) Ahn, Na-Kyung (Department of Food Science & Technology/Institute of Food Science, Pukyong National University) Choi, Yeon-Uk (Department of Food Science & Technology/Institute of Food Science, Pukyong National University) Bae, Nan-Young (Department of Food Science & Technology/Institute of Food Science, Pukyong National University) Park, Ji-Hye (Department of Food Science & Technology/Institute of Food Science, Pukyong National University) Ahn, Dong-Hyun (Department of Food Science & Technology/Institute of Food Science, Pukyong National University) |
1 | Moon JH, Go H, Shin SM, Kim KT. 2013. Anti-inflammatory effect of extracts from Ligustrum obtusifolium S. Fruits in RAW 264.7 macrophages. J. Soc. Korean Med. Diagn. 17: 263-273. |
2 | See JH, Kim ND, Choi JS, Kim YJ, Moon YH, Lim SY, et al. 1998. Inhibitory effects of the methanolic extract of an edible brown alga, Ecklonia stolonifera and its component, phloroglucino on aflatoxin B1 mutagenicity in vitro (Ames test) and on benzo(a)pyrene or N-methyl N-nitrosourea clastogenicity in vivo (mouse micronucleus test). Nat. Prod. Sci. 4: 105-114. |
3 | World Health Organization: Research guidelines for evaluating the safety and efficacy of herbal medicine. 1992. Regional Office for Western Pacific, Manila, Philiphines pp. 1-38. |
4 | Yun HY, Dawson VL, Dawson TM. 1996. Neurobiology of nitric oxide. Crit. Rev. Neurobiol. 10: 291-316. DOI |
5 | Lee TH, Kwak HB, Kim HH, Lee ZH, Chung DK, Baek NI, et al. 2007. Methanol extracts of Stewartia koreana inhibit cyclo-oxygenase-2(COX-2) and inducible nitric oxide synthase(iNOS) gene expression by blocking NF-kappaB trans activation in LPS-activated RAW 264.7 cells. Mol. Cells. 23: 398-404. |
6 | Lim HR, Shin SW. 2010. Effects of the essential oil components from Ligusticum chuanxiong on proinflammatory mediators of RAW264.7 macrophage cells. Korean Sci. Pharm. 16: 259-264. |
7 | Masters SL, Simon A, Aksentijevich I, Kastner DL. 2009. Horror auto-inflammaticus: the molecular pathophysiology of autoinflammatory disease. Ann. Rev. Immunol. 27: 621-668. DOI ScienceOn |
8 | McDaniel ML, Kwon G, Hill JR, Marshall CA, Corbett JA. 1996. Cytokines and nitric oxides in islet inflammation and diabetes. Proc. Soc. Exp. Biol. Med. 211: 24-32. DOI |
9 | Majdalawieh A, Ro HS. 2010. Regulation of IκBα function and NF-κB signaling: AEBP1 is a novel proinflammatory mediator in macrophages. Mediators Inflamm. 2010: 823-821. |
10 | Nagayama K, Iwamura Y, Shibata T, Hirayama I, Nakamura T. 2002. Bactericidal activity of phlorotannins from the brown alga Ecklonia Kurome. J. Antimicrob. Chemother. 50: 889-893. DOI |
11 | Nathan C. 1992. Nitric oxide as a secretory product of mammalian cells. FASEB J. 6: 3051-3064. DOI |
12 | Park SG, Jegal KH, Jung JY, Back YD, Byun SH, Kim YW, et al. 2014. Leonuri fructus ameliorates acute inflammation via the inhibition of NF-κB-mediated nitric oxide and pro-inflammatory cytokine production. Korean J. Orient. Physiol. Pathol. 28: 178-185. |
13 | Hahn DH, Sur BJ, Han DO, Park JH, Jung ET, Lee HJ, et al. 2008. Anti-inflammatory activity of dandelion in mice. Korean J. Ori. Med. Physiol. Phthol. 22: 810-814. |
14 | Duerksen-Hughes PJ, Day D, Laster SM, Zacharidase NA, Aquino L, Gooding LR. 1992. Both tumor necrosis factor and nitric oxide participate in lysis of simian virus 40-transformed cells by activated macrophages. J. Immuno. 149: 2-14. |
15 | Ghosh S, Hayden HS. 2008. New regulators of NF-κB in inflammation. Nat. Rev. Immunol. 8: 837-848. DOI |
16 | Halliwell B, Gutteridge JMC. 1999. Antioxidant defenses. In Free radicals in Biology and Medicine. 3rd ed. Oxford Science Publications, Oxford, UK. pp. 105-159. |
17 | Lee ST, Jeong YR, Ha MH, Kim SH, Byun MW, Jo SK. 2000. Induction of nitric oxide and TNF-α by herbal plant extract in mouse macrophage. J. Korean Soc. Food Sci. Nutr. 29: 342-348. |
18 | Jeong JB, Hong SC, Jeong HJ, Koo JS. 2012. Anti-inflammatory effects of ethyl acetate fraction from Cnidium officinale Makino on LPS-stimulated RAW 264.7 and THP-1 cells. Korean J. Plant Res. 25: 299-307. DOI |
19 | Kim DH, Park SJ, Jung JY, Kim SC, Byun SH. 2009. Anti-inflammatory effects of the aqueous extract of Hwangnyenhaedoktang in LPS-activated macrophage cells. Korean J. Herbol. 24: 39-47. |
20 | Kim HS, Kim GJ. 1998. Effects of the feeding Hizikia fusiforme(Harvey) Okamura on lipid composition of serum in dietary hyperlipidemic rats. J. Korean Soc. Food Sci. Nutr. 27: 718-723. |
21 | Ljung T, Lundberg S, Varsanyi M, Ohansson C, Schmidt PT, Herulf M, et al. 2006. Rectal nitric oxide as biomaker in the treatment of inflammatory bowel disease: responders versus non-responders. World Gastroenterol. 12: 3386-3392. DOI |
22 | Bishop-Bailey D, Calatayud S, Warner TD, Hla T, Mitchell JA. 2002. Prostaglandins and the regulation of tumor growth. J. Environ. Pathol. Tox. Oncol. 21: 93-101. |
23 | Celec P. 2004. Nuclear factor kappa B-molecular biomedicine: the next generation. Biomed. Pharmacother. 58: 365-371. DOI |
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