Bioconversion of Ginsenoside Rb1 to the Pharmaceutical Ginsenoside Compound K using Aspergillus usamii KCTC 6954 |
Jo, Mi Na
(Department of Food Science and Biotechnology of Animal Resources, Konkuk University)
Jung, Ji En (Department of Food Science and Biotechnology of Animal Resources, Konkuk University) Yoon, Hyun Joo (Department of Food Science and Biotechnology of Animal Resources, Konkuk University) Chang, Kyung Hoon (Food R&D, CJ Cheiljedang Corp.) Jee, Hee Sook (Ilhwa Co., Ltd.) Kim, Kee-Tae (Bio/Molecular Informatics Center, Konkuk University) Paik, Hyun-Dong (Department of Food Science and Biotechnology of Animal Resources, Konkuk University) |
1 | Barbagallo RN, Spagna G, Palmeri R, Restuccia C, Giudici P. 2004. Selection, characterization and comparison of -glucosidase from mould and yeasts employable for enological applications. Enzyme Microb. Technol. 35: 58-66. DOI |
2 | Chang KH, Jee HS, Lee NK, Park SH, Lee NW, Paik HD. 2009. Optimization of the enzymatic production of 20(S)-ginsenoside Rg3 from white ginseng extract using response surface methodology. New Biotechnol. 26: 181-186. DOI ScienceOn |
3 | Chang KH, Jo MN, Kim KT, Paik HD. 2012. Purification and characterization of a ginsenoside Rb1-hydrolyzing -glucosidase from Aspergillus niger KCCM 11239. Int. J. Mol. Sci. 13: 12140-12152. DOI |
4 | Choi JE, Nam KY, Li X, Kim BY, Cho HS, Hwang KB. 2010. Change of chemical components and ginsenoside contents of different root parts of ginsengs with processing method. Korean J. Med. Crop Sci. 18: 118-125. |
5 | Cui CH, Kim SC, Im WT. 2013. Characterization of the ginsenoside-transforming recombinant beta-glucosidase from Actinosynnema mirum and bioconversion of major ginsenosides into minor ginsenosides. Appl. Microbiol. Biotechnol. 97: 649-659. DOI ScienceOn |
6 | Fuzzati, N. 2004. Analysis methods of ginsenosides. J. Chromatogr. B 812: 119-133. DOI |
7 | Hongwei L, Xin L, Xiaohui Q, Ying H, Dacheng H, Yu C, et al. 2006. Purification and characterization of novel stable ginsenoside Rb1-hydrolyzing -glucosidase from China white jade snail. Process Biochem. 41:1974-1980. DOI ScienceOn |
8 | In JG, Lee BS, Kim EJ, Park MH, Yang DC. 2006. Increase of functional saponin by acid treatment and temperature of red ginseng extract. Korean J. Plant Res. 19: 139-143. |
9 | Kim JW, Doo HS, Kwon TH, Kim YS, Shin DH. 2011. Quality characteristics of Doenjang Meju fermentation with Aspergillus species and Bacillus subtilis during fermentation. Korean J. Food Preserv. 18: 397-406. DOI ScienceOn |
10 | Kim SK, Kwak YS, Kim SW, Hwang SY, Ko YS, Yoo CM. 1998. Improved method for the preparation of crude ginseng saponin. J. Ginseng Res. 22: 155-160. |
11 | Kim WY, Kim JM, Han SB, Lee SK, Kim ND, Park MK. 2000. Steaming of ginseng at high temperature enhances biological activity. J. Nat. Prod. 63: 1702-1704. DOI ScienceOn |
12 | Lim SI, Cho CW, Choi UK, Kim YC. 2010. Antioxidant activity and ginsenoside pattern of fermented white ginseng. J. Ginseng Res. 34: 168-174. DOI ScienceOn |
13 | Liu L, Gu LJ, Zhang DL, Wang Z, Wang CY, Li Z, et al. 2010. Microbial conversion of rare ginsenoside to 20(S)-protopanaxatriol by Aspergillus niger. Biosci. Biotechnol. Biochem. 74: 96-100. DOI ScienceOn |
14 | Lu J, Weerasiri RR, Liu Y, Wang W, Ji S, Lee I. 2013. Enzyme production by the mixed fungal culture with nano-shear pretreated biomass and lignocellulose hydrolysis. Biotechnol. Bioeng. 110: 2123-2130. DOI |
15 | Park D, Bae DW, Jeon JH, Lee J, Oh N, Yang G, et al. 2011. Immunopotentiation and antitumor effects of a ginsenoside -fortified red ginseng preparation in mice bearing H460 lung cancer cells. Environ. Toxicol. Pharm. 31: 397-405. DOI ScienceOn |
16 | Park HJ, Jung DH, Joo H, Kang NS, Jang SA, Lee JG, et al. 2010. The comparative study of anti-allergic and anti-inflammatory effects by fermented red ginseng and red ginseng. Korean J. Plant Res. 23: 415-422. |
17 | Pyo YH, Lee TC, Lee YC. 2005. Enrichment of bioactive isoflavones in soymilk fermented with -glucosidase-producing lactic acid bacteria. Food Res. Int. 38: 551-559. DOI ScienceOn |
18 | So JH, Do HJ, Rhee IK. 2010. Purification and characterization of -glucosidase from Aspergillus usamii D5 capable of hydrolyzing isoflavone glycosides in soybean and astragali radix. J. Korean Soc. Appl. Biol. Chem. 53: 626-633. DOI |
19 | Ryu JS, Lee HJ, Bae SH, Kim SY, Park Y, Suh HJ, et al. 2013. The bioavailability of red ginseng extract fermented by Phellinus linteus. J. Ginseng Res. 37: 108-16. DOI ScienceOn |
20 | Shi H, Yin X, Wu M, Tang C, Zhang H, Li J. 2012. Cloning and bioinformatics analysis of an endoglucanase gene (Aucel12A) from Aspergillus usamii and its functional expression in Pichia pastoris. J. Ind. Microbiol. Biotechnol. 39: 347-357. DOI |
21 | Singhania RR, Sukumaran RK, Rajasree KP, Mathew A, Gottumukkala L, Pandey A. 2011. Properties of a major -glucosidase-BGL1 from Aspergillus niger NII-08121 expressed differentially in response to carbon sources. Process Biochem. 46: 1521-1524. DOI |
22 | Wang YT, Li XW, Jin HY, Yu Y, You JY. 2007. Degradation of ginsenosides in root of Panax ginseng C. A. Mey. by highpressure microwave-assisted extraction. Chem. J. Chin. Univ. 28: 2264-2269. |
23 | Xu LL, Han T, Wu JZ, Zhang QY, Zhang H, Huang BK, et al. 2009. Comparative research of chemical constituents, antifungal and antitumor properties of ether extracts of Panax ginseng and its endophytic fungus. Phytomedicine 16: 609-616. DOI ScienceOn |
24 | Zhang C, Li D, Yu H, Zhang B, Jin F. 2007. Purification and characterization of piceid--glucosidase from Aspergillus oryzae. Process Biochem. 42: 83-88. DOI |
25 | Yu H, Liu Q, Zhang C, Lu M, Fu Y, Im WT, et al. 2009. A new ginsenosidase from Aspergillus strain hydrolyzing 20-O-multi glycoside of PPD ginsenoside. Process Biochem. 44: 772-775. DOI ScienceOn |
26 | Li WK, Gu CG, Zhang HJ, Awang DVC, Fitzloff JF, Fong HHS, et al. 2000. Use of high performance liquid chromatography tandem mass spectrometry to distinguish Panax ginseng C.A Meyer (Asian ginseng) and Panax quinquefolius. L. (America ginseng). Anal. Chem. 72: 5417-5422. DOI ScienceOn |
27 | Liu L, Zhu XM, Wang QJ, Zhang DL, Fang ZM, Wang CY, et al. 2010. Enzymatic preparation of 20(S, R)-protopanaxadiol by transformation of 20(S, R)-Rg3 from black ginseng. Phytochemistry 71: 1514-1520. DOI ScienceOn |
28 | Sua JH, Xua JH, Lu WY, Lin GQ. 2006. Enzymatic transformation of ginsenoside to using newly isolated Fusarium proliferatum ECU2042. J. Mol. Catal. B-enzyme 38: 113-118. |