Browse > Article
http://dx.doi.org/10.4014/kjmb.1311.11006

Antibacterial Activity Evaluation of Radioisotope Lu-177 with a Modified Tube on Plate Core  

Joh, Eun-Ha (Radioisotope Research Division, Department of Research Reactor Utilization, Korea Atomic Energy Research Institute)
Publication Information
Microbiology and Biotechnology Letters / v.41, no.4, 2013 , pp. 469-471 More about this Journal
Abstract
In this study, we measured the anti-bacterial activity of radioisotope Lu-177 using a new laboratory instrument. The disk method used for the measurement of existing anti-bacterial antibiotics is drug diffusion into the medium. To measure the antimicrobial activity of a radioisotope, a new type of laboratory instrument is necessary to prevent the drug from spreading and the present invention was thus tested. In the medium, a space isolated separately for radioisotope injection was used to prevent the radioisotope from spreading and radioisotopes are actually injected by this system. We found that the antibacterial activity increased according to the radiation dose increases. It is expected that, through the present study, measuring the antibacterial activity of the other radioisotopes easily in the laboratory will be possible.
Keywords
Radioisotope; antibacterial; lutetium-177;
Citations & Related Records
연도 인용수 순위
  • Reference
1 Huclier-Markai S, Alliot C, Varmenot N, Cutler CS, Barbet J. 2012. Alpha-emitters for immuno-therapy: a review of recent developments from chemistry to clinics. Curr. Top. Med. Chem. 12: 2642-2654.
2 Hueting R, Tavare R, Dilworth JR, Mullen GE. 2013. Copper-64 radiolabelling of the C2A domain of synaptotagmin I using a functionalised bis(thiosemicarbazone): A pre- and postlabelling comparison. J. Inorg. Biochem. 128: 108-111.   DOI   ScienceOn
3 Kang CS, Sun X, Jia F, Song HA, Chen Y, Lewis M, et al. 2012. Synthesis and preclinical evaluation of bifunctional ligands for improved chelation chemistry of 90Y and 177Lu for targeted radioimmunotherapy. Bioconjug. Chem. 23: 1775-1782.   DOI   ScienceOn
4 Otani Y, Yamada T, Kato S, Shikama N, Funakoshi K, Kuroda I, et al. 2013. Source strength assay of iodine-125 seeds sealed within sterile packaging. J. Appl. Clin. Med. Phys. 14: 4082.
5 Somily AM. 2010. Comparison of E-test and disc diffusion methods for the in vitro evaluation of the antimicrobial activity of colistin in multi-drug resistant Gram-negative Bacilli. Saudi. Med. J. 31: 507-511.
6 Towers S. 2013. Improving the control of systematic uncertainties in precision measurements of radionuclide half-life. Appl. Radiat. Isot. 77: 110-114.   DOI   ScienceOn
7 Ujjani C, Cheson BD. 2013. The current status and future impact of targeted therapies in non-Hodgkin lymphoma. Expert. Rev. Hematol. 6: 191-202.   DOI   ScienceOn
8 Vera DR, Eigner S, Henke KE, Lebeda O, Melichar F, Beran M. 2012. Preparation and preclinical evaluation of $^{177}Lu$-nimotuzumab targeting epidermal growth factor receptor overexpressing tumors. Nucl. Med. Biol. 39: 3-13.   DOI   ScienceOn
9 Yong KJ, Milenic DE, Baidoo KE, Brechbiel MW. 2013. Sensitization of tumor to $^{212}Pb$ radioimmunotherapy by gemcitabine involves initial abrogation of G2 arrest and blocked DNA damage repair by interference with Rad51. Int. J. Radiat. Oncol. Biol. Phys. 85: 1119-1126.   DOI   ScienceOn
10 Abedi D, Feizizadeh S, Akbari V, Jafarian-Dehkordi A. 2013. In vitro anti-bacterial and anti-adherence effects of Lactobacillus delbrueckii subsp bulgaricus on Escherichia coli. Res. Pharm. Sci. 8: 260-268.
11 Bryan RA, Guimaraes AJ, Hopcraft S, Jiang Z, Bonilla K, Morgenstern A, et al. 2012. Toward developing a universal treatment for fungal disease using radioimmunotherapy targeting common fungal antigens. Mycopathologia. 173: 463-471.   DOI   ScienceOn
12 De Guzman ZM, Cervancia CR, Dimasuay KG, Tolentino MM, Abrera GB, Cobar ML, et al. 2011. Radiation inactivation of Paenibacillus larvae and sterilization of American Foul Brood (AFB) infected hives using Co-60 gamma rays. Appl. Radiat. Isot. 69: 1374-1379.   DOI   ScienceOn
13 Jeon YH, Lee HW, Lee YL, Kim JE, Hwang MH, Jeong SY, et al. 2011. Combined E7-dendritic cell-based immunotherapy and human sodium/iodide symporter radioiodine gene therapy with monitoring of antitumor effects by bioluminescent imaging in a mouse model of uterine cervical cancer. Cancer. Biother. Radiopharm. 26: 671-679.   DOI   ScienceOn