Browse > Article

Antimicrobial Effects and Mechanism(s) of Silver Nanoparticle  

Hwang, In-Sok (School of Life Sciences and Biotechnology, College of Natural Sciences, Kyungpook National University)
Cho, Jae-Yong (School of Life Sciences and Biotechnology, College of Natural Sciences, Kyungpook National University)
Hwang, Ji-Hong (School of Life Sciences and Biotechnology, College of Natural Sciences, Kyungpook National University)
Hwang, Bo-Mi (School of Life Sciences and Biotechnology, College of Natural Sciences, Kyungpook National University)
Choi, Hye-Min (School of Life Sciences and Biotechnology, College of Natural Sciences, Kyungpook National University)
Lee, June-Young (School of Life Sciences and Biotechnology, College of Natural Sciences, Kyungpook National University)
Lee, Dong-Gun (School of Life Sciences and Biotechnology, College of Natural Sciences, Kyungpook National University)
Publication Information
Microbiology and Biotechnology Letters / v.39, no.1, 2011 , pp. 1-8 More about this Journal
Abstract
The antimicrobial effects of silver (Ag) ion or salts are well known. Recently, silver nanoparticle is attracting an interest in a wide variety of fields since it has been known to be safe and effective as an antimicrobial agent against a broad spectrum of microorganisms. Although silver nanoparticle has been applied to various kinds of products owing to its potent antimicrobial activity, the effects of silver nanoparticle on microorganisms and antimicrobial mechanism have not been revealed clearly. In this paper, we summarized the characteristics, antimicrobial activities and mechanisms, cytotoxicity and applicability of silver nanoparticle.
Keywords
Silver nanoparticle; antimicrobial activity; antimicrobial mechanism;
Citations & Related Records
Times Cited By KSCI : 2  (Citation Analysis)
Times Cited By SCOPUS : 0
연도 인용수 순위
1 Ravelin, J. 1869. Chemistry of vegetation. Sci. Nat. 11: 93-102.
2 Roh, J. Y. et al. 2009. Ecotoxicity of silver nanoparticles on the soil nematode Caenorhabditis elegans using functional ecotoxicogenomics. Environ. Sci. Technol. 43: 3933-3940.   DOI   ScienceOn
3 Sekhon, B. S. and S. R. Kamboj. 2010. Inorganic nanomedicine-part 2. Nanomedicine 6: 612-618.   DOI   ScienceOn
4 Shahverdi, A. R. et al. 2007. Rapid synthesis of silver nanoparticles using culture supernatants of Enterobacteria: a novel biological approach. Process Biochem. 42: 919-923.   DOI   ScienceOn
5 Shahverdi, A. R., A. Fakhimi, H. R. Shahverdi, and S. Minaian. 2007. Synthesis and effect of silver nanoparticles on the antibacterial activity of different antibiotics against Staphylococcus aureus and Escherichia coli. Nanomedicine 3: 168-171.   DOI   ScienceOn
6 Shaligram, N. S. et al. 2009. Biosynthesis of silver nanoparticles using aqueous extract from the compactin producing fungal strain. Process Biochem. 44: 939-943.   DOI   ScienceOn
7 Shrivastava, S. 2007. Characterization of enhanced antibacterial effects of novel silver nanoparticles. Nanotechnology 18: 225103-225112.   DOI   ScienceOn
8 Sondi, I. and B. S. Sondi. 2004. Silver nanoparticles as antimicrobial agent: a case study on E. coli as a model for Gram-negative bacteria. J. Colloid Interface Sci. 275: 177-182.   DOI   ScienceOn
9 Tian, J., K. K. Wong, C. M. Ho, C. N. Lok, W. Y. Yu, C. M. Che, J. F. Chiu, and P. K. Tam. 2007. Topical delivery of silver nanoparticles promotes wound healing. Chem. Med. Chem. 2: 129-136.   DOI
10 Lu, Y., G. L. Liu, and L. P. Lee. 2005. High-density silver nanoparticle film with temperature-controllable interparticle spacing for a tunable surface enhanced Raman scattering substrate. Nano. Lett. 5: 5-9.   DOI   ScienceOn
11 Morones, J. R., J. L. Elechiguerra, A. Camacho, K. Holt, J. B. Kouri, J. T. Ramirez, and M. J. Yacaman. 2005. The bactericidal effect of silver nanoparticles. Nanotechnology 16: 2345-2353.
12 Nanda, A. and M. Saravanan. 2009. Biosynthesis of silver nanoparticles from Staphylococcus aureus and its antimicrobial activity against MRSA and MRSE. Nanomedicine 5: 452-456.   DOI   ScienceOn
13 Pal, S., Y. K. Tak, and J. M. Song. 2007. Does the antibacterial activity of silver nanoparticles depend on the shape of the nanoparticle? A study of the Gram-negative bacterium Escherichia coli. Apple. Environ. Microbiol. 73: 1712-1720.   DOI   ScienceOn
14 Kokura, S., O. Handa, T. Takagi, T. Ishikawa, Y. Naito, and T. Yoshikawa. 2010. Silver nanoparticles as a safe preservative for use in cosmetics. Nanomedicine 6: 570-574.   DOI   ScienceOn
15 Park, H. J., J. Y. Kim, J. Kim, J. H. Lee, J. S. Hahn, M. B. Gu, and J. Yoon. 2009. Silver-ion-mediated reactive oxygen species generation affecting bactericidal activity. Water Res. 43: 1027-1032.   DOI   ScienceOn
16 Pedahzur, R., H. I. Shuval, and S. Ulitzur. 1997. Silver and hydrogen peroxide as potential drinking water disinfectants: Their bactericidal effects and possible modes of action. Water Sci. Technol. 35: 87-93.
17 Pedahzur, R., O. Lev, B. Fattal, and H. I. Shuval. 1995. The interaction of silver ions and hydrogen peroxide in the inactivation of E. coli: a preliminary evaluation of a new long acting residual drinking water disinfectant. Water Sci. Technol. 31: 123-129.
18 Kora, A. J. et al. 2009. Superior bactericidal activity of SDS capped silver nanoparticles: synthesis and characterization. Mater. Sci. Eng. C. 29: 2104-2109.   DOI   ScienceOn
19 Kumar, A., P. K. Vemula, P. M. Ajayan, and G. John. 2008. Silver-nanoparticle-embedded antimicrobial paints based on vegetable oil. Nat. Mater. 7: 236-241.   DOI   ScienceOn
20 Landeen, L. K., M. T. Yahya, and C. P. Gerba. 1989. Efficacy of copper and silver ions and reduced levels of free chlorine in inactivation of Legionella pneumophila. Appl. Environ. Microbiol. 55: 3045-3050.
21 Lara, H. H., N. V. Ayala-Nuñez, L. Ixtepan-Turrent, and C. Rodriguez-Padilla. 2010. Mode of antiviral action of silver nanoparticles against HIV-1. J. Nanobiotechnology 8: 1.   DOI   ScienceOn
22 Izatt, R. M., J. J. Christensen, and J. H. Rytting. 1971. Sites and thermodynamic quantities associated with proton and metal ion interaction with ribonucleic acid, deoxyribonucleic acid, and their constituent bases, nucleosides, and nucleotides. Chem. Rev. 71: 439-481.   DOI   ScienceOn
23 Liau, S. Y., D. C. Read, W. J. Pugh, J. R. Furr, and A. D. Russell. 1997. Interaction of silver-nitrate with readily identifiable groups: relationship to the antibacterial action of silver ions. Lett. Appl. Microbiol. 25: 279-283.   DOI   ScienceOn
24 Li, P., J. Li, C. Wu, Q. Wu, and J. Li. 2005. Synergistic antibacterial effects of β-lactam antibiotic combined with silver nanoparticles. Nanotechnology 16: 1912-1917.   DOI   ScienceOn
25 Lok, C. N. et al. 2007. Silver nanoparticles: partial oxidation and antibacterial activities. J. Biol. Inorg. Chem. 12: 527- 534.   DOI   ScienceOn
26 Jain, P. and T. Pradeep. 2005. Potential of silver nanoparticle -coated polyurethane foam as an antibacterial water filter. Biotechnol. Bioeng. 90: 59-63.   DOI   ScienceOn
27 Jung, W. K. et al. 2008. Antibacterial activity and mechanism of action of the silver ion in Staphylococcus aureus and Escherichia coli. Appl. Environ. Microbiol. 74: 2171?2178.   DOI   ScienceOn
28 Kalishwaralal, K., S. Barathmanikanth, S. R. K. Pandian, V. Deepak, and S. Gurunathan. 2010. Silver nanoparticles impede the biofilm formation by Pseudomonas aeruginosa and Staphylococcus epidermidis. Colloids and Surfaces B. 79: 340-344.   DOI   ScienceOn
29 Kim, J. Y., C. Lee, M. Cho, and J. Yoon. 2008. Enhanced inactivation of E. coli and MS-2 phage by silver ions combined with UV-A and visible light irradiation. Water Res. 42: 356-362.   DOI   ScienceOn
30 Kim, J. S., E. Kuk, K. N. Yu, J. H. Kim, S. J. Park, H. J. Lee, S. H. Kim, Y. K. Park, Y. H. Park, C. Y. Hwang, Y. K. Kim, Y. S. Lee, D. H. Jeong, and M. H. Cho. 2007. Antimicrobial effects of silver nanoparticles. Nanomedicine 3: 95-101.   DOI   ScienceOn
31 Kim, J. Y., T. Y. Kim, and J. Y. Yoon. 2009. Antimicrobial Activity and Mechanism of Silver. J. Korean Ind. Eng. Chem. 20: 251-257.
32 Kim, K. J., W. S. Sung, B. K. Suh, S. K. Moon, J. S. Choi, J. G. Kim, and D. G. Lee. 2009. Antifungal activity and mode of action of silver nano-particles on Candida albicans. Biometals. 22: 235-242.   DOI   ScienceOn
33 Kim, K. J., W. S. Sung, S. K. Moon, J. S. Choi, J. G. Kim, and D. G. Lee. 2008. Antifungal effect of silver nanoparticles on dermatophytes. J. Microbiol. Biotechnol. 18: 1482-1484.
34 Davis, R. L. and S. F. Etris. 1997. The development and functions of silver in water purification and disease control. Catalysis Today. 36: 107.   DOI   ScienceOn
35 Fayaz, A. M., K. Balaji, M. Girilal, R. Yadav, P. T. Kalaichelvan, and R. Venketesan. 2010. Biogenic synthesis of silver nanoparticles and their synergistic effect with antibiotics: a study against gram-positive and gram-negative bacteria. Nanomedicine 6: 103-109.   DOI   ScienceOn
36 Feng, Q. L, J. Wu, G. Q. Chen, F. Z. Cui, T. N. Kim, and J. O. Kim. 2000. A mechanistic study of the antibacterial effect of silver ions on Escherichia coli and Staphylococcus aureus. J. Biomed. Mater. Res. 52: 662-668.   DOI   ScienceOn
37 Gajbhiye, M., J. Kesharwani, A. Ingle, A. Gade, and M. Rai. 2009. Fungus-mediated synthesis of silver nanoparticles and their activity against pathogenic fungi in combination with fluconazole. Nanomedicine 5: 382-386.   DOI   ScienceOn
38 Greenfeld, J. I., L. Sampath, S. J. Popilskis, S. R. Brunnert, S. Stylianos, and S. Modak. 1995. Decreased bacterial adherence and biofilm formation on chlorhexidine and silver sulfadiazine-impregnated central venous catheters implanted in swine. Crit. Care Med. 23: 894-900.   DOI   ScienceOn
39 Gogoi, S. K., P. Gopinath, A. Paul, A. Ramesh, S. S. Ghosh, and A. Chattopadhyay. 2006. Green fluorescent proteinexpressing Escherichia coli as a model system for investigating the antimicrobial activities of silver nano-particles. Langmuir 22: 9322-9328.   DOI   ScienceOn
40 Graf, P. et al. 2009. Peptide-coated silver nanoparticles: synthesis, surface chemistry, and pH-triggered, reversible assembly into particle assemblies. Chemistry 15: 5831-5844.   DOI   ScienceOn
41 Gutierrez, F. M., P. L. Olive, A. Banuelos, E. Orrantia, N. Nino, E. M. Sanchez, F. Ruiz, H. Bach, and Y. A. Gay. 2010. Synthesis, characterization, and evaluation of antimicrobial and cytotoxic effect of silver and titanium nanoparticles. Nanomedicine 6: 681-688.   DOI   ScienceOn
42 Holt, K. B. and A. J. Bard. 2005. The Interaction of Silver (I) Ions with the Respiratory Chain of Escherichia coli: An Electrochemical and Scanning Electrochemical Microscopy Study of the Antimicrobial Mechanism of Micromolar $Ag^{+}$. Biochemistry 44: 13214-13223.   DOI   ScienceOn
43 Imran, M., A. M. Revol-Junelles, A. Martyn, E. A. Tehrany, M. Jacquot, M. Linder, and S. Desobry. 2010. Active food packaging evolution: transformation from micro- to nanotechnology. Food. Science and Nutrition 50: 799-821.
44 Carlson, C. et al. 2008. Unique cellular interaction of silver nanoparticles: size-dependent generation of reactive oxygen species. J. Phys. Chem. B 112: 13608-13619.   DOI   ScienceOn
45 Choi, O. and Z. Hu. 2008. Size dependent and reactive oxygen species related nanosilver toxicity to nitrifying bacteria. Environ. Sci. Technol. 42: 4583-4588.   DOI   ScienceOn
46 Cha, K., H. W. Hong, Y. G. Choi, M. J. Lee, J. H. Park, H. K. Chae, G. Ryu, and H. Myung. 2008. Comparison of acute responses of mice livers to short-term exposure to nanosized or micro-sized silver particles. Biotechnol. Lett. 30: 1893-1899.   DOI   ScienceOn
47 Chaloupka, K., Y. Malam, and A. M. Seifalian. 2010. Nanosilver as a new generation of nanoproduct in biomedical applications. Trends in Biotechnology. 28: 580- 588.   DOI   ScienceOn
48 Chen, P. et al. 2007. Synthesis of silver nanoparticles by γ- ray irradiation in acetic water solution containing chitosan. Radiat. Phys. Chem. 76: 1165-1168.   DOI   ScienceOn
49 Cohen, M. L. 1992. Epidemiology of drug resistance; implications for a post-antimicrobial era. Science 257: 1050- 1055.   DOI
50 Courrol, L. C., F. R. O. Silva, and L. Gomes. 2007. A simple method to synthesize silver nanoparticles by photoreduction. Colloids Surf. A 305: 54-57.   DOI   ScienceOn
51 Butkus, M. A., M. P. Labare, J. A. Starke, K. Moon, and M. Talbot. 2004. Use of aqueous silver to enhance inactivation of coliphage MS-2 by UV disinfection. Appl. Environ. Microbiol. 70: 2848-2853.   DOI   ScienceOn
52 Yang, Q., F. Wang, K. Tang, C. Wang, Z. Chen, and Y. Qian. 2002. The formation of fractal Ag nanocrystallites via γ- irradiation route in isopropyl alcohol. Mater. Chem. Phys. 78: 495-500.
53 Vigneshwaran, N. et al. 2006. A novel one-pot 'green' synthesis of stable silver nanoparticles using soluble starch. Carbohydr. Res. 341: 2012-2018.   DOI   ScienceOn
54 Xu, G-N. et al. 2008. Preparation and characterization of stable monodisperse silver nanoparticles via photoreduction. Colloids Surf. A. 320: 222-226.   DOI
55 Yamanaka, M. et al. 2005. Bactericidal actions of a silver ion solution on Escherichia coli, studied by energy-filtering transmission electron microscopy and proteomic analysis. Appl. Environ. Microbiol. 71: 7589-7593.   DOI   ScienceOn
56 Arakawa, H., J. F. Neault, and H. A. Tajmir-Riahi. 2001. Silver(I) complexes with DNA and RNA studied by Fourier transform infrared spectroscopy and capillary electrophoresis. Biophys. J. 81: 1580-1587.   DOI   ScienceOn
57 Yang, W. J. et al. 2009. Food storage material silver nanoparticles interfere with DNA replication fidelity and bind with DNA. Nanotechnology. 20: 085102.   DOI   ScienceOn
58 Yeo, S. Y., H. J. Lee, and S. H. Jeong. 2003. Preparation of nanocomposite fibers for permanent antibacterial effect. J. Mater. Sci. 38: 2143-2147.   DOI   ScienceOn
59 Tien, D. C. et al. 2008. Colloidal silver fabrication using the spark discharge system and its antimicrobial effect on Staphylococcus aureus. Med. Eng. Phys. 30: 948-952.   DOI   ScienceOn
60 Alt, V., T. Bechert, P. Steinrucke, M. Wagener, P. Seidel, E. Dingeldein, D. Scheddin, E. Domann, and R. Schnettler. 2004. Nanoparticulate silver. A new antimicrobial substance for bone cement. Orthopade. 33: 885-892.