Solid Phase Synthesis of N-(3-hydroxysulfonyl)-L-homoserine Lactone Derivatives and their Inhibitory Effects on Quorum Sensing Regulation in Vibrio harveyi |
Kim, Cheol-Jin
(Department of Chemistry and Chemical Biology, Rutgers, The State University of New Jersey)
Park, Hyung-Yeon (Bio-Max Institute, Seoul National University) Kim, Jae-Eun (Environment Group, Samsung Advanced Institute of Technology, Samsung Electronics Co.) Park, Hee-Jin (School of Chemical and Biological Eng., Seoul National University) Lee, Bon-Su (Department of Chemistry, College of Natural Science, Inha University) Choi, Yu-Sang (Department of Pharmacy, College of Pharmacy, Pusan National University) Lee, Joon-Hee (Department of Pharmacy, College of Pharmacy, Pusan National University) Yoon, Je-Yong (School of Chemical and Biological Eng., Seoul National University) |
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10 | The NMR-data for the compound 6a: NMR (, 400MHz) =7.89 (s, 1H, NH), 4.79 (s, 1H, OH) 4.53 (ddd, J=5.96 hz,1H, CH-Lac), 4.46 (ddd, J=5.96 hz, 1H, CH-Lac), 3.88 (m, 2 H, ), 3.47-3.44 (m, 1 H, CH-Lac), 2.90 (d, J=6.96 hz, 2H, ), 2.70 (d, J=6.12hz, 2H, ), 2.52-2.49 (m, 1H, CH-Lac), 2.10-2.08 (m, 1H, CH-Lac), 2.0 (s, 1H, NH), 1.65 (m, 2H, ), 1.48-1.39 (m. 8H, ); HRMS (CI) calcd for ( + 1) 320.4100, found 320.4101 (Abbreviations: DIEA; diisopropyl ethylamine, HOBt, 1-hydroxybenzotriazole, BOP; benzotriazol-l-yl-oxy-tris(dimethylamino)phosphonium hexafluorophosphate, NMP; N-methyl-2-pyrrolidone, THF; tetrahydrofuran, and DMF; dimethylformamide) |
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