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Antibacterial Activity of HTI Isolated from Oriental Medicine, Hyungbangjihwang-tang  

Sung, Woo-Sang (Departmentn of Microbiology, College of Natural Sciences, Kyungpook National University)
Seu, Young-Bae (Departmentn of Microbiology, College of Natural Sciences, Kyungpook National University)
Lee, Dong-Gun (Departmentn of Microbiology, College of Natural Sciences, Kyungpook National University)
Publication Information
Microbiology and Biotechnology Letters / v.36, no.1, 2008 , pp. 82-85 More about this Journal
Abstract
Hyungbangjihwang-Tang (HT), an Oriental herbal formula, has been known to play a role which helps to recover vigor of human in the Orient. In this study, antibacterial substance (HTI) was purified from the ethyl-acetate extracts of HT by using $SiO_2$ column chromatography and HPLC, and the antibacterial effects of HTI were investigated. By using the CLSI broth micro-dilution assay, the activity of HTI was evaluated against human pathogenic Gram-positive and Gram-negative bacterial strains including the clinical isolates of methicillin-resistant Staphylococcus aureus. The results demonstrated that HTI showed broad spectrum antibacterial activities against all bacterial strains tested. In conclusion, HTI is an interesting new molecule for its potential in anti-infective drug discovery and for future studies on activity-structure relationship through analysis of its chemical structure.
Keywords
Hyungbangjihwang-Tang; antibacterial activity; oriental medicine; methicillin-resistant Staphylococcus aureus;
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