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Solid Medium pH-Dependent Antifungal Activity of Streptomyces sp. Producing an Immunosuppressant, Tautomycetin  

Hur, Yoon-Ah (Department of Biological Engineering, Inha University)
Choi, Si-Sun (Department of Biological Engineering, Inha University)
Chang, Yong-Keun (Department of Chemical and Biomolecular Engineering, Korea Advanced Institute of Science and Technology)
Hong, Soon-Kwang (Division of Bioscience and Bioinformatics, Myongji University)
Kim, Eung-Soo (Department of Biological Engineering, Inha University)
Publication Information
Microbiology and Biotechnology Letters / v.35, no.1, 2007 , pp. 26-29 More about this Journal
Abstract
Tautomycetin (TMC), which is produced by Streptomyces sp. CK4412, is a novel activated T cell-specific immunosuppressive compound with an ester bond linkage between a terminal cyclic anhydride moiety and a linear polyketide chain bearing an unusual terminal alkene. Antifungal activity against Aspergillus niger and TMC productivity assayed by HPLC using culture extracts from Streptomyces sp. CK4412 grown on solid medium adjusted at various pH were measured. The cells cultured at acidic pH (pH 4-5) medium exhibited much stronger antifungal activity as well as higher TMC productivity than those cultured at neutral pH medium, implying that the acidic pH-shock should be an efficient strategy to induce the productivity of secondary metabolites in Streptomyces culture.
Keywords
Streptomyces; tautomycetin; pH-dependent antifungal activity;
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