Isolation of a Fibrinolytic Bacterium from Cheongkukjang and Characterization of Its Bioactivity
![]() ![]() |
Lee, Dong-Geun
(Department of Pharmaceutical Engineering, Silla University)
Kim, Nam-Young (Department of Pharmaceutical Engineering, Silla University) Jang, Min-Kyung (Department of Pharmaceutical Engineering, Silla University) Yoo, Byung-Hong (Bioport Korea Corp.) Kim, Ki-Young (Bioport Korea Corp.) Kim, Sung-Goo (Bioport Korea Corp.) Jeong, Yong-Kee (Department of Biotechnology, Dong-A University) Lee, Sang-Hyeon (Department of Pharmaceutical Engineering, Silla University) |
1 | Chang J. H., Y. Y. Shim, S. H. Kim, K. M. Chee, and S. K. Cha. 2005. Fibrinolytic and immunostimulating activities of Bacillus spp. strains isolated from Chungkuk-jang. Kor. J. Food Sci. Technol. 37: 255-260 과학기술학회마을 |
2 | Lee, D. G., M. K. Jang, N. Y. Kim, J. H. Jeon, J. H. Lee, J. H. Lee, S. J. Kim, and S. H. Lee. 2006. Screening and characterization of a novel fibrinolytic metalloproteinase from a metagenomic library. Biotechnol. Lett. in press |
3 | Lee, J. O., S. D. Ha, A. J. Kim, C. S. Yuh, I. S. Bang, and S. H. Park. 2005. Industrial application and physiological functions of chonggkukhang. Food Sci. Indus. 38: 69-78 |
4 | Nathan, C. F. and J. B. Hibbs. 1991. Role of nitric oxide synthesis in macrophage antimicrobial activity. Curr. Opin. Immunol. 3: 65-70 DOI ScienceOn |
5 | Ryu, S. H. 2002. Studies on antioxidative effects and antioxidative components of soybean and chongkukjang. Doctorial thesis, Inje University of Korea, 23-122 |
6 | Wang, C. T., B. P. Ji, B. Li, R. Nout, P. L. Li, H. Ji, and L. F. Hong. 2006. Purification and characterization of a fibrinolytic enzyme of Bacillus subtilis DC33, isolated from Chinese traditional Douchi. J. Ind. Microbiol. Biotechnol. 33: 750-758 DOI |
7 | Woo, S. M. J. H. Kwon, and Y. J. Jeong. 2006. Selection and fermentation characteristics of Cheonggukjang strain. Kor. J. Food Preser. 13: 77-82 과학기술학회마을 |
8 | Amber, I. J., J. B. Hibbs, R. R. Taintor, Z. Vavrin. 1988. Cytokine induce an L-arginine-dependent effector system in nonmacrophage cells. J. Leuko. Biol. 44: 58-65 |
9 | Evans, T. G., L. Thai, D. L. Granger, and J. B. Jr. Hibbs. 1993. Effect of in vivo inhibition of nitric oxide production in murine Leishmaniasis. J. Immunol. 151: 907-915 |
10 | Kim, S. B., D. W. Lee, C. I. Cheigh, E. A. Choe, S. J. Lee, Y. H. Hong, H. J. Choi, and Y. R. Pyun. 2006. Purification and characterization of a fibrinolytic subtilisin-like protease of Bacillus subtilis TP-6 from an Indonesian fermented soybean, Tempeh. J. Ind. Microbiol. Biotechnol. 33: 436-444 DOI |
11 | Shon, M. Y., S. H. Kwon, S. K. Park, and J. S. Chor. 2001. Changes in chemical components of black bean Chungkukjang added with kiwi and radish during fermentation. Kor. J. Posthavest Sci. Technol. 8: 449-455 |
12 | Bartholomew, B. 1984. A rapid method for the assay of nitrate in urine using the nitrate reductase enzyme of Escherichia coli. Food Chem. Toxicol. 22: 541-549 DOI ScienceOn |
13 | Yoo, S. M. and C. M. Chang. 1999. Study on the processing adaptability of soybean cultivars for Korean traditional chonggugjang preparation. J. Kor. Soc. Agric. Chem. Biotechnol. 42: 91-98 |
14 | Fujita, M., K. Hong, Y. Ito, R. Fujii, K. Kariya, and S. Nishimuro. 1995. Thrombolytic effect of nattokinase on a chemically induced thrombosis model in rat. Biol. Pharm. Bull. 18: 1387-1391 |
15 | Kim, S. S., J. H. Lee, Y. S. Ahn, J. H. Kim, and D. K. Kang. 2003. A fibrinolytic enzyme from Bacillus amyloliquefaciens D4-7 isolated from chungkook-jang; It's characterization and influence of additives on thermostability. Kor. J. Microbiol. Biotechnol. 31: 271-276 |
16 | Green, S. J., M. S. Meltzer, J. B. Hibbs, and C. A. Nacy. 1990. Activated macrophages destroy intracellular Leishmania major amastigtes by an L-arginine-dependent killing mechanism. J. Immunol. 144: 278-283 |
17 | Lee, S. K., S. Heo, D. H. Bae, and K. H. Choi. 1998. Medium optimization for fibrinolytic enzyme production by Bacillus subtilis KCK-7 isolated from korean traditional chungkookjang. Kor. J. Appl. Microibol. Biotechnol. 26: 226-231 과학기술학회마을 |
18 | Anson, M. L. 1939. The estimation of pepsin, trypsin, papain and cathepsin with hemoglobin. J. Gen. Physiol. 22: 79-85 DOI |
19 | Hyun, K. W., J. S. Lee, J. H. Ham, and S. Y. Choi. 2005. Isolation and identification of microorganism with potent fibrinolytic activity from Korean traditional Deonjang. Kor. J. Microbiol. Biotechnol. 33: 24-28 과학기술학회마을 |
20 | Nakajima, N., H. Mihara, and H. Sumi. 1993. Characterization of potent fibrinolytic enzymes in earthworm, Lumbricus rubellus. Biosci. Biotechnol. Biochem. 57: 1726-1730 |
21 | Astrup, T. and S. Mullertz. 1952. The fibrin method for estimating of fibrinolytic activity. Arch. Biochem. Biophys. 40: 346-351 DOI ScienceOn |
22 | Kolb, H. and V. Kolb-Bachofen. 1992. Nitric oxide: A pathogenetic factor in autoimmunity. Immunol. Today 13: 157-160 DOI ScienceOn |
23 | Snyder, S. H., D. S. Bredt. 1992. Biological roles of nitric oxide. Scientific Am. May: 68-77 |
24 | Kim, S. C., S. H. Lee, and S. J. Wi. 2002. The effects of natto mucilage on the components of serum lipid in rats. J. Kor. Oil Chemists' Soc. 19: 63-67 |
25 | Hibbs, J. B. Jr., Z. Vavrin, R. R. Taintor, and E. M. Rachlin. 1988. Nitric oxide: A cytotoxic activated macrophage effector molecule. Biochem. Biophys. Res. Commun. 157: 87-94 DOI ScienceOn |
26 | Lee, B. Y., D. M. Kim, and K. H. Kim. 1991. Physicochemical properties of viscous substance extracted from chungkookjang. Kor. J. Food Sci. Technol. 23: 599-604 |
27 | Kwon, H. Y., Y. S. Kim, G. S. Kwon, C. S. Kwon, and H. Y. Sohn. 2004. Isolation of immunostimulating strain Bacillus pumilus JB-1 from chungkookjang and fermentaional characteristics of JB-1. Kor. J. Microbiol. Biotechnol. 32: 291-296 |
28 | Sumi, H., H. Hamada, K. Nakanishi, and H. Hiratani. 1990. Enhancement of the fibrinolytic activity in plasma by oral administration of nattokinase. Acta Haematol. 84: 139-143 DOI |
29 | Yun, G. H., E. T. Lee, and S. D. Kim. 2003. Purification and characterization of a fibrinolytic enzyme produced from Bacillus amyloliquefaciens K42 isolated from Korean soy sauce. Kor. J. Microbiol. Biotechnol. 31: 284-291 과학기술학회마을 |
![]() |