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Screening of Anti-acne Activity of Natural Products against Propionibacterium acnes  

Sohn Ho-Yong (Department of Food and Nutrition, Andong National University)
Kim Young-Suk (Department of Food and Nutrition, Andong National University)
Kum Eun-Joo (Department of Food and Nutrition, Andong National University)
Kwon Yun-Sook (Department of Food and Nutrition, Andong National University)
Son Kun-Ho (Department of Food and Nutrition, Andong National University)
Publication Information
Microbiology and Biotechnology Letters / v.34, no.3, 2006 , pp. 265-272 More about this Journal
Abstract
Acne is a chronic inflammatory follicular disorder of the skin, occurring in specialized pilosebaceous units on the face, and Propionibacterium acnes, a strict anaerobic pathogen, plays an important role in the pathogenesis of acne. To develop a reliable and effective anti-acne agent, we have evaluated antibacterial activity of 500 plant extracts, prepared from 335 plants, against P. acnes. Based on the results of disc-paper method, 25 plant extracts, including the extracts of Chloranthus japonicus (aerial part), Sophora flavescens (radix), Evodia officinalis (fructus), Ginko biloba (semem), Morus alba (root bark), Aralia continentalis (whole) and Reynoutria elliptica (radix), were selected as possible sources of anti-acne agent. Among them, the extract of S. flavescens (radix) was finally selected and kuraridin and kurarinone were identified as major active compounds of S. flavescens. These results suggested that medicinal and wild plants could be the potential source of anti-acne agent.
Keywords
Anti-acne activity; medicinal and wild plants; Propionibacterium acnes; Sophora flavescens;
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Times Cited By SCOPUS : 4
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