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Production of an Antihyperlipemial HMG-CoA Reductase Inhibitor from Bacillus cereus D-3  

Lee Dae-Hyoung (Department of Life Science and Genetic Engineering, Paichai University)
Lee Jae-Won (Department of Life Science and Genetic Engineering, Paichai University)
Jeong Jae-Hong (Agriculture Venture Team. Chungnam Agriculture Techno-Park)
Lee Jong-Soo (Department of Life Science and Genetic Engineering, Paichai University)
Publication Information
Microbiology and Biotechnology Letters / v.34, no.1, 2006 , pp. 52-57 More about this Journal
Abstract
For the purpose of production of a novel antihyperlipemial HMG-CoA reductase inhibitor from bacteria, a bacterium which showed the highest HMG-CoA reductase inhibitory activity was isolated from traditional Doenjang. This strain was identified as Bacillus cereus (D-3) based on its microbiological characteristics and 165 rRNA sequence analysis. The maximal HMG-CoA reductase inhibitor production from Bacillus cereus D-3 was obtained by cultivation in a Glucose-CSL broth containing 2% glucose, 0.6% corn steep liquor, $0.04%\;K_{2}HPO_4$ and $0.05%\;KH_{2}PO_4$ at $30^{\circ}C$ for 36 h. The final HMG-CoA reductase inhibitory activity under the above conditions was 39.4%.
Keywords
Antihyperlipemial substance; HMG-CoA reductase inhibitor; Bacillus cereus D-3;
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