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Protective Effects of $\beta$-Immunan Isolated from the Mycelium of Ganoderma lucidum IY009 against Cisplatin-induced Nephrotoxicity  

김용석 (일양약품 중앙연구소)
배우철 (일양약품 중앙연구소)
박정민 (일양약품 중앙연구소)
이준우 (경북전문대학 식품가공과)
백성진 (바이오톡스텍)
이상봉 (바이오톡스텍)
윤경하 (순천향대학교 생물학과)
Publication Information
Microbiology and Biotechnology Letters / v.32, no.3, 2004 , pp. 271-276 More about this Journal
Abstract
$\beta$-Immunan was proteoglycan obtained from mycelium of Ganoderma lucidum IY009. In this study, the protective effects of $\beta$-Immunan, against the CDDP induced in vitro cytotoxicity and in vivo renal toxicity, was measured. Concentration dependent cytotoxicities of CDDP in normal kidney cells (Vero, TCMK-l) were reduced by $\beta$-Immunan treatment. Increased renal toxicity factors, such as elevation of blood urea nitrogen (BUN) and serum creatinine, reduction of kidney weight and malonidialdehyde (MDA), by intraperitoneal administration of CDDP in rats was improved. These results indicated that $\beta$-Immunan have a protective effects against the CDDP induced renal toxicity, however, it needed to confirm the detailed mechanism for therapeutic effects.
Keywords
$\beta$-Immunan; Ganoderma lucidum IY009; cisplatin; protective effects; renal toxicity;
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